NCT01504971

Narrow-band Imaging, Autofluorescence Imaging and Gastroesophageal Reflux Disease

Diagnostic Value of Narrow-band Imaging, Autofluorescence Imaging & White-light Imaging on Gastroesophageal Reflux Disease

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 95 (actual)
• Sponsor: Chinese PLA General Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Accepted

Summary

Aim of this study is to compare the efficacy of narrow band imaging (NBI) and autofluorescence imaging (AFI) to distinguish subtle mucosal change related to acid reflux that is not visible in standard white light imaging (WLI) endoscopy, and help indicating the diagnosis of gastroesophageal reflux disease (GERD).

Detailed description

GERD is a common condition that develops when the reflux of gastric and/or duodenal contents causes troublesome symptoms with or without mucosal damage or complications. Despite the high prevalence of GERD in the general population, up to 60% of patients with reflux symptoms is insufficiently characterized as having normal endoscopic finding based on standard WLI endoscopy: non-erosive reflux diseases (NERD). NBI is an optical-digital imaging technology that uses two specific narrow-banded shot wavelength lights (400-430 nm and 525-555 nm) instead of broad band white light. The NBI contrasts surface structure and vascular architecture of the superficial mucosa and facilitates evaluation of indistinct mucosal morphology. AFI produces real-time computed images of endoscopically detected autofluorescence emitted from endogenous fluorophores in the digestive tract (collagen, nicotinamide, adenine dinucleotide, flavin, and porphyrins) caused by light excitation. The AFI can identify lesions due to differences in tissue fluorescence properties that are not detectable by standard WLI. Hence, our hypothesis is that new endoscopic imaging i.e. NBI and AFI would help to identify subtle mucosal change which indicates the diagnosis of GERD

Conditions

• Gastroesophageal Reflux Disease

Interventions

Type	Name	Description
OTHER	symptom questionaire	GerdQ questionaire
PROCEDURE	pH monitoring	24-hour pH monitoring
PROCEDURE	Tri-modal imaging endoscopy	To investigate WLI,NBI and AFI
DRUG	rabeprazole	10mg, bid, p.o.

Timeline

• Start date: 2011-01-01
• Primary completion: 2012-06-01
• Completion: 2016-12-01
• First posted: 2012-01-06
• Last updated: 2015-09-02
• Results posted: 2015-09-02

Locations

1 site across 1 country: China