NCT01065649

Effect of Nortriptyline in Cortical Representation of Heartburn in Nonerosive Reflux Disease (NERD) Patients

Effect of Nortriptyline in the Cortical Representation of Heartburn in Patients With Nonerosive Reflux Disease

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Universidade de Passo Fundo · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Patients with nonerosive reflux disease (NERD) are less responsive to standard treatment with proton pump inhibitors. The hypothesis of this study was that nortriptyline in analgesic doses may decrease heartburn perception and its corresponding cortical activity measured by magnetic resonance image. Therefore, the aim of this study was to assess the cortical representation of heartburn in patients with NERD under treatment with nortriptyline and placebo.

Conditions

• Gastroesophageal Reflux Disease

Interventions

Type	Name	Description
DRUG	Nortriptyline	It will be administered per oral 10 mg a day in the first 7 days and then 25 mg a day in the last 14 days
DRUG	Placebo arm	Placebo per oral for 21 days, equal to nortriptyline

Timeline

• Start date: 2010-01-01
• Primary completion: 2010-06-01
• Completion: 2010-06-01
• First posted: 2010-02-09
• Last updated: 2012-07-17

Locations

1 site across 1 country: Brazil