NCT06277921

Morbidity and Mortality After Esophageal and Esophagogastric Junction Cancer Surgery

90-day Postoperative Morbidity and Mortality After Elective Surgery for Esophageal and Esophagogastric Junction Cancer

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 230 (actual)
• Sponsor: P. Herzen Moscow Oncology Research Institute · Other Government
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Esophageal and esophagogastric junction cancer is still one of the main health care issue and esophagectomy with lymph node dissection is the only chance to be cure. However, esophagectomy for esophageal cancer is a complex procedure which carries high risk of morbidity rate of 24% and a mortality rate of 2% to 5.6%, respectively There is a need to study the differences of 90-day postoperative morbidity and mortality in different clinics and centers of the Russian Federation.

Detailed description

Esophageal and esophago-gastric junction cancer is the seventh most common malignancy and the sixth leading cause of cancer-related mortality worldwide. Surgery remains the primary treatment for esophageal cancer and is one of the most technically challenging interventions in oncological surgery. In addition, esophagectomy is associated with high risks of postoperative complications, with rates varying from clinic to clinic. Esophagectomy for esophageal cancer is a complex procedure which carries high risk of morbidity rate of 24% and a mortality rate of 2% to 5.6%, respectively. The problem with the available studies of the course of the postoperative period is the significant heterogeneity of research methods, which does not allow us to obtain a true picture of the results of surgical treatment of the esophagus and esophagogastric junction cancer in the Russian Federation. To improve the quality of further studies and recommendations on standardization of surgical treatment of esophageal and esophagogastric junction cancer and its morbidity, there is a need to study the differences of 90-day postoperative morbidity and mortality in different clinics and centers of the Russian Federation.

Conditions

• Esophageal Cancer
• Oesophageal Cancer
• Siewert Type I Adenocarcinoma of Esophagogastric Junction
• Siewert Type III Adenocarcinoma of Esophagogastric Junction

Interventions

Type	Name	Description
PROCEDURE	Elective Surgery for gastric cancer	Resection of the esophagus and the gastroesophageal junction via open, laparoscopic or robotic approach

Timeline

• Start date: 2024-03-18
• Primary completion: 2024-09-18
• Completion: 2025-01-20
• First posted: 2024-02-26
• Last updated: 2025-07-02

Locations

18 sites across 2 countries: Belarus, Russia