NCT07307560

High-Flow Nasal Cannula for Preventing Hypoxia During Sedated Endoscopy in High-Risk Obstructive Sleep Apnea Patients

High-Flow Nasal Cannula for Preventing Hypoxia During Sedated Endoscopy in High-Risk Obstructive Sleep Apnea Patients: A Multicenter Randomized Trial

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 600 (estimated)
• Sponsor: Zhejiang University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Hypoxia represents the most frequent adverse event during propofol-sedated gastrointestinal endoscopy. The STOP-BANG questionnaire serves as a widely adopted, straightforward tool for screening obstructive sleep apnea (OSA) risk, with a score ≥5 identifying high-risk OSA patients who are particularly susceptible to hypoxia under sedation. Although preliminary research from our team suggests that High-Flow Nasal Cannula (HFNC) may lower the incidence of hypoxemia, evidence remains limited and inconsistent in studies specifically targeting high-risk OSA populations. Therefore, this multicenter randomized controlled trial aims to evaluate whether HFNC can effectively reduce the occurrence of hypoxia during sedated gastrointestinal endoscopy in patients identified as high-risk for OSA.

Conditions

• Hypoxia
• Esophageal Cancer
• Gastric Cancer (Diagnosis)
• Obstructive Sleep Apnea (OSA)

Interventions

Type	Name	Description
DEVICE	High-flow nasal cannula Group	Using High-flow nasal cannula oxygenation
DEVICE	Regular Nasal Cannula	Using regular nasal cannula for oxygenation

Timeline

• Start date: 2025-12-21
• Primary completion: 2026-12-01
• Completion: 2026-12-01
• First posted: 2025-12-29
• Last updated: 2026-02-27

Locations

3 sites across 1 country: China