NCT06712706

Effect of Feeding Jejunostomy on Sarcopenia in Patients with Esophageal Cancer

Effect of Feeding Jejunostomy Placement on Sarcopenia in Patients with Advanced Stages of Esophageal Cancer in Curate Cancer Treatment

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 70 (estimated)
• Sponsor: Stefan Gutknecht · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Participants were diagnosed with esophageal cancer needing chemo- or radiochemotherapy before the potentially curing surgery consisting of esophagectomy. At the time of diagnosis, in all participants, a laparoscopy to complete staging was performed. In some patients, a feeding jejunostomy tube (FJT) was placed at the time of staging laparoscopy; in others, the FJT was placed at the time of esophagectomy. A common risk factor for higher morbidity and mortality is sarcopenia, a condition associated with low skeletal muscle. This study aims to determine whether the timing of the FJT placement affects the progress of sarcopenia.

Detailed description

At the City Hospital Zurich Triemli, an FJT tube is inserted in approximately two-thirds of patients before commencing neoadjuvant therapy. Another third receive an FJT at the time of esophagectomy to ensure postoperative enteral feeding. To this day, no prospective, randomized study exists as to whether placing an FJT at diagnosis or esophagectomy impacts sarcopenia. Retrospectively collected data is limited due to small sample sizes and observational character. This is a retrospective, single-center cohort study using disease-related data already collected. The study design includes statistical balancing techniques to achieve comparability between the two groups and estimate an unbiased treatment effect of the timing of FJT placement. All data is extracted from the clinical information systems and radiological systems and is credible, protected data. It is taken exclusively from the medical records; patients are not contacted for data collection.

Conditions

• Esophageal Cancer
• Esophageal Carcinoma
• Sarcopenia
• Feeding Tube

Interventions

Type	Name	Description
PROCEDURE	Feeding jejunostomy placement	Placement of feeding jejunostomy at staging laparoscopy
PROCEDURE	Feeding jejunostomy placement at esophagectomy	Placement of feeding jejunostomy at esophagectomy

Timeline

• Start date: 2024-11-30
• Primary completion: 2024-12-31
• Completion: 2025-01-31
• First posted: 2024-12-02
• Last updated: 2024-12-04

Locations

1 site across 1 country: Switzerland