| Enrolling By Invitation | Adaptive Neoadjuvant Therapy for Esophageal Cancer NCT06990178 | Cancer Hospital Chinese Academy of Medical Science, Shenzhen Center | N/A |
| Recruiting | Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays NCT07283939 | Alliance for Clinical Trials in Oncology | N/A |
| Not Yet Recruiting | Timing of Minimally Invasive Local Treatment After First-Line Systemic Therapy in Oligometastatic Esophageal o NCT07000253 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Phase 2 / Phase 3 |
| Recruiting | Detection of Upper Gastrointestinal Tumour Depth and Demarcation Using Systemic Administration of Indocyanine NCT07108855 | University Medical Center Groningen | Phase 1 / Phase 2 |
| Recruiting | Determining the Biodistribution of an Imaging Tracer (68Ga-FAPi-46) in Patients With Solid Tumors or Hematolog NCT07118176 | Jonsson Comprehensive Cancer Center | Phase 1 |
| Not Yet Recruiting | Definitive Proton Radiotherapy Combined With Chemotherapy and Immunotherapy for Locally Advanced Esophageal Sq NCT07034118 | Anhui Provincial Hospital | Phase 1 |
| Recruiting | Impact of Prehabilitation in Oncology Via Exercise- Esophageal (IMPROVE-Esophageal) NCT06872515 | University of Pittsburgh | N/A |
| Recruiting | The Vanguard Study: Testing a New Way to Screen for Cancer NCT06995898 | National Cancer Institute (NCI) | N/A |
| Recruiting | CCRT Followed by PD-1 Inhibitor Maintenance Therapy in Locally Advanced ESCC NCT06964568 | Fudan University | Phase 3 |
| Recruiting | PET-imaging of Two Vartumabs in Patients With Solid Tumors NCT06645808 | Var2 Pharmaceuticals | EARLY_Phase 1 |
| Not Yet Recruiting | Effect of Feeding Jejunostomy on Sarcopenia in Patients with Esophageal Cancer NCT06712706 | Stefan Gutknecht | — |
| Recruiting | TDLN-sparing RT Plus Immunotherapy and Chemotherapy in Locally Advanced ESCC NCT06676449 | Fudan University | Phase 3 |
| Not Yet Recruiting | Cadonilimab Combined With Anlotinib Followed by Radiotherapy in Recurrent or Metastatic Esophageal Squamous Ce NCT06681285 | Hebei Medical University Fourth Hospital | Phase 2 |
| Withdrawn | Defining Musical Toxicity and Its Effect on Patient Well-being NCT06494046 | Mayo Clinic | — |
| Recruiting | Amiodarone for the Prevention of Atrial Fibrillation After Minimally Invasive Esophagectomy in Patients With E NCT06067438 | OHSU Knight Cancer Institute | Phase 2 |
| Recruiting | Comparison of In-Home Versus In-Clinic Administration of Subcutaneous Nivolumab Through Cancer CARE (Connected NCT06265285 | Mayo Clinic | Phase 2 |
| Unknown | Thalidomide Prevention or Treatment of Camrelizumab-induced Reactive Cutaneous Capillary Endothelial Prolifera NCT06231680 | Henan Cancer Hospital | Phase 2 |
| Recruiting | Serplulimab Combined With Concurrent Chemoradiotherapy for Locally Advanced Treatment Esophageal Cancer in Old NCT06354218 | The First Affiliated Hospital with Nanjing Medical University | Phase 2 |
| Recruiting | Clinical Efficacy and Safety of Paclitaxel Polymeric Micelles for Injection in the Treatment of Patients With NCT06199895 | Liu Huang | Phase 2 |
| Not Yet Recruiting | Neoadjuvant Therapy of Anlotinib Combined With Toripalimab and Chemotherapy for Resectable Esophageal Carcinom NCT05996484 | Nanfang Hospital, Southern Medical University | Phase 2 |
| Recruiting | Postoperative Radiotherapy Followed by Immunotherapy for Locally Advanced Esophageal Carcinoma NCT05937438 | Anhui Provincial Hospital | Phase 1 / Phase 2 |
| Recruiting | 18F-FSPG PET/CT as a Non-Invasive Imaging Biomarker for Treatment Response to Chemoradiation in Esophageal Can NCT06549413 | M.D. Anderson Cancer Center | — |
| Terminated | A Study to Evaluate Nivolumab in the Treatment of Early Stage Esophageal or Gastroesophageal Cancer NCT05780736 | Bristol-Myers Squibb | — |
| Completed | A Safety and Efficacy Study Evaluating CTX131 in Adult Subjects With Relapsed or Refractory Solid Tumors NCT05795595 | CRISPR Therapeutics AG | Phase 1 / Phase 2 |
| Recruiting | Minimally Residual of Esophageal Cancer 001 NCT05952661 | Hebei Medical University Fourth Hospital | — |
| Recruiting | PET/CT Imaging to Evaluate Cardiac Radiation Damage in Patients With Lung or Esophageal Cancer, EUCLID Trial NCT05775939 | Thomas Jefferson University | N/A |
| Recruiting | Toripalimab Combined With Radiotherapy and S-1 for Older Patients With Esophageal Cancer NCT06009705 | Hebei Medical University Fourth Hospital | — |
| Recruiting | ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation NCT05059444 | Guardant Health, Inc. | — |
| Completed | Oral Cryotherapy Plus Acupressure and Acupuncture Versus Oral Cryotherapy for Decreasing Chemotherapy-Induced NCT04505553 | University of Washington | Phase 2 |
| Unknown | Neoadjuvant Therapy of Camrelizumab Combined With Chemotherapy for Resectable Locally Advanced Esophageal Squa NCT05476380 | Tianjin Medical University Cancer Institute and Hospital | Phase 2 |
| Completed | Perioperative Outcomes and Survival of Inflatable Video-Assisted Mediastinoscopic Transhiatal Esophagectomy fo NCT07182266 | Shanghai Zhongshan Hospital | — |
| Completed | Impact of Arterial Partial Pressure of Oxygen on Anastomotic Leakage After Esophagectomy NCT07309991 | Sun Yat-sen University | — |
| Completed | Nimotuzumab Combined With Concurrent Chemoradiotherapy for Locally Advanced Treatment Esophageal Cancer in Old NCT06048913 | The First Affiliated Hospital with Nanjing Medical University | Phase 2 |
| Active Not Recruiting | National Cancer Institute "Cancer Moonshot Biobank" NCT04314401 | National Cancer Institute (NCI) | — |
| Recruiting | Robot-assisted Thoracic Approach Versus Open Transthoracic Esophagectomy . NCT04652180 | Hospital Universitari de Bellvitge | N/A |
| Unknown | Neoadjuvant Therapy of PD-1 Blockade Combined With Chemotherapy for Esophageal Carcinoma NCT05777707 | Beijing Friendship Hospital | Phase 1 / Phase 2 |
| Unknown | Randomised Trial Evaluating the Benefit of a Fitness Tracker Based Workout During Radiotherapy NCT04517019 | University Hospital Tuebingen | N/A |
| Completed | Inter-Observer Delineation Differences in Esophageal Cancer GTV on MR, CT, and PET/CT Protokol šečerov Ermenc NCT07416825 | Institute of Oncology Ljubljana | N/A |
| Active Not Recruiting | Experimental PET Imaging Scans Before Cancer Surgery to Study the Amount of PET Tracer Accumulated in Normal a NCT04147494 | Jonsson Comprehensive Cancer Center | EARLY_Phase 1 |
| Active Not Recruiting | Yoga Program for Improving the Quality of Life in Couples Coping With Cancer NCT04607590 | M.D. Anderson Cancer Center | N/A |
| Recruiting | Dyadic Yoga Intervention in Improving Physical Performance and Quality of Life in Patients With Stage I-IV Non NCT03948100 | M.D. Anderson Cancer Center | N/A |
| Completed | Different Radiation Dose of Neoadjuvant Chemoradiation for Resectable Thoracic Esophageal Squamous Carcinoma NCT03381651 | Zhejiang Cancer Hospital | N/A |
| Withdrawn | Nivolumab or Expectant Observation Following Ipilimumab, Nivolumab, and Surgery in Treating Patients With High NCT03220009 | National Cancer Institute (NCI) | Phase 2 |
| Unknown | Robot-assisted Esophagectomy Versus Conventional Thoracoscopic Esophagectomy NCT03094351 | Shanghai Chest Hospital | Phase 3 |
| Active Not Recruiting | Induction Chemotherapy for Locally Advanced Esophageal Cancer NCT03110926 | University of Rochester | Phase 2 |
| Unknown | Phase 1 Dose Escalation Study of CGX1321 in Subjects With Advanced Gastrointestinal Tumors NCT03507998 | Curegenix Inc. | Phase 1 |
| Completed | Study of SHR-1210 Versus Investigator's Choice of Chemotherapy for Participants With Advanced Esophageal Cance NCT03099382 | Jiangsu HengRui Medicine Co., Ltd. | Phase 3 |
| Unknown | A Clinical Research of CAR T Cells Targeting EpCAM Positive Cancer NCT03013712 | First Affiliated Hospital of Chengdu Medical College | Phase 1 / Phase 2 |
| Completed | Botulinum Toxin Type A in Preventing Complications After Surgery in Patients With Esophageal Cancer NCT02965976 | Roswell Park Cancer Institute | Phase 2 |
| Completed | Study of Pembrolizumab (MK-3475) Versus Investigator's Choice of Chemotherapy for Participants With Advanced E NCT03933449 | Merck Sharp & Dohme LLC | Phase 3 |
| Completed | Study of Pembrolizumab (MK-3475) in Previously-Treated Participants With Advanced Carcinoma of the Esophagus o NCT02559687 | Merck Sharp & Dohme LLC | Phase 2 |
| Completed | Study of Pembrolizumab (MK-3475) Versus Investigator's Choice Standard Therapy for Participants With Advanced NCT02564263 | Merck Sharp & Dohme LLC | Phase 3 |
| Active Not Recruiting | Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymph NCT02465060 | National Cancer Institute (NCI) | Phase 2 |
| Active Not Recruiting | The Neoadjuvant Treatment Modalities in Patients With Locally Advanced Esophageal Squamous Cell Carcinoma (NEO NCT06828718 | Hebei Medical University Fourth Hospital | — |
| Unknown | Diffusion-weighted Magnetic Resonance Imaging (DW-MRI )for Early Response Assessment in Patients With Esophage NCT02527057 | Hunan Province Tumor Hospital | — |
| Unknown | Traditional Three Incisions vs Minimally Invasive Thoracol-laparoscopic Esophagectomy for Esophageal Cancer NCT02355249 | Chinese Academy of Medical Sciences | Phase 3 |
| Terminated | Doxepin Hydrochloride in Treating Esophageal Pain in Patients With Thoracic Cancer Receiving Radiation Therapy NCT02062632 | Mayo Clinic | Phase 2 |
| Completed | Feasibility Study of Chemoradiation, TRAstuzumab and Pertuzumab in Resectable HER2+ Esophageal Carcinoma NCT02120911 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Phase 1 / Phase 2 |
| Unknown | Comparable Study of Different Radiation Dose in Esophageal Carcinoma NCT01937208 | Zhejiang Cancer Hospital | Phase 3 |
| Completed | Second-line Treatment With Icotinib in Esophageal Carcinoma Patients With EGFR Overexpression (IHC 3+) or Posi NCT01855854 | Betta Pharmaceuticals Co., Ltd. | Phase 2 |
| Completed | Concurrent Chemoradiation With or Without DC-CIK Immunotherapy in Treating Locally Advanced Esophageal Cancer NCT01691625 | Capital Medical University | N/A |
| Completed | Robot-assisted Thoraco-laparoscopic Esophagectomy Versus Open Transthoracic Esophagectomy NCT01544790 | UMC Utrecht | Phase 3 |
| Active Not Recruiting | Veliparib, Paclitaxel, and Carboplatin in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be NCT01366144 | National Cancer Institute (NCI) | Phase 1 |
| Completed | Narrow Band Imaging (NBI): A Novel Imaging Modality in Minimally Invasive NCT01262040 | Memorial Sloan Kettering Cancer Center | N/A |
| Completed | Ursodiol in Treating Patients With Barrett Esophagus and Low-Grade Dysplasia NCT01097304 | National Cancer Institute (NCI) | Phase 2 |
| Completed | Liposomal Paclitaxel Combined Nedaplatin in Treatment of Advanced or Recurrent Esophageal Carcinoma NCT02861690 | Sun Yat-sen University | Phase 2 |
| Unknown | Study of Lobaplatin，5-Fluorouracil and Leucovorin for the Treatment of Esophageal Carcinoma NCT01034683 | Taian Cancer Hospital | Phase 3 |
| Withdrawn | Study of Cetuximab and Bevacizumab in Cancer of the Esophagus After Failure of Patient's First Therapy NCT00636298 | Emory University | Phase 2 |
| Unknown | A Clinical Trial of a Radiation Sensitizer in Radiochemotherapy for Thoracic Esophageal Squamous Carcinoma NCT00642239 | Shandong Luye Pharmaceutical Co., Ltd. | Phase 4 |
| Completed | Staging and Outcome Depending on Surgical Treatment in Adenocarcinomas of the Oesophagogastric Junction NCT01766986 | Universitätsklinikum Hamburg-Eppendorf | — |
| Completed | Safety and Immune Response to a Multi-component Immune Based Therapy (MKC1106-PP) for Patients With Advanced C NCT00423254 | Mannkind Corporation | Phase 1 |
| Completed | A Study to Evaluate the Combination of Cetuximab and Chemotherapy as Neoadjuvant Therapy Followed Concomitant NCT00733889 | Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD) | Phase 2 |
| Recruiting | Data Collection for the Assessment of Acute and Late Normal Tissue in Patients Treated With Proton Therapy NCT00991094 | M.D. Anderson Cancer Center | — |
| Completed | Phase II Trial of Preoperative Combined Modality Therapy for Esophageal Carcinoma: Cisplatin-Irinotecan Follow NCT00590031 | Memorial Sloan Kettering Cancer Center | Phase 2 |
| Completed | Chemoradiation and Tetrathiomolybdate (TM) in Patients With Esophageal Carcinoma NCT00176800 | University of Michigan Rogel Cancer Center | Phase 2 |