Clinical Trials Directory

Trials / Sponsors / Hebei Medical University Fourth Hospital

Hebei Medical University Fourth Hospital

Academic / Other · 69 registered clinical trials43 currently recruiting.

StatusTrialPhaseStarted
Not Yet RecruitingOlaparib in the Treatment of BRCA1/2 Unmutated and BRCA1 Promoter Methylated Recurrent and Metastatic Triple-n
Solid Tumor
Phase 22026-09-01
Not Yet RecruitingNeoadjuvant SHR-A1811 Combined With Pertuzumab in HER2-Positive Breast Cancer: An Exploratory Clinical Study.
Breast Cancer
Phase 22026-05-01
Not Yet RecruitingShort-course Radiotherapy in TNT Combined With Enlonstobart for pMMR LARC
Efficacy and Safety of Short-course Radiotherapy in Total Neoadjuvant Therapy Combined With Enlonstobart for pMMR Locally Advanced Rectal Cancer
Phase 22026-03-01
Not Yet RecruitingctDNA Monitoring Guides the Treatment of NSCLC With Befotertinib Combined With Radiotherapy
Patients With Advanced Oligometastatic Non-small Cell Lung Cancer (NSCLC) Who Have Tested Positive for EGFR Mutations Confirmed by Histopathological Examination
Phase 22026-02-10
Not Yet RecruitingRadiotherapy Combined With QL1706 and Bevacizumab for Unresectable Non-metastatic Hepatocellular Carcinoma
Hepatocellular Carcinoma
Phase 22025-12-01
RecruitingIparomlimab and Tuvonralimab Combined With Apatinib and Irinotecan Hydrochloride for the Treatment of Advanced
AFP Gastric or Gastroesophageal Junction Adenocarcinoma, PD-1/CTLA-4, AFPGC
Phase 22025-09-28
RecruitingThe Efficacy and Safety of Iparomlimab and Tuvonralimab Injection Combined With Chemotherapy as the First-line
Esophageal Squamous Cell Carcinoma (ESCC)
Phase 22025-09-26
RecruitingConstruction and Evaluation of Tumor Immunotherapy and Organ Damage Early Warning System Based on Multi-omics
Malignant Neoplasm, Organ Damage
2025-09-15
RecruitingDalpiciclib With or Without Entinostat and Letrozole in HR+/HER2- Early Breast Cancer
Breast Cancer
Phase 22025-09-12
Not Yet RecruitingThis Study Aims to Optimize Neoadjuvant Therapy for HER2-positive Breast Cancer by Implementing a Dynamic Moni
HER2-positive Breast Cancer
Phase 22025-09-01
RecruitingClinical Study of Adbelimumab in the Adjuvant Treatment of Esophageal Squamous Cell Carcinoma.
Squamous Oesophageal Cancer
Phase 22025-09-01
Not Yet RecruitingA Phase II Clinical Study of Induction Adebrelimab Combined With Chemotherapy Followed by Concurrent Chemoradi
Locally Advanced Unresectable Esophageal Squamous Cell Carcinoma
Phase 22025-08-10
Not Yet RecruitingEfficacy and Safety of Iparomlimab and Tuvonralimab Injection in Combination With Bevacizumab After Progressio
PD-(L)1, CTLA-4, Advanced Melanoma
Phase 42025-07-01
RecruitingInvolved-field Radiotherapy-TNT Combined With PD-1 Inhibitor for pMMR Locally Advanced Rectal Cancer (Neo-Fiel
Locally Advanced Rectal Cancer
Phase 22025-07-01
Not Yet RecruitingNeratinib in Extended Adjuvant Treatment for HER2+ Early Breast Cancer With pCR But High-Risk Features: A Hebe
HER2-positive Breast Cancer
2025-06-30
RecruitingReal-world Study on the Prevention of Neutropenia After Tumor Treatment With Mecapegfilgrastim Injection
Neutropenia
2025-06-18
RecruitingTumor Local Excision +Postoperative Adjuvant Chemoradiotherapy for T1-2N0M0 Low/Ultra-Low Rectal Cancer
Rectal Cancer Stage I
Phase 22025-05-15
RecruitingRadiotherapy + Systemic Therapy as Conversion Therapy for pMMR/MSS T4M0 Colon Cancer(Neo-Color)
Colon Cancer
Phase 22025-05-15
Not Yet RecruitingToripalimab Adjuvant Therapy in Subjects With Resected Esophageal Squamous Cell Carcinoma Who Achieved Patholo
Esophageal Squamous Cell Carcinoma Stage II, Esophageal Squamous Cell Carcinoma Stage III
Phase 22025-04-01
Not Yet RecruitingTislelizumab in Combination with Chemotherapy ± Radiotherapy for Extensive-Stage Oligometastatic Small Cell Lu
Small Cell Lung Cancer Extensive Stage
Phase 22025-03-01
Not Yet RecruitingCadonilimab Combined With Anlotinib Followed by Radiotherapy in Recurrent or Metastatic Esophageal Squamous Ce
Esophageal Carcinoma
Phase 22024-11-01
RecruitingEfficacy and Safety of Dalpiciclib in Hormone Receptor-positive Advanced Breast Cancer
Breast Cancer
2024-09-13
RecruitingHypofractionated Radiotherapy +Chemotherapy+ Camrelizumab as Neoadjuvant Therapy for Pancreatic Cancer
Pancreatic Cancer
Phase 22024-08-01
Not Yet RecruitingLiposomal Irinotecan With Cisplatin and Concurrent Radiotherapy in Locally Advanced Esophageal Squamous Cell C
Esophageal Squamous Cell Carcinoma
Phase 12024-06-27
WithdrawnAdebrelimab Combined With Chemoradiotherapy for Locally Advanced Unresectable Esophageal Squamous Cell Carcino
Esophageal Squamous Cell Carcinoma
N/A2024-05-30
Not Yet RecruitingA Multicentre Real-world Study of Heptapopal Ethanolamine Tablets in Concurrent/Sequential Radioimmunoinduced
Cancer, Therapy-Related
2024-04-20
RecruitingFruquintinib in Combination With Tislelizumab Followed by Radiotherapy in Esophageal Squamous Cell Carcinoma
Esophageal Neoplasms
Phase 22024-04-01
UnknownA Real-world Study of Adebrelimab Combined With Chemotherapy±Chest Radiotherapy in Patients With Extensive Sta
Extensive Stage Small Cell Lung Cancer
2024-03-26
RecruitingNeoadjuvant Chemoradiation With Nal-IRI and Capecitabine Guided by UGT1A1 Status in Patients With Rectal Cance
Rectal Cancer
Phase 22024-02-01
RecruitingThe Efficacy and Safety of Pyrotinib, Trastuzumab Combined With Taxanes in the Treatment of Trastuzumab-treate
HER2-positive Breast Cancer, Advanced Breast Cancer
Phase 42024-01-02
RecruitingLiposomal Irinotecan and Leucovorin/5-fluorouracil Plus Bevacizumab in Metastatic Colorectal Cancer
Colorectal Cancer
Phase 22024-01-01
RecruitingDalpiciclib Plus AI (Neoadjuvant Endocrine Therapy) Compared With Neoadjuvant Chemotherapy in Early Breast Can
Breast Cancer
Phase 22023-09-30
Not Yet RecruitingA Prospective, Randomized Controlled Study of Cyclophosphamide, Bevacizumab With or Without Envafolimab in Rec
Epithelial Ovarian Cancer
2023-09-01
CompletedSubanesthetic Esketamine for Hemodynamic Stability and Recovery in Elderly Thoracic Surgery Patients
Hemodynamic Instability, Postoperative Recovery, Thoracic Surgery
N/A2023-06-01
RecruitingDurvalumab Combined With Chemoradiotherapy for Limited Stage Small Cell Lung Cancer (Camel-01)
SCLC, Limited Stage
Phase 22023-06-01
UnknownDynamic ctDNA Monitoring in Neoadjuvant Therapy for Esophageal Squamous Cell Carcinoma
Esophageal Squamous Cell Carcinoma
2023-05-22
RecruitingEfficacy and Safety of Tislelizumab for Lung Adenocarcinoma With Asymptomatic Brain Metastatic
Lung Adenocarcinoma
N/A2023-05-01
RecruitingMinimally Residual of Esophageal Cancer 001
Esophageal Carcinoma, Minimal Residual Disease
2023-02-22
RecruitingTrilaciclib in Combination With Chemotherapy in Patients With CDK4/6-Dependent Solid Tumors
Trilaciclib, CDK4/6-dependent Solid Tumors
Phase 12023-01-01
RecruitingToripalimab Combined With Radiotherapy and S-1 for Older Patients With Esophageal Cancer
Esophageal Carcinoma
2022-10-01
UnknownDalpiciclib Combined With Letrozole in Neoadjuvant Treatment of Stage Ⅱ-Ⅲ HR-positive/HER2-negative Breast Can
Solid Tumor
Phase 22022-09-10
RecruitingAdjuvant Therapy of Ensartinib in Stage IB-IIIA ALK-positive Non-small Cell Lung Cancer
Non-small Cell Lung Cancer
Phase 22022-05-01
RecruitingChemotherapy Combined With Bevacizumab Neoadjuvant Therapy for HER2-negative Breast Cancer
Solid Tumor
Phase 42022-03-31
CompletedShort-course Radiotherapy Followed by Tislelizumab + CapeOX in the Treatment for Locally Advanced Rectal Cance
Locally Advanced Rectal Cancer
Phase 22021-09-01
UnknownTargeted Next Generation Sequencing for the Efficacy of Trastuzumab Neoadjuvant Chemotherapy in Breast Cancer
Observational, Prospective
2021-07-01
RecruitingClinical Study of Breast Conserving Surgery Combined With Intraoperative Radiotherapy for Early Breast Cancer
Breast Cancer, HER2-negative Breast Cancer
2020-11-19
UnknownStudy of Anti-PD-1 Antibody Multimodal Combination as First-line Treatment on Time Window of Advanced Solid Tu
Advanced Solid Tumor
Phase 22020-07-16
UnknownA Study of Camrelizumab As Consolidation Therapy After Radical Concurrent Chemoradiotherapy In Locally Advance
Esophageal Cancer
Phase 22020-04-22
Active Not RecruitingNeoadjuvant Chemotherapy With Pyrotinib, Epirubicin and Cyclophosphamide Followed by Taxanes and Trastuzumab f
Breast Cancer
Phase 2 / Phase 32020-03-01
RecruitingNab-paclitaxel Plus Carboplatin Versus Nab-paclitaxel Plus Epirubicin in the Neoadjuvant Therapy for Breast Ca
Breast Cancer, Triple-negative Breast Cancer, Nab-paclitaxel
Phase 22019-11-20
RecruitingNab-paclitaxel Plus Carboplatin Versus Nab-paclitaxel Plus Capecitabine in the Treatment of Advanced Triple-ne
Triple Negative Breast Cancer, Nab-paclitaxel
Phase 22019-11-20
UnknownA Trail of Neoadjuvant Endostar in Combination With Chemotherapy in Breast Cancer
Stage III Breast Cancer
Phase 2 / Phase 32019-08-01
WithdrawnNab-paclitaxel Based Regimens VS Paclitaxel Based Regimens in Neoadjuvant Treatment for TNBC
Triple Negative Breast Cancer
N/A2019-05-10
UnknownPyrotinib in Combination With Nab-paclitaxel in Patients With HER2-positive Advanced Breast Cancer: an Explora
HER2-positive Breast Cancer
Phase 22019-04-30
RecruitingNeoadjuvant Therapy With Nab-paclitaxel and Cisplatin for Locally Advanced Esophageal Squamous Cell Carcinoma
Esophageal Squamous Cell Carcinoma
Phase 22019-04-24
UnknownClinical Research on the Effect of Aspirin on the Disease Free Survival Rate of Esophageal Carcinoma
Aspirin as an Adjuvant Therapy, to Observe Its Effect on the Disease Free Survival Rate of Patients With Esophageal Squamous Cell Carcinoma
EARLY_Phase 12019-04-10
UnknownA Prospective Study of Apatinib Plus Concurrent Neoadjuvant Chemoradiotherapy in Patients With Esophageal Squa
Esophageal Squamous Cell Carcinoma
Phase 22019-03-01
UnknownA Study of Apatinib Plus EGFR-TKI as First Line Treatment in Patients With Non-squamous NSCLC Harboring EGFR M
NSCLC
N/A2018-08-15
Active Not RecruitingImmunotherapy Combined With Chemoradiotherapy for First-line Treatment of Esophageal Squamous Cell Carcinoma(C
ESCC
N/A2018-01-01
TerminatedA Study of Apatinib Plus Radiotherapy and S-1 for Treatment of Refractory or Metastatic Esophageal Squamous Ce
Refractory or Metastatic Esophageal Squamous Cell Carcinoma
Phase 22017-11-01
UnknownApatinib in Neoadjuvant Therapy for Patients With Breast Cancer
Breast Cancer
Phase 2 / Phase 32017-06-01
UnknownProspective, Multicenter, Observational Study of Apatinib Single or Combined Capecitabine for Treatment of Pat
Breast Cancer Metastatic
Phase 22016-11-24
UnknownThe Study of Pegylated Liposomal Doxorubicin Contrast Epirubicin for the Treatment of Diffuse Large B-cell Lym
Diffuse Large B-cell Lymphoma
N/A2016-11-01
UnknownDoxorubicin Hydrochloride Liposome Injection Combination With Cyclophosphamide vs Pirarubicin Combination With
Breast Cancer
Phase 42016-09-01
CompletedA Dose Increase Finding Study of Doxorubicin Hydrochloride Liposome Injection for Patients With Breast Cancer
Breast Cancer
N/A2015-05-01
Active Not RecruitingThe Neoadjuvant Treatment Modalities in Patients With Locally Advanced Esophageal Squamous Cell Carcinoma (NEO
Esophageal Carcinoma
2015-01-01
CompletedNeoadjuvant Chemotherapy With a Combination of Pegylated Liposomal Doxorubicin (Caelyx®) and Paclitaxel in Bre
Breast Cancer
N/A2015-01-01
UnknownClinical Observation of S1 Capsule for Stage Ⅱ-ⅢA Non-small Cell Lung Cancer After Complete Resection
Non-small Cell Lung Cancer Stage Ⅱ, Non-small Cell Lung Cancer Stage ⅢA
Phase 22014-12-01
RecruitingDefinitive Radiotherapy for Cervical and Upper Thoracic Esophageal Cancer (ChC&UES): A Multi-center Real World
Esophageal Neoplasm
2000-01-01