| Recruiting | INHALE-1st: Afrezza® For Youth With Newly-Diagnosed Type 1 Diabetes Type 1 Diabetes Mellitus | Phase 2 | 2026-02-01 |
| Recruiting | A Study to Evaluate Safety, Tolerability and Pharmacokinetics of MNKD-201 in Patients With Idiopathic Pulmonar Idiopathic Pulmonary Fibrosis (IPF) | Phase 1 | 2025-12-22 |
| Terminated | ICoN-1 Phase 3 Study of the Efficacy and Safety of Treatment With MNKD-101, Clofazimine Inhalation Suspension MAC Lung Disease, Treatment Refractory MAC Lung Disease, Mycobacterium Infections, Nontuberculous | Phase 3 | 2024-09-11 |
| Recruiting | A Study to Evaluate Safety, Tolerability and Pharmacokinetics of MKND-201 in Healthy Volunteers Healthy Volunteers | Phase 1 | 2024-05-28 |
| Completed | INHALE-3: Afrezza® Combined With Insulin Degludec Versus Usual Care in Adults With Type 1 Diabetes Diabetes Mellitus, Type 1 | Phase 4 | 2023-07-07 |
| Completed | Afrezza With Basal Combination (ABC): Afrezza® Combined With AID Pump or Insulin Degludec in Adults With Type Type 1 Diabetes | Phase 4 | 2022-03-31 |
| Completed | Afrezza® INHALE-1 Study in Pediatrics Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2 | Phase 3 | 2021-09-29 |
| Completed | Afrezza® Dosing Optimization Study Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2 | Phase 4 | 2021-04-09 |
| Completed | Pharmacokinetics, Safety and Tolerability of Treprostinil Inhalation Powder in Healthy Normal Volunteers Pulmonary Arterial Hypertension | Phase 1 | 2018-03-09 |
| Completed | Afrezza Safety and Pharmacokinetics Study in Pediatric Patients Type 1 Diabetes Mellitus | Phase 2 | 2017-09-28 |
| Completed | PK and PD Within-Subject Variability of a Single Dose of Afrezza Inhaled Technosphere Insulin in Patients With Type 1 Diabetes Mellitus | Phase 1 | 2015-07-01 |
| Completed | Single Dose Clamp Study to Evaluate Concentration-time Profile and Metabolic Activity of 3 Dose Levels of Afre Type 1 Diabetes Mellitus | Phase 1 | 2015-06-01 |
| Completed | Comparison of 30 Units of TI (Technosphere® Insulin) Prepared With Insulin From Two Different Suppliers Healthy Volunteers | Phase 1 | 2013-11-01 |
| Completed | Compare the Same Dosage of Insulin Using a Combination of Cartridges, 30 Units as 2 Cartridges vs. 1 Cartridge Healthy Volunteers | Phase 1 | 2013-08-01 |
| Completed | Comparison of Technosphere Insulin Inhalation Powder & Subcutaneous Rapid-Acting Analog in Subjects With Type Type 1 Diabetes Mellitus | Phase 1 | 2012-03-01 |
| Completed | Healthy Normal Volunteers Looking at Exposure and Effects of Multiple Doses of Technosphere® Insulin (TI) Usin Healthy | Phase 1 | 2011-12-01 |
| Completed | Comparison of Technosphere® Insulin Versus Technosphere Powder (Placebo) in Insulin-Naive Subjects With Type 2 Type 2 Diabetes | Phase 3 | 2011-11-01 |
| Completed | Clinical Trial Evaluating Technosphere® Insulin Versus Insulin Aspart in Subjects With Type 1 Diabetes Mellitu Type 1 Diabetes Mellitus | Phase 3 | 2011-09-01 |
| Completed | Pharmacokinetic Study in Healthy Volunteers Healthy Volunteers | Phase 1 | 2011-01-01 |
| Terminated | Pulmonary Function Substudy for Subjects Enrolled in Studies MKC-TI-161, MKC-TI-162 or MKC-TI-166 Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus | — | 2010-10-01 |
| Terminated | Safety, Immune and Tumor Response to a Multi-component Immune Based Therapy (MKC1106-MT) for Patients With Mel Stage III Melanoma, Stage IV Melanoma | Phase 2 | 2010-10-01 |
| Terminated | Clinical Trial Evaluating the Efficacy and Safety of Technosphere® Inhalation Insulin (TI) Inhalation Powder U Type 2 Diabetes | Phase 3 | 2010-09-01 |
| Terminated | Evaluate Safety of Technosphere® Insulin (TI) in Diabetic Subjects With Moderate Obstructive Pulmonary Disease Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus, Moderate Chronic Obstructive Pulmonary Disease | Phase 3 | 2009-03-01 |
| No Longer Available | Patient Transitioning From Exubera® Inhalation Powder to Technosphere® Insulin Inhalation Powder Type 1 Diabetes, Type 2 Diabetes | — | 2008-10-01 |
| Terminated | Safety and Efficacy of Technosphere® Insulin Inhalation Powder (TI Inhalation Powder)When an Optimal Dose is T Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1 | Phase 2 | 2008-09-01 |
| Completed | A Trial to Determine How Long Insulin and FDKP (the Molecule That Forms Technosphere Particles) Stays in the L Healthy Subjects | Phase 1 | 2008-07-01 |
| Completed | Safety and Immune Response to a Multi-component Immune Based Therapy (MKC1106-MT) for Patients With Melanoma. Advanced Melanoma, Stage III and IV Melanoma | Phase 1 | 2008-06-01 |
| Completed | A Study Designed to Determine if the Pharmacokinetic Disposition of Inhaled Insulin Exposure is the Same for A Asthma, Diabetes Mellitus | Phase 1 | 2008-05-01 |
| Terminated | Safety and Efficacy of Technosphere® Insulin Inhalation Powder and Lantus® Compared to Humalog® and Lantus® Ov Diabetes, Type 1 | Phase 3 | 2008-05-01 |
| Completed | A Study Designed to Determine if the Drugs Albuterol (Salbutamol) and Fluticasone Have an Effect on the Pharma Diabetes Mellitus, Healthy Subjects | Phase 1 | 2008-05-01 |
| Completed | A Study to Determine if Technosphere® Inhalation Powder (FDKP) Causes ECG Changes (QTc) Following the Medicati Healthy Subjects | Phase 1 | 2008-04-01 |
| Completed | A Study Designed to Compare 2 Dose Strengths of TI Inhalation Powder in Adults With Type 1 Diabetes Mellitus a Diabetes Mellitus: Type 1 | Phase 2 | 2008-04-01 |
| Completed | A Study Designed to Determine the Safety and Pharmacological Response ofMKC253 Inhalation Powder in Adults Wit Diabetes Mellitus, Type 2 | Phase 1 | 2008-02-01 |
| Completed | Effects of URI on Diabetic Subjects Utilizing Technosphere Insulin After a Meal Challenge Diabetes Mellitus, Upper Respiratory Infection | — | 2007-12-01 |
| Completed | A Study Comparing Subcutaneous Rapid Acting Insulin and One Formulation of Inhaled Insulin in Subjects With Ty Diabetes Mellitus, Type 2 | Phase 2 | 2007-09-01 |
| Completed | Single Dose, Single Administration Study of Technosphere Inhalation Powder in Diabetic Subjects With Mild or M Mild Nephropathy, Moderate Nephropathy, Diabetes Mellitus | Phase 1 | 2007-08-01 |
| Completed | A 2-Month Safety Follow-Up Trial Type 1 Diabetes, Type 2 Diabetes | — | 2007-05-01 |
| Completed | A First in Human, Single Dose, Safety and Tolerability Study of MKC253 Inhalation Powder in Healthy Adult Male Diabetes Mellitus, Type 2, Healthy Males | Phase 1 | 2007-04-01 |
| Completed | Safety and Immune Response to a Multi-component Immune Based Therapy (MKC1106-PP) for Patients With Advanced C Ovarian, Melanoma, Renal | Phase 1 | 2007-02-01 |
| Completed | A Study to Evaluate Insulin in the Blood After Inhalation of a Dry Powder Insulin Formulation (Called Technosp Chronic Obstructive Pulmonary Disease (COPD) | Phase 1 | 2006-07-01 |
| Terminated | Inhaled Technosphere Insulin in Subjects With Diabetes Mellitus and Asthma Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Asthma | Phase 3 | 2006-06-01 |
| Completed | Efficacy and Safety in Subjects With Type 2 Diabetes Receiving Subcutaneous Basal Insulin and Prandial Inhalat Diabetes Type 2 | Phase 3 | 2006-02-01 |
| Completed | Efficacy & Safety of Inhaled Insulin in Type 1 Diabetes Diabetes, Type I | Phase 3 | 2006-02-01 |
| Completed | Comparison Between Technosphere/Insulin Inhalation Powder Versus Rapid Acting Insulin in Subjects With Type 2 Diabetes Type 2 | Phase 3 | 2005-11-01 |
| Completed | Safety of Inhaled Insulin With Type 1 and Type 2 Diabetes Diabetes, Type 1, Diabetes, Type 2 | Phase 3 | 2005-06-01 |
| Completed | A 3 Month, Randomized, Open Label, Multi-center Study of Technosphere/Insulin Compared to Insulin Aspart in Su Diabetes Mellitus, Type 1 | Phase 2 | 2005-03-01 |
| Completed | Efficacy and Safety of Prandial Inhalation of Technosphere/Insulin in Combination With Metformin or Technosphe Diabetes Mellitus, Type 2 | Phase 3 | 2004-12-01 |
| Completed | Clamp Study Comparing Inhalation of Technosphere®/Insulin in Smokers and Non-Smokers With Type 2 Diabetes Diabetes Type 2 | Phase 2 | 2004-08-01 |
| Completed | 18-Week, Randomized, Double-blind, Placebo Controlled, Forced Titration Study of Patients With Type 2 Diabetes Type 2 Diabetes Mellitus | Phase 2 | 2004-06-01 |
| Completed | An Open-label, Multi-center, International, Three-year, Safety and Tolerability 'Follow on' Trial Type 2 Diabetes Mellitus | Phase 2 | 2004-05-01 |
| Completed | Bioavailability of Technosphere® Insulin Versus Subcutaneous Regular Human Insulin in Type 2 Diabetes Type 2 Diabetes Mellitus | Phase 2 | 2004-02-01 |
| Completed | Study of the Efficacy and Safety of Inhaled Technosphere Insulin in Patients With Type 2 Diabetes Type 2 Diabetes Mellitus | Phase 2 | 2003-12-01 |
| Completed | To Compare the Effect of Inhaled Insulin With Subcutaneously Injected Insulin in Subjects With Type 2 Diabetes Diabetes Mellitus, Type 2 | Phase 2 | 2003-10-01 |
| Completed | Vaccine Therapy in Treating Patients With Stage IV Melanoma Melanoma (Skin) | Phase 1 / Phase 2 | 2002-01-01 |
| Completed | Vaccine Therapy in Treating Patients With Stage IV Melanoma Melanoma (Skin) | Phase 1 | 2000-07-01 |
| Completed | Comparison of the Effect on the Glucose Infusion Rates Between Inhaled Technosphere Insulin and a Subcutaneous Healthy | Phase 1 | 1999-08-01 |