NCT01937208

Comparable Study of Different Radiation Dose in Esophageal Carcinoma

A Prospective, Randomised Phase 3 Study of High-dose Versus Standard-dose Radiation of Inoperable Esophageal Carcinoma Treated With Concurrent Chemoradiation

• Status: Unknown
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 300 (estimated)
• Sponsor: Zhejiang Cancer Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Radiation therapy plus concurrent chemotherapy is now the standard therapy for patients with localized carcinoma of the esophagus selected for nonsurgical treatment. The standard radiation dose is 50-50.4Gy/1.8-2.0Gy/F.All of this were based on 2D radiation technology. Entering new century, 3D-CRT or IMRT has used on esophageal cancer. In China,the recommend radiation dose of concurrent chemoradiation was 60Gy. The study is a clinical phase III, randomized trial to compare the different radiation dose(60Gy vs 50Gy) of concurrent chemoradiation using 3D-CRT or IMRT in patients with unresectable esophageal carcinoma.

Conditions

• Esophageal Carcinoma

Interventions

Type	Name	Description
RADIATION	intensity modulated radiation therapy in both arms
DRUG	concurrent chemotherapy with radiation	docetaxel plus cisplatin were used weekly in both arms

Timeline

• Start date: 2013-08-01
• Primary completion: 2015-08-01
• Completion: 2017-07-01
• First posted: 2013-09-09
• Last updated: 2013-09-09

Locations

1 site across 1 country: China