| Not Yet Recruiting | A Study Comparing Two Immunotherapy Options for Human Papillomavirus Positive HPV-Positive Head and Neck Cance NCT07179315 | University of Chicago | Phase 2 |
| Not Yet Recruiting | TheraT® Vectors (Vaccines) Combined With Chemotherapy to Treat HPV16 Head and Neck Cancers NCT05108870 | University of Chicago | Phase 1 / Phase 2 |
| Not Yet Recruiting | Protein Supplementation for Radiation- Induced Oral Mucositis in Head and Neck Cancer Patients Receiving Radio NCT07531563 | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | N/A |
| Not Yet Recruiting | Study of a 1-Millimeter Resolution Clinical Positron Emission Tomography (PET) System in Head and Neck Cancer NCT04662554 | Stanford University | N/A |
| Not Yet Recruiting | Staph Nasal Decolonization to Improve Function and Feeding: A Randomized Clinical Trial (SNIFF). NCT07524894 | David Palma | Phase 2 |
| Not Yet Recruiting | This Protocol Focuses on the Factors That Influence Survival, the Development of Complications and the Quality NCT07066878 | IRCCS San Raffaele | — |
| Not Yet Recruiting | A Single Arm Phase II Trial in p16-positive Oropharynx Cancer of Selective Dose De-escalation of nodAl VolumEs NCT07418034 | University of Maryland, Baltimore | Phase 2 |
| Not Yet Recruiting | H&N NEO-COMBAT XL: Neoadjuvant XL-092 (Zanzalintinib) and Pembrolizumab (Keytruda) in Surgically Resectable, H NCT07484139 | UNC Lineberger Comprehensive Cancer Center | Phase 2 |
| Not Yet Recruiting | A Machine Learning-Based Risk Prediction Model for Head and Neck Cancerous Lesions NCT07532538 | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | — |
| Recruiting | Prehabilitation Protocol for Head and Neck Cancer Patients NCT07318220 | University of Miami | N/A |
| Not Yet Recruiting | Ph. I/II Sodium Thiosulfate for OtoProtection During Cisplatin (STOP-CIS) NCT07407582 | University of Arizona | Phase 1 / Phase 2 |
| Not Yet Recruiting | The Safety, Dosimetry and Efficacy of 177Lu-INN805 in Patients With Malignant Solid Tumors NCT07459283 | FindCure Biosciences (ZhongShan) Co., Ltd. | EARLY_Phase 1 |
| Not Yet Recruiting | Evolution of Masticatory Function, Orofacial Functions and Quality of Life of Patients Treated for Cancers of NCT07471451 | University Hospital, Clermont-Ferrand | N/A |
| Recruiting | A Phase 1 Study of EPI-326 in EGFR-mutant NSCLC and HNSCC NCT07462377 | EpiBiologics | Phase 1 |
| Not Yet Recruiting | SPECT-CT Guided ELEctive Contralateral Neck Treatment in Lateralized Oropharyngeal Cancer NCT07241273 | UNICANCER | N/A |
| Recruiting | Study of High-Precision Evaluation of Molecular ResiduaL Disease Through a PlatfOrm for Cancer TracKing and In NCT07524114 | University Health Network, Toronto | — |
| Recruiting | Pembrolizumab Plus Ultrasound-Induced Microbubble Cavitation in Head and Neck Cancer NCT07501650 | Thomas Jefferson University | Phase 1 |
| Recruiting | Development and Application of a Nurse-Led Preemptive Symptom Management Protocol for Head and Neck Cancer Pat NCT07467083 | West China Hospital | Phase 3 |
| Not Yet Recruiting | PDT For Induction Therapy For Head And Neck Cancer NCT07214987 | Massachusetts General Hospital | Phase 2 |
| Recruiting | Postoperative Radiotherapy Combined With Nimotuzumab Followed by Benmelstobart in High-Risk Patients With Head NCT07445048 | Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University | Phase 3 |
| Recruiting | Neoadjuvant Chemotherapy and Programmed Cell Death Protein 1(PD-1) Inhibition for Head and Neck Cancer Treatme NCT07209189 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Phase 2 |
| Not Yet Recruiting | Skin Color Matching in Head and Neck Reconstructive Surgery NCT07431099 | Yale University | N/A |
| Not Yet Recruiting | Reducing Skin Side Effects in Patients Receiving Radiation on Tomotherapy NCT07357506 | King Faisal Specialist Hospital & Research Center | N/A |
| Recruiting | An Oncology Nurse AI Agent to Reduce Cancer Distress During Radiotherapy NCT06636188 | The University of Hong Kong | N/A |
| Not Yet Recruiting | SL-28 for Advanced Solid Tumours NCT07341737 | Second Life Therapeutics | Phase 1 / Phase 2 |
| Recruiting | Sparing Parotid Ducts Via MRI Sialography for Reduced Patient-Reported Xerostomia NCT07278557 | UNC Lineberger Comprehensive Cancer Center | Phase 2 |
| Enrolling By Invitation | DENTOFACIAL-PBT Stage 2 - Feasibility Study NCT07057284 | Manchester University NHS Foundation Trust | — |
| Recruiting | Photobiomodulation in Head and Neck Cancer-Related Chronic Lymphedema NCT06837480 | Abramson Cancer Center at Penn Medicine | N/A |
| Recruiting | Improving Dental Care for Patients With Head and Neck Tumors NCT07328347 | University Medical Center Goettingen | N/A |
| Recruiting | Compare Radiotherapy Plus Nimotuzumab Versus Radiotherapy Alone in Platinum-ineligible Patients With Locoregio NCT07333274 | Shandong Cancer Hospital and Institute | Phase 3 |
| Not Yet Recruiting | Assessing Spinal Accessory Nerve Recovery After Post-operative Electrical Stimulation NCT07074392 | McMaster University | N/A |
| Not Yet Recruiting | Decitabine and Nivolumab in Participants With Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Nec NCT07216833 | Kyunghee Burkitt, DO, PhD | Phase 1 |
| Not Yet Recruiting | Compartmentalized Postoperative Radiotherapy in Head and Neck Cancer NCT07058805 | Olgun Elicin | Phase 2 |
| Recruiting | Velopharyngeal Dysfunction in Head & Neck Cancer Patients, Pilot Study NCT07264036 | Vanessa Torrecillas | N/A |
| Recruiting | Riluzole For Preventing Cognitive Dysfunction in Ca Pts Receiving Chemo (REFOCUS): Pilot Trial NCT07447050 | University of California, Irvine | Phase 2 |
| Recruiting | Study to Assess the Effect of OCT-598 in Patients With Advanced Solid Tumors NCT07358806 | Oscotec Inc. | Phase 1 |
| Recruiting | Tongue Proactive Strengthening Exercise Program Following Partial/Hemi Glossectomy and Reconstruction NCT07110142 | Case Comprehensive Cancer Center | N/A |
| Recruiting | Axoguard HA Plus Nerve Protector to Reduce Post-operative Neck and Shoulder Dysfunction in Patients Undergoing NCT07283861 | Matthew Spector | N/A |
| Recruiting | A Phase 1b/2 Study of the Safety and Efficacy of the Monoclonal Antibody OM-RCA-01 in Patients With Metastatic NCT07292168 | Kidney Cancer Research Bureau | Phase 1 / Phase 2 |
| Withdrawn | Intraoperative Identification and Stimulation of the Glossopharyngeal Nerve NCT05754216 | Vanderbilt University Medical Center | N/A |
| Not Yet Recruiting | SCINTIX [BgRT} Using RMRS in Solid and Soft Tissue Tumors NCT06634706 | RefleXion Medical | N/A |
| Recruiting | FL-261 Imaging for Cancer Diagnosis and Staging NCT07510321 | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | — |
| Recruiting | Role of the Immune System in Preventing Laryngeal Cancer NCT07508319 | European Institute of Oncology | — |
| Recruiting | To Assess the Correlation of High-resolution Specimen PET-CT Imaging, Using the XEOS AURA 10 PET-CT, With the NCT06970275 | XEOS Medical | — |
| Recruiting | Nimotuzumab Combined With Toripalimab and Chemotherapy for Locally Advanced Tonsillar Cancer NCT07353723 | Tang-Du Hospital | Phase 2 |
| Recruiting | Performance of 18F-FDG Micro-PET-CT in the Assessment of Surgical Margins in Head and Neck Cancer NCT07285564 | Centre Henri Becquerel | N/A |
| Recruiting | Phase I Study of Preconditioning Radiation Therapy With IL-15 Transduced TGFBR2 KO CAR.TROP2-engineered Cord B NCT07101432 | M.D. Anderson Cancer Center | Phase 1 |
| Recruiting | Microbiota-guided Radiotherapy for Head and Neck Cancer NCT07253402 | Fondazione IRCCS Istituto Nazionale dei Tumori, Milano | — |
| Recruiting | Iparomlimab and Tuvonralimab Plus Hypofractionated Radiotherapy and Chemotherapy for HAHNSCC NCT07447570 | Second Affiliated Hospital, School of Medicine, Zhejiang University | Phase 2 |
| Recruiting | Phase I/ II Trial Combining PD-1 Inhibition and Neoadjuvant Proton or Photon Radiation Therapy in Recurrent He NCT07213934 | University of Cincinnati | Phase 1 / Phase 2 |
| Recruiting | Response-Adaptive Treatment in Untreated Locoregional HPV-Negative Head and Neck Cancer NCT07065630 | University of Chicago | Phase 2 |
| Recruiting | Apixaban or Enoxaparin After Head and Neck Cancer Surgery NCT07189897 | Kiranya Arnold | Phase 4 |
| Completed | Kaltenborn Versus Active Release on Temporomandibular Joint Dysfunction NCT07151469 | MTI University | N/A |
| Not Yet Recruiting | Improved Oral Health in Head and Neck Cancer Survivors NCT07173270 | Uppsala University | N/A |
| Not Yet Recruiting | Dual Energy CT - a Tool for Delineation of Tumor and Organs at Risk in Radiotherapy NCT07185958 | Aalborg University Hospital | — |
| Recruiting | DESTINY-PANTUMOUR04 NCT07124000 | AstraZeneca | — |
| Recruiting | Contrast-enhanced Ultrasound for Sentinel Node Detection NCT07310758 | The Netherlands Cancer Institute | Phase 2 / Phase 3 |
| Recruiting | Supporting Treatment Resilience With Optimized Nutrition and Guided Exercise in Head and Neck Cancer Patients NCT07160296 | Renown Health | N/A |
| Completed | Stabilizer Pressure Biofeedback on Neck Dysfunction NCT07313189 | Cairo University | N/A |
| Not Yet Recruiting | Home-Based Photo-Biomodulation for Management of Lymphoedema and Radiation Fibrosis in Patients After Head and NCT07139782 | Peter MacCallum Cancer Centre, Australia | N/A |
| Not Yet Recruiting | [Ga-68]MTP220 PET for Biodistribution and Efficacy in Pancreatic Cancer and Head and Neck Cancers NCT07026981 | Qiubai Li | EARLY_Phase 1 |
| Not Yet Recruiting | A Randomized Controlled Study on the Improvement of Medical Experience for Patients With Radiation-induced Oro NCT07126457 | Nanfang Hospital, Southern Medical University | N/A |
| Recruiting | Comparative Study of New Classification and Traditional Classification of Radioactive Oropharyngeal Mucositis NCT06307327 | Nanfang Hospital, Southern Medical University | — |
| Not Yet Recruiting | Health Oriented Protocol for Epidermal Radiodermatitis NCT07129525 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | — |
| Enrolling By Invitation | A Long-Term Follow-Up Study of Participants Treated With A2 Biotherapeutics (A2 Bio) Gene Therapy (GT) Product NCT06885424 | A2 Biotherapeutics Inc. | — |
| Recruiting | A Study of [225Ac]Ac-AKY-1189 in Patients With Solid Tumors NCT07020117 | Aktis Oncology, Inc. | Phase 1 |
| Recruiting | A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors NCT07090499 | Pfizer | Phase 1 |
| Recruiting | A First in Human Study of ALX2004 With Advanced or Metastatic Selected Solid Tumors NCT07085091 | ALX Oncology Inc. | Phase 1 |
| Not Yet Recruiting | Safety, Tolerability, PK, and Efficacy of CD-001 in Advanced Head & Neck Cancers NCT07072325 | West China Hospital | Phase 1 |
| Withdrawn | Sparing Parotid Ducts Via MRI Sialography for Reduced Patient Reported Xerostomia NCT06276946 | UNC Lineberger Comprehensive Cancer Center | N/A |
| Active Not Recruiting | Local Injection Methylene Blue Combined With Radiation in HNSCC Patients NCT07435415 | China Medical University Hospital | EARLY_Phase 1 |
| Recruiting | Circulating Tumor Cell Counts in Postoperative ENE-Positive Oral Cavity Cancer Patients After Adjuvant CCRT NCT07296250 | Chang Gung Memorial Hospital | N/A |
| Recruiting | Sample Collection for Ongoing Research and Product Evaluation Study NCT07318051 | Natera, Inc. | — |
| Withdrawn | Study of Front Line Pembrolizumab and Valemetostat in PD-L1 Positive, HPV-Negative Recurrent/Metastatic Squamo NCT05879484 | National Cancer Institute (NCI) | Phase 1 / Phase 2 |
| Recruiting | Head and Neck Advanced Research for Multi-Omics and Optimized Immunotherapy NCT07211139 | Samsung Medical Center | — |
| Terminated | Mental Health App for Cancer Survivors Study NCT06472726 | University of Wisconsin, Madison | N/A |
| Recruiting | Plasma Calcitonin Gene-Related Peptide (CGRP) Levels in Patients With Head and Neck Malignancies Undergoing Ra NCT07029373 | West China Hospital | — |
| Recruiting | Nutritional Status of Head and Neck Cancer Patients NCT07068711 | Marmara University | — |
| Withdrawn | Implementation of a Standardized Tracheostomy Education Discharge Protocol NCT04741256 | Case Comprehensive Cancer Center | N/A |
| Not Yet Recruiting | Cisplatin-induced Cochlear and Vestibular Damage in Head and Neck Cancer NCT06929468 | Simon Jäger | — |
| Not Yet Recruiting | Immunonutrition Effects on Nutrition and Immunity in HNC During Radiotherapy NCT07017218 | First Affiliated Hospital of Chongqing Medical University | N/A |
| Not Yet Recruiting | Laser Acupoints Stimulation on Xerostomia Related Chemoradiotherapy for Head and Neck Cancer Patients NCT07029854 | Cairo University | N/A |
| Active Not Recruiting | NT219 Combined With Standard of Care Biologic Therapy in Recurrent/Metastatic Head and Neck Squamous Cell Carc NCT06919666 | University of Colorado, Denver | Phase 1 / Phase 2 |
| Withdrawn | Quality of Life Assessment of Radiotherapy in Recurrent Head and Neck Cancer NCT05850663 | University of Oklahoma | N/A |
| Recruiting | Boron Neutron Capture Therapy With B10 L-BPA for Unresectable Recurrent Head and Neck Cancers NCT06952868 | China Medical University Hospital | Phase 2 |
| Recruiting | Microbiome in Head and Neck Squamous Cell Carcinoma NCT05837221 | University of Colorado, Denver | — |
| Recruiting | Intratumoral Delivery of Viral Replicon (saRNA) Particles Expressing IL-12 in Head and Neck Cancer NCT06736379 | VLP Therapeutics | Phase 1 |
| Not Yet Recruiting | Assessing Perfusion of Osteotomized Scapula and Lat Flap NCT06811532 | Western University, Canada | — |
| Recruiting | Survivorship After HNC: A Randomized Controlled Trial Evaluating Patient Care and Adherence to Follow-up NCT06127784 | Western University, Canada | N/A |
| Recruiting | Thermoradiotherapy for Locally Advanced Head and Neck Cancer Patients NCT06761937 | Erasmus Medical Center | Phase 1 |
| Recruiting | PIRATES: Image-guided Hyper-fractioned Dose-escalation With Proton Therapy for Head and Neck Cancer NCT06446713 | University Medical Center Groningen | Phase 1 |
| Not Yet Recruiting | In-depth Characterization of Circulating and Infiltrating Immune Subsets and Tumor Cells in Cancer Patients NCT06827639 | Assistance Publique Hopitaux De Marseille | — |
| Recruiting | Lead-212 PSV359 Therapy for Patients With Solid Tumors NCT06710756 | Perspective Therapeutics | Phase 1 / Phase 2 |
| Recruiting | Head and Neck Cancer Omics/Integrated Precision Medicine (HOPE) NCT07190573 | Samsung Medical Center | — |
| Recruiting | Predicting Response to Immunotherapy From Analysis of Live Tumor Biopsies NCT07327489 | Elephas | — |
| Recruiting | Ovarian-Sparing Adaptive Radiotherapy in Young Adult Women NCT06904365 | Washington University School of Medicine | — |
| Enrolling By Invitation | Effect of Transcutaneous Electrical Nerve Stimulation or Acupressure on Pain in Patients With Head and Neck Ca NCT07051265 | Kaohsiung Veterans General Hospital. | N/A |
| Not Yet Recruiting | Lipiodal Injection Technique for Free Flap Sparing Adjuvant RT Planning in HNC NCT06806189 | Western University, Canada | EARLY_Phase 1 |
| Not Yet Recruiting | Autologous T Cells Targeting HPV16 HPV18 & Survivin in Patients With R/R HPV-related Oropharyngeal Cancers NCT05582590 | NexImmune Inc. | Phase 1 |
| Recruiting | Antibiotic Treatment Effects on Intratumoral Bacteria Modulation in Surgical Patients With Oral Cancer NCT06627270 | Case Comprehensive Cancer Center | Phase 2 |
| Recruiting | Brodalumab in the Treatment of Immune-Related Adverse Events NCT06673329 | Brian Henick, MD | Phase 1 |
| Recruiting | Feasibility of Prospective Surveillance and Early Physical Therapy for Trismus NCT06531083 | University of Alberta | N/A |
| Withdrawn | Effect of Pre-operative Virtual Visits on Patients With Head and Neck Cancer Undergoing Surgery NCT06094621 | University of Michigan Rogel Cancer Center | — |
| Recruiting | Noninvasive Intratumor Heterogeneity Evaluation in HNSCC NCT07027280 | First Affiliated Hospital of Chongqing Medical University | — |
| Active Not Recruiting | COPD Care Pathway Among Patients With Cancer NCT05984680 | Wake Forest University Health Sciences | — |
| Recruiting | Heavy Strength Training in Head and Neck Cancer Survivors NCT06289049 | University of Alberta | Phase 2 |
| Recruiting | Impact of Photobiomodulation (PBM) on Biomarkers of Radiation Lymphedema and Fibrosis in Head and Neck Cancer NCT06708754 | NYU Langone Health | N/A |
| Not Yet Recruiting | A Phase II Study to Evaluate the Efficacy and Safety of Salvage Preoperative PD-1 Inhibitor Combined with Chem NCT06793761 | Beijing Tongren Hospital | Phase 2 |
| Active Not Recruiting | Longitudinal Oral Health Changes After Head and Neck Radiotherapy NCT07394842 | Ain Shams University | — |
| Recruiting | Carboplatin + Paclitaxel + Cetuximab (PCC) After Failure of Pembrolizumab +/- First-line Chemotherapy in Recur NCT06725368 | Centre Paul Strauss | Phase 2 |
| Recruiting | Postoperative Radiotherapy for Intermediate- and High-risk Patients With HNSCC Greater Than 6 Weeks After Surg NCT06607406 | Wake Forest University Health Sciences | N/A |
| Withdrawn | Neoadjuvant Radiotherapy Plus Targeted Therapy and Immunotherapy vs. Targeted Therapy Plus Immunotherapy in Re NCT06804850 | West China Hospital | Phase 2 |
| Recruiting | Pilot Study of Management of Facial Paralysis in the Oncologic Patient: Nerve Transfer Techniques to Improve F NCT06667427 | M.D. Anderson Cancer Center | N/A |
| Completed | Quality of Life Before and After Radiotherapy in Patients With Head and Neck Cancer NCT06807697 | University of Turin, Italy | — |
| Recruiting | Surufatinib Combined with Envolizumab As Second-line Treatment for Recurrent/Metastatic HNSCC NCT06876844 | Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University | Phase 2 |
| Recruiting | Fatigue and Molecular Mechanisms in Cancer Patients Receiving CCRT NCT06633224 | University of California, San Francisco | — |
| Not Yet Recruiting | Application of MRI Radiomics Features in Neoadjuvant Therapy of Head and Neck Squamous Cell Carcinoma NCT06755567 | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | — |
| Recruiting | Trop2-targeted immunoPET Imaging of Solid Tumors NCT06851663 | RenJi Hospital | Phase 2 / Phase 3 |
| Recruiting | Ixovex-1 Single Agent and Combination Therapy NCT06549946 | Psivac Ltd | Phase 1 / Phase 2 |
| Recruiting | Clinical Trial of HG146 Administered to Participants with Adenoid Cystic Carcinoma NCT06781567 | HitGen Inc. | Phase 2 |
| Recruiting | Repurposing Riluzole for Cancer-Related Cognitive Impairment: A Pilot Trial NCT06580002 | University of California, Irvine | Phase 2 |
| Recruiting | Acupressure on Xerostomia in Head and Neck Cancer Patients NCT06465628 | The University of Hong Kong | N/A |
| Active Not Recruiting | Development and Evaluation of a Self-Management Model for Cancer Rehabilitation NCT06674499 | Xingchen Peng | N/A |
| Recruiting | Efficacy of Botox Injection of the Masticatory Muscles in Head &Neck Cancer Patients with Trismus After Radiot NCT06734598 | National Taiwan University Hospital | Phase 4 |
| Recruiting | Non-invasive Preoperative Tissue Evaluation in Head and Neck Tumor Patients Using Multispectral Optoacoustic T NCT06716892 | University of Erlangen-Nürnberg Medical School | — |
| Withdrawn | Functional and Molecular Characterization of Treatment Response in Tumors in the Oral Cavity Using Optical Spe NCT04272294 | University of Arkansas | N/A |
| Recruiting | Impact of Early Response to First-line Anti-PD-1 Monotherapy in Patients With Recurrent and/or Metastatic (R/M NCT07448727 | University of Rome Tor Vergata | — |
| Active Not Recruiting | Impact of the Oral Microbiota on Relapse in HNSCC Patients NCT06807034 | Institut Sainte Catherine | Phase 4 |
| Recruiting | Invert-Prospective Phase II Randomized Trial of Involved Nodal Versus Elective Neck RadioTherapy NCT06477692 | University of Texas Southwestern Medical Center | Phase 2 |
| Recruiting | Intraoral Hypothermia Device for Preserving Taste During Radiation NCT06579248 | Henry Ford Health System | EARLY_Phase 1 |
| Terminated | A Study to Learn About PF-07921585 Alone or With Other Anti-cancer Medicines in People With Cancer NCT06580938 | Pfizer | Phase 1 |
| Not Yet Recruiting | Predictors of Acute Toxicity and Flap Failure After Adjuvant Treatment for Locally Advanced Head and Neck Canc NCT06661265 | IRCCS San Raffaele | — |
| Not Yet Recruiting | Head and Neck Cancer Patients With Oral Mucositis Treated With Ketamine Oral Rinse NCT06660017 | University of Oklahoma | Phase 2 |
| Recruiting | Evaluation of On-Couch CBCT Image Quality NCT06576908 | Varian, a Siemens Healthineers Company | N/A |
| Completed | Enhanced Assistance During Radiotherapy for Unmet Essential Needs NCT06582849 | Washington University School of Medicine | N/A |
| Recruiting | Manual Therapy on Oral Opening, Swallow Function and Upper Quarter Mobility on Head and Neck Cancer Survivors NCT06148077 | Universidad de La Frontera | N/A |
| Recruiting | U87 CAR-T in Patients With Advanced Head and Neck Tumors NCT06614686 | Shanghai Unicar-Therapy Bio-medicine Technology Co.,Ltd | Phase 1 |
| Recruiting | Effect of Prehabilitation on Head and Neck Cancer Patients NCT06593639 | Laura Deborah Locati | N/A |
| Terminated | DOLPHIN-VIVO: Diagnosis Of LymPHoma IN Vivo (In Vivo Phase) NCT05010369 | University of Exeter | N/A |
| Recruiting | The Hypotension Prediction Index in Free Flap Transplant in Head and Neck Surgery. NCT05738603 | Jakub Szrama | N/A |
| Not Yet Recruiting | Exploratory Study of EBV DNA Titre Clearance Whilst on Proton Beam Therapy NCT06480903 | The Christie NHS Foundation Trust | — |
| Recruiting | Internet-based Support for Informal Caregivers of Patients With Head and Neck Cancer - Carer eSupport NCT06307418 | Uppsala University | N/A |
| Recruiting | RAdiotherapy With FDG-PET Guided Dose-PAINTing Compared With Standard Radiotherapy for Primary Head and Neck C NCT06297902 | Oslo University Hospital | N/A |
| Not Yet Recruiting | Effects of Minimal-Flow Sevoflurane and Multimodal Analgesia in Head and Neck Cancer Surgery NCT06521697 | National Taiwan University Hospital | Phase 4 |
| Enrolling By Invitation | PA.RI.GE. Study. The Prognostic Role of Inflammatory Circulating Biomarkers in HNSCC: a Prospective Multicentr NCT06809673 | Ospedale Policlinico San Martino | — |
| Completed | Low-dose Radiotherapy Plus Tislelizumab in Combination With Afatinib for Neoadjuvant Treatment of Surgically R NCT06494189 | West China Hospital | Phase 1 |
| Active Not Recruiting | Evaluation of Improved Onboard Patient Imaging NCT06187103 | Varian, a Siemens Healthineers Company | N/A |
| Recruiting | Atorvastatin to Reduce Cisplatin-Induced Hearing Loss Among Individuals With Head and Neck Cancer NCT04915183 | National Institute on Deafness and Other Communication Disorders (NIDCD) | Phase 2 |
| Completed | WeCanManage. An mHealth Self-management Tool NCT06185738 | University of Illinois at Chicago | N/A |
| Recruiting | Novel Hypoxia Imaging for Head and Neck Cancer: Imaging Phenotype for Personalized Treatment NCT06108089 | University of Utah | — |
| Active Not Recruiting | Using an End-of-life Conversation Game to Engage Patients With Cancer in Advance Care Planning: Phase 2 NCT06384417 | Milton S. Hershey Medical Center | N/A |
| Recruiting | Induction IBI110 and Sintilimab with Chemotherapy in LA HNSCC NCT06494943 | Fudan University | Phase 1 / Phase 2 |
| Recruiting | Implementing the NYU Electronic Patient Visit Assessment (ePVA) for Head and Neck Cancer In Rural and Urban Po NCT06030011 | The University of Texas Health Science Center, Houston | N/A |
| Recruiting | Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid Tumors NCT06239194 | ModeX Therapeutics, An OPKO Health Company | Phase 1 / Phase 2 |
| Completed | Technology-based Symptom Monitoring Intervention for Locally Advanced Head and Neck Cancer Patients NCT06385587 | Aptar Digital Health | — |
| Not Yet Recruiting | Early Detection of Esophageal Squamous Cancer With the Capsule Sponge Device NCT06418516 | Centre of Postgraduate Medical Education | N/A |
| Recruiting | Exercise and Nutritional Prehabilitation for Head and Neck Cancer Patients NCT06722508 | University of California, Davis | N/A |
| Active Not Recruiting | A Basket Study of Customized Autologous TCR-T Cell Therapies in Patients With Locally Advanced (Unresectable) NCT05973487 | TScan Therapeutics, Inc. | Phase 1 |
| Recruiting | Psychological and Psychiatric prOfile in Glioblastoma and Head and Neck Cancer NCT06385132 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | — |
| Not Yet Recruiting | Tirelizumab in Combination With Carboplatin and Polymeric Micellar Paclitaxel for Neoadjuvant Therapy in cN+ H NCT06366945 | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | Phase 2 |
| Recruiting | A Phase 2a, Single-dose, Open-label Study to Evaluate Diagnostic Performance and Safety of Pegsitacianine, an NCT05576974 | University of Texas Southwestern Medical Center | Phase 2 |
| Recruiting | PromotinG Lung Cancer screenIng Awareness and Implementation in Hispanics/Latinx Head and Neck canceR Survivor NCT06124508 | University of Miami | N/A |
| Recruiting | Autologous CAR-T Cells Targeting CSPG4 in Relapsed/Refractory HNSCC NCT06096038 | UNC Lineberger Comprehensive Cancer Center | Phase 1 / Phase 2 |
| Recruiting | A Trial Evaluating Omission of Radiotherapy to Regional Lymphatic's NCT07528495 | All India Institute of Medical Sciences | Phase 2 / Phase 3 |
| Not Yet Recruiting | Discovering Factors in Head and Neck Cancer Patients' Clinical Study Experiences NCT05801770 | Power Life Sciences Inc. | — |
| Not Yet Recruiting | Efficacy and Toxicity of Docetaxel as a Radiosenstizer in Head and Neck Cancer NCT06360978 | Assiut University | Phase 2 |
| Recruiting | Effect of Physical Activity Program on Sedentary of Patients With Upper Aerodigestive Tract Cancer NCT06184880 | Centre Hospitalier de Valence | N/A |
| Unknown | Study of WM-A1-3389 in Participants With Advanced or Metastatic Solid Tumors and Non-Small Cell Lung Cancer (M NCT05872867 | Wellmarker Bio | Phase 1 |
| Recruiting | Selective Adjuvant Therapy for HPV-mediated Oropharynx SCCs Based on Residual Circulating Tumor DNA Levels (SA NCT06088381 | University of Maryland, Baltimore | Phase 2 |
| Recruiting | Profiling and Targeting Epigenetic Marks to Improve Diagnosis and Therapeutic Approaches in Head and Neck Canc NCT06706973 | European Institute of Oncology | — |
| Not Yet Recruiting | RADA16 for Reducing Drain Output Trajectory Following Neck Dissection NCT06178237 | St. James's Hospital, Ireland | N/A |
| Unknown | Comparing Radiotherapy Immobilization Systems for Anxious HNC Patients NCT06257121 | Centre hospitalier de l'Université de Montréal (CHUM) | N/A |
| Unknown | Continuous Local-anesthetic Wound Infusion for Neck Dissection NCT06201039 | Sixth Affiliated Hospital, Sun Yat-sen University | N/A |
| Recruiting | Contrast Between Traditional Regression Model and AI in Predicting Prolonged Stay Stay After Head and Neck Tum NCT06570486 | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | — |
| Recruiting | A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors NCT06172478 | Daiichi Sankyo | Phase 2 |
| Recruiting | GM103 Intratumoral Injection in Patients With Locally Advanced, Unresectable, Refractory and/or Metastatic Sol NCT06265025 | GeneMedicine Co., Ltd. | Phase 1 / Phase 2 |
| Recruiting | Impact in Head and Neck Oncology of Support by a Nurse in the Patient's Care Pathway NCT06203808 | University Hospital, Toulouse | — |
| Recruiting | PD-L1 t-haNK, NAI IL-15sa and Cetuximab for Recurrent, Metastatic HNSCC NCT06239220 | Glenn J. Hanna | Phase 2 |
| Active Not Recruiting | A Study to Test Different Doses of BI 765049 Alone and in Combination With Ezabenlimab in Asian People With Ad NCT06091930 | Boehringer Ingelheim | Phase 1 |
| Unknown | Study of the Role of Oncostatin M in Head and Neck Squamous Cell Carcinoma NCT06199947 | Poitiers University Hospital | N/A |
| Recruiting | Plasma SAA1 Levels in Predicting Response to Radiotherapy-induced Oral Mucositis NCT06307314 | Nanfang Hospital, Southern Medical University | — |
| Recruiting | Evaluation of the Medical Benefit of Spa Therapy on Fibrosis After Radiotherapy for Breast Cancer or UADT (Upp NCT05874492 | Association Francaise pour la Recherche Thermale | N/A |
| Recruiting | Adaptive Radiotherapy in Head and Neck Tumor Patients NCT06216171 | University Hospital, Essen | N/A |
| Terminated | Study of Xevinapant With Radiation and Chemotherapy for Patients With Head and Neck Cancer NCT06110195 | University of Chicago | Phase 1 |
| Terminated | Phase 1b Safety Study of Xevinapant, Weekly Cisplatin, and RT in Participants With Unresected LA SCCHN (Hyperl NCT06056310 | EMD Serono Research & Development Institute, Inc. | Phase 1 |
| Completed | Mind Over Matter for Black and African American Women: A Single Arm Trial Examining Feasibility and Acceptabil NCT06168825 | Inova Health Care Services | — |
| Recruiting | MRI Guided Radiotherapy and Radiobiological Data: the ISRAR Database (Irm Sequences for Radiobiological Adapta NCT06041555 | Hospices Civils de Lyon | — |
| Withdrawn | Mood Disorders in Head and Neck Cancer Patients NCT04977271 | University of Alabama at Birmingham | Phase 4 |
| Recruiting | Use of PET-MR in Head and Neck Cancer Patients - Diagnostic and Therapeutic Applications NCT06032663 | Sheffield Teaching Hospitals NHS Foundation Trust | N/A |
| Unknown | Optimising Patient Experience in Head and Neck Radiotherapy NCT06327139 | Irish Research Radiation Oncology Group | Phase 3 |
| Recruiting | Response Adaptive Radiotherapy Following Immunotherapy-based Induction for Non-HPV Related HNSCC NCT06345287 | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | Phase 2 |
| Not Yet Recruiting | Clinical Study to Evaluate Safety and Dosing of CA9hu-1 in Patients With Advanced Solid Tumours NCT05698238 | Mabpro, a.s. | Phase 1 |
| Unknown | Profiles of Expression in HPV+ Versus HPV Head and Neck Cancers NCT06133790 | GCS Ramsay Santé pour l'Enseignement et la Recherche | — |
| Withdrawn | A Study of Concurrent Chemoradiation in Combination With or Without PD1 Inhibitor AB122 Adenosine 2a Receptor NCT04892875 | Jennifer Choe | Phase 1 |
| Active Not Recruiting | The Effect of Hydrogen Water in Oral Mucositis in Head and Neck Cancer Patients After Therapy NCT05913895 | Kaohsiung Medical University Chung-Ho Memorial Hospital | N/A |
| Completed | Oral Health Related Quality of Life in Head and Neck Cancer Survivors Within the First Year Following Treatmen NCT06730139 | Ain Shams University | — |
| Recruiting | Phase 2 Trial of Adaptive Radiotherapy Boost for HNSCC NCT06137274 | H. Lee Moffitt Cancer Center and Research Institute | Phase 2 |
| Recruiting | Evaluation of Radiobiological Effects in Skin Toxicities Head and Neck Cancer Patients With PBS Proton Therapy NCT06183268 | Covenant Health Cancer Center | N/A |
| Completed | Alcohol Cessation Among Head and Neck Cancer Survivors NCT05570851 | Northwell Health | N/A |
| Withdrawn | Role of Pharyngeal High Resolution Manometry and Impedance in Swallow Function of Head and Neck Cancer Patient NCT03372148 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | N/A |
| Recruiting | Feasibility of Early Swallowing and Speech Intervention for Head and Neck Cancer Patients Treated SURGically NCT06192771 | University Health Network, Toronto | N/A |
| Recruiting | NLit and Outcomes in HNC Survivor-Caregiver Dyads NCT07021885 | University of Kansas Medical Center | — |
| Recruiting | Simultaneous Integrated Boost in Carbon Ion Radiotherapy for Head and Neck Adenoid Cystic Carcinoma NCT05733910 | CNAO National Center of Oncological Hadrontherapy | N/A |
| Active Not Recruiting | A Study of Xevinapant With Cisplatin and Radiation Therapy After Surgery in People With Head and Neck Cancer NCT06145412 | Memorial Sloan Kettering Cancer Center | Phase 2 |
| Unknown | Safety and Superiority of Penicillamine in Radiosensitization of Recurrent Head and Neck Cancer NCT06103617 | Nanfang Hospital, Southern Medical University | Phase 2 |
| Recruiting | Prospective Validation of Adaptive Radiotherapy (ART) in Patients With Head and Neck Tumors NCT06214611 | University Hospital, Essen | N/A |
| Active Not Recruiting | Testing the Safety of Giving a Standard Dose of Radiation Over a Shorter Period of Time for Patients Who Had S NCT05540899 | American College of Radiology | Phase 1 |
| Recruiting | Evaluation of the Benefit of a New Surgical Procedure According to IDEAL Recommendations for ORL Cancer Patien NCT05757817 | Institut Claudius Regaud | N/A |
| Active Not Recruiting | Nutrition Throughout the Treatment Course - Expanding Care From Hospital to Home NCT05997329 | University of Oslo | N/A |
| Recruiting | Drug Screening Using Novel IMD in Salivary and Head and Neck Cancers NCT05553782 | Brigham and Women's Hospital | EARLY_Phase 1 |
| Completed | Maitland Mobilization and Scapular Stabilization Shoulder Dysfunction NCT06555913 | Cairo University | N/A |
| Terminated | Study of ALE.C04 in Patients With Head and Neck Cancer NCT06054477 | Alentis Therapeutics AG | Phase 1 / Phase 2 |
| Recruiting | Multi-Site Trial of Navigation vs Treatment as Usual to Improve Initiation of Timely Adjuvant Therapy NCT05793151 | Medical University of South Carolina | N/A |
| Enrolling By Invitation | Assessing Impact of Early Physiotherapy on Lymphatic Dysfunction in Head and Neck Cancer Survivorship NCT05937269 | The University of Texas Health Science Center, Houston | Phase 1 |
| Recruiting | Online Adaptive Radiotherapy Using a Novel Linear Accelerator (ETHOS) NCT06116019 | Charite University, Berlin, Germany | — |
| Terminated | Study of BDC-3042 as Single Agent and in Combination With Cemiplimab in Patients With Advanced Malignancies NCT06052852 | Bolt Biotherapeutics, Inc. | Phase 1 |
| Recruiting | Locally AblatiVe TherApy in OLigO-pRogressive SOlid TUmorS (VALOROUS) NCT06103669 | University of California, Davis | N/A |
| Not Yet Recruiting | Development of a Predictive Model for the Risk of Metastatic Disease in PPGLs, a Retrospective Cohort Study NCT04788927 | Rigshospitalet, Denmark | — |
| Completed | Tens and Rocabado Exercises on TMJ Dysfunction NCT05897983 | Cairo University | N/A |
| Recruiting | The RESCUE Study: Survival and Functional Outcomes Following Salvage Surgery for RESidual or reCurrent sqUamou NCT05808920 | Royal Marsden NHS Foundation Trust | — |
| Withdrawn | Virtual Reality Software to Reduce Stress in Cancer Patients NCT05263648 | University of Oklahoma | N/A |
| Recruiting | A Single-center Phase II Study to Investigate the Immune Maintenance Therapy Pattern in Patients With Locally NCT06208826 | Tianjin Medical University Cancer Institute and Hospital | Phase 2 |
| Active Not Recruiting | A Prospective Imaging Study of the Integrated TrueBeam-HyperSight CBCT System NCT05975619 | Varian, a Siemens Healthineers Company | N/A |
| Recruiting | Feasibility of CBCT-Guided Online Adaptive Radiotherapy (FASCINATE) NCT06691776 | The Netherlands Cancer Institute | N/A |
| Recruiting | Identification of Predictive Factors for the Response to Anti-Programmed Cell Death Protein 1 (PD1) Immunother NCT05328024 | Institut de cancérologie Strasbourg Europe | — |
| Recruiting | The SNAP Tool for Head and Neck Cancer Survivor-Caregiver Dyads NCT05811936 | Medical University of South Carolina | N/A |
| Unknown | A Study of SYH2051 Monotherapy in Advanced Solid Tumors or in Combination With Radiotherapy in Locally Advance NCT06011291 | CSPC ZhongQi Pharmaceutical Technology Co., Ltd. | Phase 1 |
| Unknown | Evaluation of the Implementation of Personalised Follow-up in Head and Neck Cancer NCT06170203 | Guy's and St Thomas' NHS Foundation Trust | — |
| Recruiting | High-resolution PET-CT Specimen Imaging for the Perioperative Visualization of Resection Margins NCT06835426 | Algemeen Ziekenhuis Maria Middelares | N/A |
| Completed | Pyrimethamine as an Inhibitor of NRF2 in HPV-unrelated Locally Advanced Head and Neck Squamous Cell Carcinoma NCT05678348 | Washington University School of Medicine | EARLY_Phase 1 |
| Withdrawn | Venlafaxine for the Prevention of Depression in Patients With Head and Neck Cancer NCT05724849 | Vanderbilt University Medical Center | Phase 2 |
| Completed | Low-Cost, Portable Flexible Nasopharyngoscope in Head & Neck Cancers in Low Resource Settings - Optimization P NCT04905134 | Duke University | N/A |
| Recruiting | A Study of ILB2109 and Toripalimab in Patients With Advanced Solid Malignancies NCT05955105 | Innolake Biopharm | Phase 1 / Phase 2 |
| Active Not Recruiting | A Study of Tislelizumab in Combination With Investigational Agents in Participants With Head and Neck Squamous NCT05909904 | BeiGene | Phase 2 |
| Withdrawn | Online Peri-operative Education Program for Patients Undergoing Major Head & Neck Surgery NCT05954676 | Washington University School of Medicine | N/A |
| Active Not Recruiting | Study Transplanting Bone Marrow Cells Into Salivary Glands to Treat Dry Mouth Caused by Radiation Therapy NCT05820711 | University of Wisconsin, Madison | Phase 1 |
| Recruiting | Head and Neck Early Relapse Detection Study (HERD) NCT05097625 | University College, London | — |
| Completed | On-treatment Adaptation of Head and Neck Cancer Dosimetry Plans Using Novel Cone-beam CT and AI-driven Softwar NCT05666193 | Varian, a Siemens Healthineers Company | N/A |
| Completed | Mulligan Technique on Shoulder Dysfunction NCT05915572 | Cairo University | N/A |
| Active Not Recruiting | A Screening Study to Collect Samples for TAA, HLA & HLA Loss of Heterozygosity in Patients With Metastatic Sol NCT05812027 | TScan Therapeutics, Inc. | — |
| Recruiting | A Clinical Study on Oncolytic Virus Injection (R130 OV) for the Treatment of Advanced Solid Tumors NCT05961111 | Shanghai Yunying Medical Technology | EARLY_Phase 1 |
| Completed | The Effect of 360° Virtual Reality Movies on Fear and Anxiety NCT06199050 | Maastricht Radiation Oncology | N/A |
| Recruiting | Developing Artificial Intelligence-based Algorism to Predict Side Effects and Symptoms From Chemotherapy NCT05937477 | Sehhoon Park | — |
| Recruiting | Skeletal Muscle Mass Changes on Images for Prediction of Prognosis After Exercise Training in HNSCC Patients NCT06666881 | Chang Gung Memorial Hospital | N/A |
| Not Yet Recruiting | MR-Linac for Head and Neck SBRT NCT04809792 | Sunnybrook Health Sciences Centre | N/A |
| Active Not Recruiting | A Study of SNS-101 (Anti VISTA) Monotherapy and in Combination With Cemiplimab in Patients With Advanced Solid NCT05864144 | Sensei Biotherapeutics, Inc. | Phase 1 / Phase 2 |
| Unknown | Adapting the Tumor Board Model for Mental Illness and Cancer NCT05837598 | Massachusetts General Hospital | N/A |
| Active Not Recruiting | ChatBot and Activity Monitoring in Patients Undergoing Chemoradiotherapy NCT05318027 | Abramson Cancer Center at Penn Medicine | Phase 2 |
| Recruiting | Preoperative Pembrolizumab and Chemotherapy in Resectable, Recurrent HNSCC NCT05726370 | Dana-Farber Cancer Institute | Phase 2 |
| Completed | Effect of Arginine and Glutamine on Radiation-induced Oral Mucositis: a Trible Blinded Randomized Controlled C NCT06764420 | Ain Shams University | N/A |
| Recruiting | Cognitive Outcomes After Brain Substructure-informed Radiation Planning in Pediatric Patients NCT05658731 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | N/A |
| Completed | Pilot Study of the eHealth Application "Cancer Patients Better Life Experience" (CAPABLE) - Italy NCT06161233 | Istituti Clinici Scientifici Maugeri SpA | N/A |
| Unknown | 3D Ultrasound, Specimen Examination by Surgeon, and MRI in Surgical Margin Assessment NCT05843032 | Rigshospitalet, Denmark | N/A |
| Completed | A Study of CDX-585 in Patients With Advanced Malignancies NCT05788484 | Celldex Therapeutics | Phase 1 |
| Recruiting | Arabic PRO Measures for Head and Neck Cancer Radiotherapy. NCT06662929 | King Saud University | — |
| Active Not Recruiting | Evaluating a Low-Cost Therapeutic Device in Managing Head and Neck Cancer Patients With Radiation-Related Tris NCT05671861 | University of California, San Francisco | N/A |
| Completed | Ii-HANC Improving Incurable Head and Neck Cancer Healthcare Experiences NCT05714436 | Sheffield Teaching Hospitals NHS Foundation Trust | — |
| Active Not Recruiting | Pilot Study of Imatinib Cetuximab Combo for H & N Cancer NCT05816785 | University of Wisconsin, Madison | EARLY_Phase 1 |
| Completed | Sarcopenia in Head and Neck Cancer Patients Treated with Curative Hadrontherapy NCT06207708 | CNAO National Center of Oncological Hadrontherapy | — |
| Completed | Feasibility of Internet Based Support (Carer eSupport) for Informal Caregivers of Patients With Head and Neck NCT05028452 | Uppsala University | N/A |
| Completed | Conventional Oxygen Therapy Versus Continuous Transnasal High Flow Oxygen Therapy for Head and Neck Diagnostic NCT05696288 | Centre Antoine Lacassagne | N/A |
| Active Not Recruiting | Evaluating Safety and Biomarkers Using DK210 (EGFR) for Locally Advanced or Metastatic EGFR+ Tumors NCT05704985 | DEKA Biosciences | Phase 1 |
| Unknown | A Human Versus Machine Comparison Study NCT06035653 | East and North Hertfordshire NHS Trust | — |
| Unknown | Prevention of Caries in Head and Neck Cancer Survivors Who Underwent Radiotherapy NCT06308796 | University of Milan | N/A |
| Completed | Pilot Study of Radiation-Induced Xerostomia Treatment With Allogeneic Mesenchymal Stromal Stem Cells NCT07431645 | Institute of Oncology Ljubljana | Phase 1 |
| Unknown | A Clinical Study on Oncolytic Virus Injection (R130) for the Treatment of Relapsed/Refractory Advanced Solid T NCT05886075 | Shanghai Yunying Medical Technology | EARLY_Phase 1 |
| Recruiting | Surface Monitoring Technology to Remove The Mask - Stage 1 NCT04266223 | University of Sydney | N/A |
| Recruiting | HRQoL in Patients With Solid Tumors Treated With Hadrontherapy NCT05947149 | CNAO National Center of Oncological Hadrontherapy | — |
| Unknown | A Clinical Study on Oncolytic Virus Injection (R130 OV) for the Treatment of Relapsed/Refractory Head and Neck NCT05830240 | Shanghai Yunying Medical Technology | EARLY_Phase 1 |
| Unknown | A Bidirectional Study in Exploring the Dynamic Changes of Plasma and Urine Metabolites of Head and Neck Cancer NCT05969262 | Nanfang Hospital, Southern Medical University | — |
| Completed | Evaluation of a Cone-beam CT Scanner for Image Guided Radiotherapy NCT05524454 | Varian, a Siemens Healthineers Company | N/A |
| Unknown | EVEREST-HN 1: EVolution of a patiEnt-REported Symptom-based Risk Stratification sySTem NCT05909020 | Royal Marsden NHS Foundation Trust | — |
| Recruiting | Dosing Study of Radiation Combined With Tislelizumab and Pamiparib in Patients With Previously Treated Head an NCT05526924 | University of Chicago | Phase 1 |
| Unknown | A Clinical Trial of KVA12123 Treatment Alone and in Combination With Pembrolizumab In Advanced Solid Tumors (V NCT05708950 | Kineta Inc. | Phase 1 / Phase 2 |
| Unknown | Phase II Study Exploring Five Fractions of Post-operative Radiation Therapy in Head and Neck Cancer NCT05648461 | All India Institute of Medical Sciences | N/A |
| Completed | Real-time Margin Assessment in Head and Neck Cancer NCT05499065 | University Medical Center Groningen | Phase 2 |
| Recruiting | Preclinical Research for Personalized TCR-T Therapy for Head and Neck Cancer NCT05697926 | Eye & ENT Hospital of Fudan University | — |
| Withdrawn | Oral AHR Antagonist in Combination With Nivolumab in Patients With PD-1 Resistant Metastatic or Recurrent Head NCT05472506 | Ikena Oncology | Phase 1 |
| Unknown | Effect of Nutritional Management on RIOM in Patients With Advanced Head and Neck Cancer NCT05721885 | Jing Yan | N/A |
| Recruiting | Intraoperative Ansa Cervicalis Nerve (ACN) Stimulation NCT05650710 | Vanderbilt University Medical Center | N/A |
| Recruiting | LEARN: Learning Environment for Artificial Intelligence in Radiotherapy New Technology NCT05184790 | University of Sydney | — |
| Completed | Total-Body FDG PET for Radiotherapy Response Assessment in Head and Neck Cancer NCT05625217 | University of California, Davis | N/A |
| Completed | Topical Anaesthesia in Cutaneous Head and Neck Surgery NCT06274905 | University Hospital Waterford | N/A |
| Recruiting | Building a Renewed ImaGe After Head & Neck Cancer Treatment (BRIGHT) Multi-Site RCT NCT05442957 | Medical University of South Carolina | N/A |
| Completed | Development of an Integrated Multi-channel Artificial Nose for Cancer Detection (UNos) NCT07419113 | Institute of Oncology Ljubljana | N/A |
| Active Not Recruiting | 3D Specimen Maps for RT Planning NCT05743569 | Vanderbilt University Medical Center | — |
| Completed | The Use of Photobiomodulation in the Management of Radiodermatitis in Head and Neck Cancer Patients NCT05557825 | University of Nove de Julho | — |
| Recruiting | A Single Arm, Prospective, Open Label, Multi Center, Phase Ib Study to Evaluate the Safety, Tolerability and I NCT05200650 | IntraGel Therapeutics | Phase 1 |
| Active Not Recruiting | Hypofractionated Preoperative Radiation for Head and Neck Cancers (HyPR-HN) NCT05538533 | Medical College of Wisconsin | N/A |
| Completed | Curcumin Gel On Radiation Induced Oral Mucositis NCT05982197 | University of Baghdad | N/A |
| Recruiting | Postoperative Management for HNSCC Based on Pathological Response of Induction Chemotherapy and Immunotherapy NCT05777824 | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | Phase 2 |
| Unknown | Surgical Margin Assessment by 3D Ultrasound NCT05740774 | Rigshospitalet, Denmark | N/A |
| Unknown | Evaluation of Vascular Toxicity of Immune Checkpoint Inhibitors in Patients Head and Neck or Lung Cancer NCT05655663 | Centre Henri Becquerel | N/A |
| Recruiting | Therapy-Associated Saliva and Taste Change Evaluation (TASTE) in Head & Neck Cancer Patients Undergoing Radiot NCT06444776 | Sonja Stieb, MD | — |
| Completed | A Phase 2 Open Label Study of BA3021 in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the H NCT05271604 | BioAtla, Inc. | Phase 2 |
| Completed | Carotid Ultrasound to Identify Head and Neck Cancer Survivors With High Cardiovascular Risk After Radiation Th NCT05490875 | Wake Forest University Health Sciences | — |
| Unknown | Prevention of Radiodermatitis in Breast and Head and Neck Cancer Patients in Cyprus NCT05588973 | Angelos Kassianos | N/A |
| Terminated | Oral AMXT 1501 Dicaprate in Combination With IV DFMO NCT05500508 | Aminex Therapeutics, Inc. | Phase 1 / Phase 2 |
| Completed | Effect of Triple Pre-rehabilitation on Radiotherapy for Head and Neck Cancer Patients NCT05594069 | Peking University | N/A |
| Unknown | Effectiveness Verification of Using Hydrogen Inhalation to Improve Fatigue, Pain and Quality of Life in Cancer NCT05728112 | Kaohsiung Medical University Chung-Ho Memorial Hospital | N/A |