NCT06274905

Topical Anaesthesia in Cutaneous Head and Neck Surgery

Topical Anaesthesia in Cutaneous Head and Neck Surgery: a Randomized Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 124 (actual)
• Sponsor: University Hospital Waterford · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

This study aims to assess if EMLA or ethyl chloride spray are effective in reducing the pain associated with local anaesthetic administration in cutaneous surgery of the head and neck compared to a placebo and control group through a randomized control trial study design.

Detailed description

Operations on cutaneous tissues of the head and neck are some of the most frequently performed types of operation performed. They can often successfully be performed using local anaesthetic (LA). However, tissues in this anatomic area are some of most sensitive tissues in the body to nociceptive pain. As such, local anaesthetic can be a distressing experience for patients in many ways. Unfortunately, it is also the most common anatomical site for cutaneous malignancies. The majority of these lesions are resected under local anaesthetic. However, one of the major disadvantages of local anaesthetic such as lidocaine is pain during administration. Several interventions have been used to reduce pain from needles and injections including ethylene chloride cryoanalgesic spray and topical anaesthetic agents including EMLA (lidocaine and prilocaine) and Ametop ointments. These have been extensively used in paediatric populations with great success to reduce pain during procedures requiring hypodermics such as cannulation. Several studies have trialled these interventions in adult populations across a variety of anatomical locations with variable results. The investigators aim to assess the efficacy of EMLA and ethyl chloride in mitigating nociceptive pain associated with local anaesthetic administration in patients undergoing cutaneous head and neck surgery.

Conditions

• Pain, Acute
• Head and Neck Cancer
• Cutaneous Tumor

Interventions

Type	Name	Description
DRUG	EMLA	EMLA cream
DRUG	Ethyl chloride	Ethyl chloride
DRUG	Aqueous cream BP	Aqueous cream

Timeline

• Start date: 2023-02-20
• Primary completion: 2023-07-07
• Completion: 2023-07-07
• First posted: 2024-02-23
• Last updated: 2024-02-23

Locations

1 site across 1 country: Ireland