NCT06691776

Feasibility of CBCT-Guided Online Adaptive Radiotherapy (FASCINATE)

FASCINATE: FeASibility of Cbct-guIded oNline Adaptive radioThErapy

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: The Netherlands Cancer Institute · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The accuracy of radiotherapy can be increased by correcting for geometric uncertainties and changes between radiotherapy fractions. These corrections are currently done with online adaptive treatment on a specialized linear accelerator (linac) for a small subset of patients. However, patients currently treated on a standard linac could also benefit from online adaptive radiotherapy. The objective is to determine the feasibility of online CBCT-guided adaptive radiation therapy on a standard Elekta linac.

Conditions

• Prostate Cancer
• Cervical Cancer
• Bladder Cancer
• Lung Cancer
• Head and Neck Cancer

Interventions

Type	Name	Description
DEVICE	online CBCT-guided adaptive radiation therapy using a new software	Patients are treated in the NKI with CBCT-guided online adaptive radiotherapy. While in the clinical workflow one planning CT is used to make the radiotherapy plan, this study treatment creates a new radiotherapy plan on the day of every treatment fraction. Instead of directly irradiating, the radiotherapy plan is adjusted to the anatomy of the day.

Timeline

• Start date: 2023-08-29
• Primary completion: 2028-10-01
• Completion: 2028-12-01
• First posted: 2024-11-15
• Last updated: 2025-08-01

Locations

1 site across 1 country: Netherlands