NCT06137274

Phase 2 Trial of Adaptive Radiotherapy Boost for HNSCC

Phase 2 Trial of Adaptive Radiotherapy Boost for Head and Neck Squamous Cell Carcinomas

• Status: Recruiting
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 35 (estimated)
• Sponsor: H. Lee Moffitt Cancer Center and Research Institute · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of the study is to determine if it is feasible to use magnetic resonance imaging (MRI) to adjust a portion of radiation therapy for patients with head and neck squamous cell carcinoma . The technique under study will be used to personalize the study treatment based on response, keeping all treatments within standard of care guidelines.

Conditions

• Squamous Cell Carcinoma
• Head and Neck Cancer

Interventions

Type	Name	Description
RADIATION	Intensity-modulated radiotherapy	All patients will be treated with intensity-modulated radiotherapy (IMRT) plans.
OTHER	Magnetic Resonance Guidance	All patients will undergo combined CT and/or MR simulation and will be treated with a sequential-boost technique.

Timeline

• Start date: 2023-12-14
• Primary completion: 2027-05-01
• Completion: 2027-05-01
• First posted: 2023-11-18
• Last updated: 2026-04-01

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study