| Withdrawn | Chemo-embolization for Head and Neck Cancer NCT04595981 | University of Alabama at Birmingham | Phase 2 |
| Not Yet Recruiting | A Trial of Locoregionally Advanced Squamous Cell Carcinoma of The Head and Neck NCT07346196 | University of Chicago | Phase 2 |
| Not Yet Recruiting | Omission of Postoperative Radiation in HPV-Associated Oropharyngeal Cancer Using ctHPVDNA Surveillance (OPERAT NCT07513389 | Medical University of South Carolina | Phase 2 |
| Not Yet Recruiting | Vitamin D Effects on Immune Microenvironment of Nonmelanoma Skin Cancer After Photodynamic Therapy (PDT) NCT07241585 | Case Comprehensive Cancer Center | N/A |
| Not Yet Recruiting | Cyclophosphamide and Etoposide as a Metronomic Therapy in Advanced Head and Neck Squamous Cell Cancer NCT07361133 | National Cancer Institute, Egypt | Phase 2 |
| Not Yet Recruiting | PDT For Induction Therapy For Head And Neck Cancer NCT07214987 | Massachusetts General Hospital | Phase 2 |
| Recruiting | Neoadjuvant Chemotherapy and Programmed Cell Death Protein 1(PD-1) Inhibition for Head and Neck Cancer Treatme NCT07209189 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Phase 2 |
| Recruiting | The Cancer Connected Access and Remote Expertise Beyond Walls Program to Provide In-Home Cancer Treatment and NCT07285044 | Mayo Clinic | Phase 2 |
| Not Yet Recruiting | Clinical Study Protocol for Cutaneous SCC for Immunocompromised Patients NCT06615635 | Alpha Tau Medical LTD. | N/A |
| Recruiting | Patient Preference for Subcutaneous vs. Intravenous Immune Therapy NCT07223424 | Diwakar Davar | Phase 2 |
| Recruiting | Screening for Anal Cancer in Men Who Have Sex With Men Using Pre-Exposure Prophylaxis NCT07029152 | Universitair Ziekenhuis Brussel | N/A |
| Recruiting | Defining TRPV4 Contribution of Schwann Cells to Oral Cancer Pain NCT07095608 | New York University | N/A |
| Recruiting | Prospective Data Collection Initiative on Thoracic Malignancies NCT06996249 | Dutch Society of Physicians for Pulmonology and Tuberculosis | — |
| Recruiting | Electrochemotherapy (ECT) in Patients With Primary Visceral Tumors and/or Secondary Visceral Localizations, of NCT06753136 | Istituto Oncologico Veneto IRCCS | N/A |
| Not Yet Recruiting | Drug Screening of Cutaneous Lesions of Squamous Cell Carcinoma NCT06782399 | Oliver Jonas | EARLY_Phase 1 |
| Recruiting | Toripalimab With Chemotherapy for Sinus Cancer NCT06940180 | Glenn J. Hanna | Phase 2 |
| Recruiting | Treating Basal and Squamous Cell Carcinomas With Fractional Laser and Tirbanibulin Ointment NCT07010692 | Bruce Robinson, MD | Phase 1 / Phase 2 |
| Withdrawn | Phase II Study of Atezolizumab and Tiragolumab With ctDNA for HPV-positive SCC NCT06762808 | M.D. Anderson Cancer Center | Phase 2 |
| Recruiting | Intratumoral Lidocaine Injection Before Oropharyngeal Cancer Surgery NCT06747390 | Ryan Carey | Phase 1 |
| Recruiting | Impact of COL7A1 Gene Therapy on SCC Recurrence in RDEB Skin NCT06731933 | Stanford University | Phase 2 |
| Not Yet Recruiting | Neoadjuvant DaRT for Locally Advanced Oral Cavity SCC NCT05065346 | Alpha Tau Medical LTD. | N/A |
| Recruiting | Use of SPY Imaging System to Minimize Fistulas After Hypopharyngeal Reconstruction NCT06831149 | Matthew Spector | Phase 2 |
| Recruiting | Raman Spectroscopy and Skin Cancer NCT06384924 | Renee Farrell | — |
| Not Yet Recruiting | CHG0521 Oral Coating in Patients with Solid Tissue Tumor/Recurrent/Metastatic TSCC NCT06609070 | Guangzhou University of Traditional Chinese Medicine | N/A |
| Recruiting | A Study of VET3-TGI in Patients With Solid Tumors NCT06444815 | KaliVir Immunotherapeutics | Phase 1 |
| Not Yet Recruiting | Patient Perspectives in Squamous Cell Carcinoma Clinical Trials NCT05929547 | Power Life Sciences Inc. | — |
| Not Yet Recruiting | Early Detection of Esophageal Squamous Cancer With the Capsule Sponge Device NCT06418516 | Centre of Postgraduate Medical Education | N/A |
| Not Yet Recruiting | Hyperthermia Enhanced Re-irradiation of Loco-regional Recurrent Tumors NCT04889742 | Charite University, Berlin, Germany | Phase 2 |
| Recruiting | BAI-BACE for Advanced Lung Squamous Cell Carcinoma NCT06377735 | Sun Yat-sen University | N/A |
| Recruiting | Study of the Relationship Between Clinical, Imaging and Biological Data in Patients With Squamous Cell Carcino NCT06450080 | Centre Hospitalier Universitaire, Amiens | N/A |
| Recruiting | A Phase Ib/II Study of an Anti-HER3 Antibody, HMBD-001, With Cetuximab +/- Docetaxel in Advanced Squamous Cell NCT05910827 | Hummingbird Bioscience | Phase 1 / Phase 2 |
| Recruiting | Phase 2 Trial of Adaptive Radiotherapy Boost for HNSCC NCT06137274 | H. Lee Moffitt Cancer Center and Research Institute | Phase 2 |
| Recruiting | Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Meta NCT06047379 | Neonc Technologies, Inc. | Phase 1 / Phase 2 |
| Active Not Recruiting | A Study of Pembrolizumab (+) Berahyaluronidase Alfa (MK-3475A) (Pembrolizumab Formulated With Berahyaluronidas NCT06041802 | Merck Sharp & Dohme LLC | Phase 2 |
| Unknown | Buccal Cancer Resection Ultrasound Guided NCT05852665 | UMC Utrecht | N/A |
| Withdrawn | Cemiplimab/Peg-Interferon-α in Advanced CSCC NCT05729139 | Baptist Health South Florida | Phase 1 |
| Active Not Recruiting | Neo-adjuvant Treatment for Squamous Cell Carcinoma Using Direct Tumor Injection With RP1. NCT05858229 | Sherrif Ibrahim | Phase 1 / Phase 2 |
| Unknown | Topical Ascorbic Acid for Treatment of Squamous Cell Skin Cancer NCT05932511 | Center for Biomedical Research, Inc. | EARLY_Phase 1 |
| Recruiting | Phase 2 Trial of Neoadjuvant and Adjuvant Tiragolumab Plus Atezolizumab in Patients With Newly Diagnosed PD-L1 NCT05681039 | M.D. Anderson Cancer Center | Phase 2 |
| Recruiting | INTEGRATIVE "MULTI-OMICS" AND FUNCTIONAL PLATFORM FOR THE COMPLETE DIAGNOSTIC CHARACTERIZATION OF TUMORS: THE NCT07403630 | Azienda Ospedaliero-Universitaria di Parma | N/A |
| Unknown | 3D Ultrasound, Specimen Examination by Surgeon, and MRI in Surgical Margin Assessment NCT05843032 | Rigshospitalet, Denmark | N/A |
| Completed | Mentored Community Gardening for Individuals With Skin Cancer NCT05648604 | University of Arizona | N/A |
| Unknown | Surgical Margin Assessment by 3D Ultrasound NCT05740774 | Rigshospitalet, Denmark | N/A |
| Recruiting | Survival and Prognostic Factors of Squamous Cell Carcinoma of the Nasal Vestibule NCT05693116 | Istituto Clinico Humanitas | — |
| Active Not Recruiting | A Study of Radiation Therapy and Cemiplimab for People With Skin Cancer NCT05574101 | Memorial Sloan Kettering Cancer Center | Phase 2 |
| Withdrawn | Phase 2 Study of Neoadjuvant SAR444245 Plus Cemiplimab in HPV Related Oropharynx Squamous Cell Carcinoma NCT05535023 | M.D. Anderson Cancer Center | Phase 2 |
| Unknown | Atezolizumab Immunotherapy, in Immunotherapy Naive Patients With Urinary Tract Squamous Cell Carcinoma (UTSCC) NCT05038657 | University Hospital Southampton NHS Foundation Trust | Phase 2 |
| Active Not Recruiting | Impact of Human Papillomavirus (HPV) Vaccination on Burden of Disease in Patients with Actinic Keratosis NCT05202860 | Merete Haedersdal | Phase 2 |
| Unknown | Clinical vAlidation of a MobilE appLication ("ProRodinki") in the Assessment of the maLignant skIn neoplAsms NCT05402046 | MelanomaPRO, Russia | N/A |
| Unknown | Serum Exosomal miRNA Predicting the Therapeutic Efficiency in Lung Squamous Carcinoma NCT05854030 | Tianjin Medical University Cancer Institute and Hospital | — |
| Completed | DERM US and EU Validation Study NCT05126173 | Skin Analytics Limited | — |
| Completed | A Multicenter Clinical Trial of Sputum DNA Testing for Lung Cancer in China NCT05337163 | Creative Biosciences (Guangzhou) Co., Ltd. | — |
| Active Not Recruiting | Analyzing Clinical Outcomes and Genomic Data of American Indian Patient Population NCT05863052 | University of Oklahoma | — |
| Completed | A Retrospective Analysis to Evaluate Long Term Outcomes of SCC Patients Previously Treated With Alpha DaRT NCT05125354 | Alpha Tau Medical LTD. | — |
| Unknown | Ex-vivo Examination of Excisions of Skin Tumors by Confocal Optical Coherence Tomography (LC-OCT) With Integra NCT05340543 | Ramsay Générale de Santé | — |
| Active Not Recruiting | Testing the Addition of the Anti-cancer Viral Therapy Telomelysin™ to Chemoradiation for Patients With Advance NCT04391049 | NRG Oncology | Phase 1 |
| Recruiting | Immunotherapy With Chemotherapy and Chemoradiation for Advanced Squamous Cancer of Nasal Cavity / Paranasal Si NCT05027633 | M.D. Anderson Cancer Center | Phase 2 |
| Active Not Recruiting | Needs and Preferences of Patients With Head-neck Cutaneous SCC NCT06046625 | Maastricht University Medical Center | — |
| Recruiting | Sentinel Lymph Node Biopsy for Cutaneous Squamous Cell Carcinoma of the Head and Neck NCT05108090 | Indiana University | N/A |
| Terminated | Study of PF-07263689 in Participants With Selected Advanced Solid Tumors NCT05061537 | Pfizer | Phase 1 |
| Unknown | Spectroscopic Analysis of Tongue Tumor Samples. NCT05104619 | Centre Hospitalier Universitaire, Amiens | — |
| Recruiting | Study of Afatinib in Advanced Cutaneous Squamous Cell Carcinoma NCT05070403 | H. Lee Moffitt Cancer Center and Research Institute | Phase 2 |
| Active Not Recruiting | Comparing Two Surveillance Approaches for People Who Have Received Treatment for HPV-associated Head and Neck NCT05048459 | Memorial Sloan Kettering Cancer Center | N/A |
| Unknown | Study of the Association Between Tumor Microenvironment Macrophages and Treatment Response in Squamous Cell Ca NCT05019235 | Fondation Hôpital Saint-Joseph | — |
| Completed | Second-line Cabozantinib and Atezolizumab in Patients With Recurrent or Metastatic Esophageal Squamous Cell Ca NCT05007613 | National Taiwan University Hospital | Phase 2 |
| Completed | Incidence of Melanoma and Non-melanoma Skin Cancer in People With Vitiligo NCT04969419 | Momentum Data | — |
| Active Not Recruiting | Neoadjuvant Study of PD-1 Inhibitor Pembrolizumab in PD-1 Naive Cutaneous Squamous Cell Carcinoma (cSCC) NCT04808999 | Diwakar Davar | Phase 2 |
| Active Not Recruiting | Surgical Treatment of Stage T3 Squamous Cell Carcinomas of the Scalp NCT05987579 | Maastricht University Medical Center | — |
| Unknown | Combination 5-FU / Calcipotriene Cream for SCCIS/SCC NCT04839731 | Carilion Clinic | EARLY_Phase 1 |
| Completed | Rigosertib for RDEB-SCC NCT03786237 | Prof. Johann Bauer | Phase 1 / Phase 2 |
| Unknown | T1 Squamous Cell Carcinomas of the Lip NCT05610293 | Maastricht University Medical Center | — |
| Unknown | Heat Shock Protein (HSP) 70 to Quantify and Characterize Circulating Tumor Cells NCT04628806 | Charite University, Berlin, Germany | — |
| Completed | Effects of (Licochalcone A) and Paclitaxel on Human Oral Squamous Cell Carcinoma Cell Line NCT03292822 | Cairo University | Phase 1 |
| Suspended | DNX-2440 for Resectable Colorectal Liver Metastasis NCT04714983 | DNAtrix, Inc. | Phase 1 |
| Unknown | Clinical Study of Camrelizumab in Combination With Neoadjuvant Chemotherapy for Operable Locally Advanced Head NCT04922450 | Hunan Cancer Hospital | Phase 2 |
| Terminated | Clinical Study Evaluating the Proper Surgical Safety Margin for Early Stage Oral Tongue Cancers NCT04738786 | Samsung Medical Center | N/A |
| Terminated | Imvamune Vaccine for the Treatment of Non-melanoma Skin Cancer NCT04410874 | Ivan Litvinov | Phase 1 / Phase 2 |
| Completed | Study of Circulating Tumor DNA (ctDNA) Kinetics in Immuno-oncology (IO-KIN) NCT04606940 | University Health Network, Toronto | — |
| Terminated | A Study to Evaluate the Safety and Pharmacokinetics of OC-001 in Patients With Locally Advanced or Metastatic NCT04260802 | Ocellaris Pharma, Inc. | Phase 1 / Phase 2 |
| Recruiting | A Clinical Study of Intratumoral MVR-T3011 (T3011) Given as a Single Agent and in Combination With Intravenous NCT04370587 | ImmVira Pharma Co. Ltd | Phase 1 / Phase 2 |
| Unknown | A Study of SBRT for Squamous Cell Carcinoma of the Head and Neck NCT04435938 | McMaster University | Phase 2 |
| Terminated | Optimized Diffusion-Weighted Imaging for the Evaluation of Post-Treatment Squamous Cell Carcinoma in the Neck: NCT04685798 | Washington University School of Medicine | N/A |
| Unknown | A Biomarker-implemented Clinical Study Evaluating Mutations in MET and TP53 in a Population of Treatment-refra NCT04533321 | National University Hospital, Singapore | Phase 2 |
| Terminated | A Study of NM21-1480 in Adult Patients With Advanced Solid Tumors NCT04442126 | Numab Therapeutics AG | Phase 1 / Phase 2 |
| Enrolling By Invitation | HRQoL Keratinocyte Carcinomas NCT04814953 | University Hospital, Ghent | — |
| Unknown | Skin Tumor Biomarkers by Mass Spectrometry Imaging NCT06227416 | Bispebjerg Hospital | N/A |
| Completed | Prognostic Immune Biomarkers in HNSCC NCT05941676 | University Hospital Ostrava | — |
| Unknown | Dose Optimized BNCT for Head and Neck Cancer NCT05883007 | Southern Tohoku BNCT Research Center | Phase 1 |
| Completed | Epigenetic Changes in Head and Neck Cancer NCT04260074 | Aalborg University Hospital | — |
| Active Not Recruiting | 1922GCCC: Pembro and Bavituximab for Squamous Cell Carcinoma of Head and Neck NCT04150900 | University of Maryland, Baltimore | Phase 2 |
| Terminated | Topical Remetinostat Gel as Neoadjuvant Therapy in Patients With Squamous Cell Carcinoma (SCC) NCT03875859 | Kavita Sarin | Phase 2 |
| Active Not Recruiting | De-intensified Radiation Therapy With Chemotherapy (Cisplatin) or Immunotherapy (Nivolumab) in Treating Patien NCT03952585 | National Cancer Institute (NCI) | Phase 2 / Phase 3 |
| Withdrawn | A Non-Interventional Pilot Study to Explore the Skin Microbes in Skin Cancer NCT04099446 | ProgenaBiome | — |
| Recruiting | Early Diagnosis of Upper Digestive Tract Disease NCT04475952 | Imperial College London | — |
| Completed | De-Escalation Therapy for Human Papillomavirus Negative Disease NCT03944915 | University of Chicago | Phase 2 |
| Completed | IRX-2 Regimen and Durvalumab, for Incurable H&N Squamous Cell Carcinoma NCT03381183 | H. Lee Moffitt Cancer Center and Research Institute | Phase 1 |
| Unknown | A Window of Opportunity Trial of Intratumoral Injection of Copaxone® in Patients With Percutaneously Accessibl NCT03982212 | University of Kansas Medical Center | Phase 1 |
| Terminated | Use of Electrical Impedance Spectroscopy (EIS) for Early Diagnosis of Skin Damage NCT04688749 | Aristotle University Of Thessaloniki | — |
| Unknown | Teripalimab Plus Chemotherapy in Local Advanced Esophageal Cancer NCT03985670 | Henan Cancer Hospital | Phase 2 |
| Terminated | Long-term, Non-interventional, Observational Study Following Treatment With Fate Therapeutics FT500 Cellular I NCT04106167 | Fate Therapeutics | — |
| Completed | Cetuximab in Head and Neck Cancer Patients NCT03769311 | University of Wisconsin, Madison | Phase 2 |
| Active Not Recruiting | Nivolumab and BMS986205 in Treating Patients With Stage II-IV Squamous Cell Cancer of the Head and Neck NCT03854032 | Thomas Jefferson University | Phase 2 |
| Unknown | The PIONEER Initiative: Precision Insights On N-of-1 Ex Vivo Effectiveness Research Based on Individual Tumor NCT03896958 | SpeciCare | — |
| Terminated | Concurrent Nab-P/Carboplatin and Thoracic Radiotherapy in Squamous Cell Lung Cancer NCT03802058 | Wuhan University | Phase 2 |
| Recruiting | Preoperative Immunotherapy in Patients With Squamous Cell Carcinoma of the Head and Neck NCT03708224 | Alain Algazi | Phase 2 |
| Completed | Nal-iri/lv5-fu Versus Paclitaxel as Second Line Therapy in Patients With Metastatic Oesophageal Squamous Cell NCT03719924 | Federation Francophone de Cancerologie Digestive | Phase 2 |
| Completed | FT500 as Monotherapy and in Combination With Immune Checkpoint Inhibitors in Subjects With Advanced Solid Tumo NCT03841110 | Fate Therapeutics | Phase 1 |
| Completed | IRX-2 Regimen Combined With Nivolumab in Recurrent/Metastatic Solid Tumors NCT03758781 | H. Lee Moffitt Cancer Center and Research Institute | Phase 1 |
| Completed | Surgery Plus Intraoperative Radiotherapy as Treatment for Squamous Cell Carcinoma Over Pilonidal Disease. NCT04201002 | Hospital Provincial de Castellon | — |
| Unknown | Prognostic Value of Tumor Thickness of Buccal Mucosa Squamous Cell Carcinoma on the Incidence of Nodal Metasta NCT03837613 | Mohamed Ghorab | — |
| Unknown | PET Imaging-guided Chemoradiotherapy in Esophageal Squamous Cell Carcinoma NCT03791905 | Mian XI | Phase 2 |
| Completed | Study of TVEC in Patients With Cutaneous Squamous Cell Cancer NCT03714828 | University of Arizona | Phase 2 |
| Completed | M6620 Plus Standard Treatment in Oesophageal and Other Cancer NCT03641547 | University of Oxford | Phase 1 |
| Withdrawn | Afatinib and Nivolumab as Treatment for Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck NCT03652233 | Vanderbilt-Ingram Cancer Center | Phase 1 |
| Unknown | Study Assessing the Safety and Performance of Smart Matrix® NCT03742726 | Smart Matrix Limited | N/A |
| Active Not Recruiting | TORS De-Intensification Protocol Version 2.0: Dose and Volume Reduction in the Neck NCT03729518 | Abramson Cancer Center at Penn Medicine | N/A |
| Unknown | Study of Anlotinib Plus Chemotherapy as the First-line Treatment in Patients With Advanced NSCLC NCT03636685 | Chinese Academy of Medical Sciences | Phase 1 / Phase 2 |
| Active Not Recruiting | EACH: Evaluating Avelumab in Combination With Cetuximab in Head and Neck Cancer NCT03494322 | University College, London | Phase 2 |
| Recruiting | IMRT and Primary Transoral Surgery in the Treatment of Squamous Cell Carcinomas NCT04224389 | Gustave Roussy, Cancer Campus, Grand Paris | — |
| Active Not Recruiting | Quercetin Chemoprevention for Squamous Cell Carcinoma in Patients With Fanconi Anemia NCT03476330 | Children's Hospital Medical Center, Cincinnati | Phase 2 |
| Completed | PET-MRI Assessment of Early Tumor Response to Predict Outcomes of HPV-Positive Oropharynx Cancer Patients NCT03342378 | University of Wisconsin, Madison | — |
| Completed | T-VEC in Non-melanoma Skin Cancer NCT03458117 | University of Zurich | Phase 1 |
| Unknown | Afatinib Plus Chemotherapy Against Esophageal or Lung Squamous Cell Carcinoma NCT03486509 | Fujian Cancer Hospital | Phase 2 |
| Terminated | QUILT-3.090: NANT Squamous Cell Carcinoma (SCC) Vaccine: Subjects With SCC Who Have Progressed NCT03387111 | ImmunityBio, Inc. | Phase 1 / Phase 2 |
| Terminated | Metabolomic and BH3 Profiling of Esophageal Cancers: Identification of Novel Assessment Methods of Treatment R NCT03223662 | National Cancer Institute (NCI) | Phase 2 |
| Completed | Study of Pembrolizumab (MK-3475) in Adults With Recurrent/Metastatic Cutaneous Squamous Cell Carcinoma (cSCC) NCT03284424 | Merck Sharp & Dohme LLC | Phase 2 |
| Completed | Nivolumab and Tumor Infiltrating Lymphocytes (TIL) in Advanced Non-Small Cell Lung Cancer NCT03215810 | H. Lee Moffitt Cancer Center and Research Institute | Phase 1 |
| Unknown | PEN-866 in Patients With Advanced Solid Malignancies NCT03221400 | Tarveda Therapeutics | Phase 1 / Phase 2 |
| Completed | Nivolumab (Opdivo®) Plus ABI-009 (Nab-rapamycin) for Advanced Sarcoma and Certain Cancers NCT03190174 | Sarcoma Oncology Research Center, LLC | Phase 1 / Phase 2 |
| Terminated | PEmbrolizumab Combined With Chemoradiotherapy in Squamous Cell Carcinoma of the Head and Neck NCT02819752 | Royal Marsden NHS Foundation Trust | Phase 1 |
| Unknown | Neoadjuvant Chemotherapy Followed by Preoperative Chemoradiation in Resectable Squamous-cell Esophageal Cancer NCT03579004 | Mona Frolova | Phase 2 |
| Terminated | A Trial to Compare the Incidence of Squamous Cell Carcinoma (SCC) and Other Skin Neoplasia on Skin Areas Treat NCT03115476 | LEO Pharma | Phase 3 |
| Unknown | Molecular Characterization of Cutaneous Tumors NCT03092830 | Rabin Medical Center | — |
| Completed | Alpha Radiation Emitters Device for the Treatment of Squamous Cell Carcinoma NCT03015883 | Alpha Tau Medical LTD. | N/A |
| Completed | A Phase 1/2 Safety Study of Intratumorally Dosed INT230-6 NCT03058289 | Intensity Therapeutics, Inc. | Phase 1 / Phase 2 |
| Unknown | Photodynamic Therapy for Treatment of Cutaneous Squamous Cell Carcinoma in Situ NCT03025724 | Rhode Island Hospital | N/A |
| Unknown | Quantitative Optical Sensor Findings in Head & Neck Squamous Cell Carcinoma NCT02943044 | Zenalux Biomedical, Inc. | — |
| Completed | Isolating and Testing Circulating Tumor DNA and Soluble Immune Markers During the Course of Treatment for Lung NCT02410603 | Mayo Clinic | — |
| Completed | Tele-dermatology of Skin Cancer in a Cohort of Local Health Authority Employees in the Province of Bergamo NCT02902822 | Centro Studi Gised | N/A |
| Terminated | Trial of Intratumoral Injections of TTI-621 in Subjects With Relapsed and Refractory Solid Tumors and Mycosis NCT02890368 | Pfizer | Phase 1 |
| Withdrawn | Cetuximab, Cisplatin and BYL719 for HPV-Associated Oropharyngeal Squamous Cell Carcinoma NCT02298595 | Julie E. Bauman, MD, MPH | Phase 1 / Phase 2 |
| Unknown | Role of Neo-adjuvant Chemotherapy in Tongue Preservation in Locally Advanced Squamous Cell Carcinoma of Oral T NCT02985255 | HealthCare Global Enterprise Ltd. | Phase 2 |
| Completed | Postoperative Concurrent Chemoradiotherapy With Docetaxel for High-Risk Squamous Cell Carcinoma of Head and Ne NCT02776137 | Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University | Phase 2 |
| Completed | Strategies to Promote Skin Health NCT03237013 | San Diego State University | N/A |
| Completed | Role of Myostatin, Activin A and Follistatin Cachexia of ENT Cancers NCT03162042 | University Hospital, Clermont-Ferrand | — |
| Completed | Pembrolizumab in Combination With CRT for LA-SCCHN NCT02586207 | Sanford Health | Phase 1 |
| Completed | Using MC1R Genotype to Impact Melanoma Risk Behavior NCT03509467 | H. Lee Moffitt Cancer Center and Research Institute | N/A |
| Completed | Utility of the Skin Cancer Quality of Life Impact Tool NCT02580916 | Oxford University Hospitals NHS Trust | N/A |
| Completed | The Potential for Metformin to Improve Tumor Oxygenation in Locally Advanced Cervix Cancer: A Phase II Randomi NCT02394652 | University Health Network, Toronto | Phase 2 |
| Completed | EktoTherix™ Regenerative Tissue Scaffold for Repair of Surgical Excision Wounds NCT02409628 | Neotherix Limited | N/A |
| Terminated | Identification of Prognostic Biomarkers for Progression of Invasive Squamous Cell Carcinoma NCT02549638 | Mayo Clinic | — |
| Terminated | Safety Study of SEA-CD40 in Cancer Patients NCT02376699 | Seagen Inc. | Phase 1 |
| Completed | Esophagectomy for Patients With Esophageal Cancer and Cervical Lymph Node Metastases NCT02426879 | UMC Utrecht | N/A |
| Unknown | Skin Cancer Screening Education Study NCT02352428 | Association of Dermatological Prevention, Germany | N/A |
| Completed | Study of Chemotherapy Combination With Autologous Cytokine-Induced Killer Cell Immunotherapy to Treat Lung Can NCT01631357 | Tianjin Medical University Cancer Institute and Hospital | Phase 2 / Phase 3 |
| Recruiting | T Cell Receptor Immunotherapy for Patients With Metastatic Non-Small Cell Lung Cancer NCT02133196 | National Cancer Institute (NCI) | Phase 2 |
| Terminated | Selinexor Treatment of Advanced Relapsed/Refractory Squamous Cell Carcinomas NCT02213133 | Karyopharm Therapeutics Inc | Phase 2 |
| Completed | A Study to Isolate and Test Circulating Tumor Cells Using the ClearCell® FX EP+ System NCT02370303 | Mayo Clinic | — |
| Terminated | Safety, Tolerability and Performance of SmartMatrix Dermal Replacement Scaffold NCT02059252 | Smart Matrix Limited | Phase 1 / Phase 2 |
| Suspended | Evaluation of the Role of Vibrational Spectroscopy in the Assessment of Vulval Disease NCT02223975 | Gloucestershire Hospitals NHS Foundation Trust | — |
| Completed | Safety and Efficacy Study of Abraxane in Combination With Carboplatin to Treat Advanced NSCL Cancer in the Eld NCT02151149 | Celgene | Phase 4 |
| Completed | A Study of DKN-01 in Combination With Paclitaxel or Pembrolizumab NCT02013154 | Leap Therapeutics, Inc. | Phase 1 |
| Completed | Electronic Skin Surface Brachytherapy for Cutaneous Basal Cell and Squamous Cell Carcinoma NCT02131805 | Memorial Sloan Kettering Cancer Center | N/A |
| Completed | Aggressive Squamous Cell Carcinoma in Organ Transplant Recipients NCT02095912 | University of Zurich | — |
| Recruiting | Radiotherapy With Cisplatin vs. Docetaxel-cetuximab in HNSCC: ERCC1 Biomarker Enrichment and Interaction Desig NCT02128906 | Christopher Wilke | Phase 2 |
| Completed | Nedaplatin (Jiebaishu®) Combined With Docetaxel for Advanced Lung Squamous Cell Carcinoma NCT02088515 | Jiangsu Simcere Pharmaceutical Co., Ltd. | Phase 4 |
| Unknown | Metastases of Cutaneous Squamous Cell Carcinoma in Organ Transplant Recipients. The "SCOPE-ITSCC Metastases St NCT01976468 | University of Zurich | — |
| Completed | Nanocytology Test to Evaluate Skin Cancer in High Risk Patients NCT01905891 | Northwestern University | N/A |
| Terminated | Cetuximab + Taxotere With Low Dose Fractionated Radiation for Head and Neck Carcinoma NCT01794845 | University of Miami | Phase 2 |
| Completed | Reflectance Confocal Microscopy of Wounds During Moh's Surgery: Feasibility Testing of a Mosaicing Algorithm f NCT01872130 | Memorial Sloan Kettering Cancer Center | — |
| Completed | Radiation and Cetuximab Plus Intratumoral EGFR Antisense DNA in Locally Advanced Head and Neck Squamous Cell C NCT01592721 | The University of Texas Health Science Center at San Antonio | Phase 1 / Phase 2 |
| Unknown | CETUXIMAB Given for 3 Weeks as Neoadjuvant Treatment in Locally Advanced Tongue Cancer ; A NEW PARADIGM OF TRE NCT01760811 | Rabin Medical Center | Phase 1 / Phase 2 |
| Terminated | Single-center Investigator Initiated Pilot Study Investigating the Tumor Response of Squamous Cell Carcinoma L NCT01666431 | University of Zurich | Phase 2 |
| Completed | Does Cryofixation of Skin Specimens Affect Quality of Subsequent Formalin Fixed Paraffin Embedded H and E Hist NCT01540695 | Abramson Cancer Center at Penn Medicine | — |
| Completed | Eversion in Dermatologic Surgery: Is Cosmetic Appearance Improved? NCT01770002 | University of California, Davis | N/A |
| Terminated | Optical Imaging of Head and Neck Cancer NCT01456143 | Sharmila Anandasabapathy, MD | N/A |
| Completed | Study of AXL1717 Compared to Docetaxel to Treat Squamous Cell Carcinoma or Adenocarcinoma of the Lung NCT01561456 | Axelar AB | Phase 2 |
| Terminated | Phase 0 of 18F FPM Using PET/CT in Patients With a Variety of Malignancies NCT01755650 | Peter MacCallum Cancer Centre, Australia | EARLY_Phase 1 |
| Completed | Set-back Suture Versus Traditional Vertical Mattress Suture NCT01773447 | University of California, Davis | N/A |
| Unknown | Intensity-Modulated or Proton Radiation Therapy for Sinonasal Malignancy NCT01586767 | Massachusetts General Hospital | N/A |
| Completed | Absorbable Suture Versus Tissue Glue to Repair Defects Following Mohs Surgery NCT01298167 | Yale University | N/A |
| Terminated | Metformin Plus Paclitaxel for Metastatic or Recurrent Head and Neck Cancer NCT01333852 | Lucas Vieira dos Santos | Phase 2 |
| Terminated | Study of Safety and Efficacy of Talimogene Laherparepvec With Cisplatin and Radiotherapy for Treatment of Loca NCT01161498 | BioVex Limited | Phase 3 |
| Unknown | Comparison of Translocator Protein Expression and Binding Activity in Normal Tissue Versus Non Melanotic Malig NCT01265472 | Rambam Health Care Campus | — |
| Completed | A Feasibility Study On Continuous Adaptive [18f]Fdg-Pet-Guided Radiotherapy For Head and Neck Cancer NCT01208883 | University Hospital, Ghent | Phase 1 |
| Unknown | Nimotuzumab in Combination With Chemoradiation for Local Advanced Esophageal Squamous Cell Carcinoma NCT01232374 | Biotech Pharmaceutical Co., Ltd. | Phase 2 |
| Withdrawn | School Response to Families Who Have Children With Cancer NCT01148082 | Stanford University | — |
| Completed | Trial Comparing Two Protocols of re Irradiation in an Irradiated Area for Carcinoma of the Upper Aerodigestive NCT01211938 | Gustave Roussy, Cancer Campus, Grand Paris | Phase 2 / Phase 3 |
| Completed | Impact of Positron Emission Tomography (PET) Imaging in Women With Locally Advanced Cervical Cancer (PET LACE NCT00895349 | Ontario Clinical Oncology Group (OCOG) | N/A |
| Completed | Observational Study of Incidence Rates of Esophageal Cancer in Women Taking Medications for the Prevention or NCT01077817 | Organon and Co | — |
| Completed | Cetuximab and Lenalidomide in Head and Neck NCT01133665 | University of Chicago | Phase 2 |
| Completed | A Phase 1 Study in Participants With Advanced Cancer NCT01115790 | Eli Lilly and Company | Phase 1 |
| Completed | Chemoradiation and Panitumumab for Esophageal Cancer NCT01077999 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Phase 2 |
| Completed | Neoadjuvant Therapy for Esophageal Cancer and Cardiopulmonary Physiology NCT03462524 | St. James's Hospital, Ireland | — |
| Terminated | Temsirolimus (Torisel®) and Erlotinib (Tarceva®) in Platinum-Refractory/Ineligible, Advanced, Squamous Cell Ca NCT01009203 | New Mexico Cancer Research Alliance | Phase 2 |
| Completed | Observational Study of Swallowing Function After Treatment of Advanced Laryngeal Cancer NCT01089803 | University of Minnesota | — |
| Completed | Electronic Brachytherapy for the Treatment of NMSC NCT01016899 | Xoft, Inc. | — |
| Completed | Testosterone for Treating Cachexia in Patients With Squamous Cell Carcinoma NCT00878995 | The University of Texas Medical Branch, Galveston | Phase 1 |
| Completed | Videoscopic Versus Open Inguinal Lymphadenectomy for Cancer NCT01526486 | Emory University | N/A |
| Withdrawn | T-cell Based Immunotherapy for Head and Neck Cancer NCT00937300 | Inge Marie Svane | Phase 1 |
| Completed | Human Papillomavirus on Oral Tissue, Saliva and Serum NCT01043328 | UPECLIN HC FM Botucatu Unesp | — |
| Completed | An Exploratory, Open Label, Multi-Center, Non-Randomized Study of [F-18]VM4-037 NCT00884520 | Siemens Molecular Imaging | EARLY_Phase 1 |
| Completed | Phase I Study of a Statin + Erlotinib for Advanced Solid Malignancies With Focus on Squamous Cell Carcinomas a NCT00966472 | Ottawa Hospital Research Institute | Phase 1 |
| Completed | Fluorine F 18 EF5 Positron Emission Tomography in Assessing Hypoxia in Patients With Newly Diagnosed Stage I, NCT01020097 | Abramson Cancer Center at Penn Medicine | N/A |
| Completed | Correlation Between Skin Carotenoid Levels and Previous History of Skin Cancer NCT00836342 | Massachusetts General Hospital | — |
| Terminated | Zalutumumab in Combination With Radiotherapy in Head and Neck Cancer Patients Ineligible for Platinum Based Ch NCT00707655 | Genmab | Phase 1 / Phase 2 |
| Completed | An Open-Label Safety Study of API 31510 in a Topical Cream for in Situ Cutaneous Squamous Cell Carcinoma (SCCI NCT00652080 | BPGbio | Phase 1 / Phase 2 |
| Completed | The Impact of Total Body Skin Examination on Skin Cancer Detection NCT00765193 | Medical University of Graz | N/A |
| Unknown | Sexual Behavior in Head and Neck Cancer Patients NCT00662662 | M.D. Anderson Cancer Center | — |
| Withdrawn | Dose-Ranging Safety and Efficacy Study of Topical Creams Containing API 31510 for the Treatment of in Situ Cut NCT00605709 | BPGbio | Phase 2 |
| Terminated | Efficacy and Safety of OncoGel™ Added to Chemotherapy and Radiation Before Surgery in Subjects With Esophageal NCT00573131 | Boston Scientific Corporation | Phase 2 |
| Unknown | The Character of Perfusion Parameters Derived From MDCT Between Adenocarcinoma and Squamous Cell Carcinoma of NCT00751543 | National Taiwan University Hospital | N/A |
| Completed | Effect of the Subconscious on Mohs Micrographic Surgery NCT00374062 | Northwestern University | N/A |
| Completed | Radiotherapy Plus Panitumumab Compared to Chemoradiotherapy With Unresected, Locally Advanced Squamous Cell Ca NCT00547157 | Amgen | Phase 2 |
| Completed | PRISM (Panitumumab Regimen In Second-line Monotherapy of Head and Neck Cancer) NCT00446446 | Amgen | Phase 2 |
| Completed | Study of Addition of Panitumumab to Chemoradiation Therapy in Patients With Locally Advanced Head and Neck Can NCT00500760 | Amgen | Phase 2 |
| Completed | Serum Concentration of Lidocaine After Local Injection During Mohs Micrographic Surgery NCT00793169 | Northwestern University | — |
| Completed | Warning Signs of Squamous Cell Carcinoma and Prevention of SCC by at Risk Organ Transplant Recipients NCT01127737 | Northwestern University | N/A |
| Completed | Photochemical Tissue Bonding NCT00586040 | Massachusetts General Hospital | Phase 2 |
| Completed | Safety and Efficacy of Oral Midazolam for Perioperative Anxiety Relief of Patients Undergoing Mohs Micrographi NCT00578214 | Mayo Clinic | N/A |
| Terminated | Azacitidine and Cisplatin for Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Ne NCT00443261 | University of Kansas Medical Center | Phase 1 |
| Terminated | MRX, Radiation, and Chemotherapy for Patients With Resected Squamous Cell Carcinoma of the Head and Neck NCT00427102 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Phase 1 |
| Completed | Erlotinib in Women With Squamous Cell Carcinoma of the Vulvar NCT00476476 | Dana-Farber Cancer Institute | Phase 2 |
| Completed | Multi-Wavelength and Coherence Confocal Reflectance Microscopy of Pigmented and Non-Pigmented Lesions on the S NCT00574392 | Memorial Sloan Kettering Cancer Center | — |
| Completed | A Phase II Trial of Cetuximab and Bevacizumab in Patients With Recurrent or Metastatic Head and Neck Cancer NCT00409565 | National Cancer Institute (NCI) | Phase 2 |
| Terminated | Study of Induction Docetaxel, Cisplatin and 5-Fluorouracil NCT00400205 | Emory University | Phase 2 |
| Terminated | Identification of Key Blood Molecular Markers for Immunotherapy NCT00507702 | Stanford University | — |
| Completed | Symptom Assessment With Patient Surveys NCT01135823 | Stanford University | — |
| Completed | Confocal Reflectance Microscopy of Shave-Biopsy Sites on Skin in Vivo. NCT00601185 | Memorial Sloan Kettering Cancer Center | — |
| Completed | Palifermin for the Reduction of Oral Mucositis in Patients With Locally Advanced Head and Neck Cancer NCT00101582 | Swedish Orphan Biovitrum | Phase 3 |
| Withdrawn | Method Development and Assessment of the Effects of Tobacco Products on Oral Cavity Cells NCT01484769 | University of Louisville | — |
| Completed | Study Evaluating Temsirolimus in Advanced Stage Squamous Cell Carcinoma of the Head & Neck NCT00195299 | Wyeth is now a wholly owned subsidiary of Pfizer | — |
| Completed | Study the Expression of Annexin A1 and Its Potential Usage as a Prognostic Marker in Oral Cancer NCT00364715 | National Taiwan University Hospital | — |
| Completed | Molecular Effects of Short-Term Celecoxib Treatment on Head and Neck Squamous Cell Carcinoma NCT00596219 | Memorial Sloan Kettering Cancer Center | N/A |
| Completed | Vaccine Treatment for Advanced Non-Small Cell Lung Cancer NCT00073398 | NewLink Genetics Corporation | Phase 1 / Phase 2 |
| Completed | Photodynamic Therapy (PDT) With Metvix® 160 Milligrams/Gram Cream in Organ Transplant Participants With Non-me NCT00472459 | Galderma R&D | Phase 3 |
| Terminated | Evaluation of Hysterectomy After Chemoradiation Therapy for Stage IB2/II Cervical Cancer NCT01363466 | UNICANCER | Phase 3 |
| Completed | Cancer Risk in Carriers of the Gene for Xeroderma Pigmentosum NCT00046189 | National Cancer Institute (NCI) | — |
| Completed | Low-Dose Nedaplatin (CDGP:Cis-Diammine-Glycolatoplatinum)/5-FU Combined With Radiation for Esophageal Cancer NCT00197444 | Hamamatsu University | Phase 2 |
| Completed | Paclitaxel, Carboplatin And Low Dose Radiation As Induction Therapy In Locally Advanced Head And Neck Cancer NCT00176267 | Susanne Arnold | Phase 2 |
| Completed | Laryngeal Preservation in Pyriform Sinus Carcinoma NCT00770393 | Centre Hospitalier Universitaire de Saint Etienne | Phase 2 / Phase 3 |
| Completed | PS-341 and Radiation to Treat Advanced Cancer of the Head and Neck NCT00011778 | National Cancer Institute (NCI) | Phase 1 |
| Completed | Paclitaxel, Carboplatin and Radiotherapy as Induction Therapy in Locally Advanced Head and Neck Cancer NCT00176254 | Susanne Arnold | Phase 2 |
| Completed | Post-Operative Adjuvant Concurrent Chemoradiotherapy For High Risk Oral Cavity Squamous Cell Carcinoma Patient NCT00201383 | National Health Research Institutes, Taiwan | Phase 3 |
| Completed | Optical Biopsy of Human Skin in Conjunction With Laser Treatment NCT00540566 | University of California, Irvine | — |
| Completed | Chemoprevention Study of Oral Cavity Squamous Cell Carcinoma NCT00201279 | National Health Research Institutes, Taiwan | Phase 3 |
| Completed | Study of Taxotere, Cisplatin, 5-Fluorouracil, and Leucovorin for Squamous Cell Carcinoma of the Head and Neck NCT00139243 | Dana-Farber Cancer Institute | Phase 1 / Phase 2 |
| Completed | Spectroscopy With Surface Coils and Decoupling NCT00581815 | Memorial Sloan Kettering Cancer Center | Phase 1 |
| Completed | Combination Chemotherapy for Locally Advanced Squamous Cell Carcinoma of the Head and Neck NCT00139230 | Dana-Farber Cancer Institute | Phase 2 |
| Completed | The Effects of Upper Airway and Digestive Tract Tumors on the Immune System NCT00001603 | National Institute on Deafness and Other Communication Disorders (NIDCD) | — |
| Completed | A Pilot Study of Paclitaxel With Radiation Therapy for Locally Advanced Head and Neck Cancer NCT00001442 | National Cancer Institute (NCI) | Phase 1 |
| Withdrawn | Assessment of Head and Neck Tumor Hypoxia Using 18F-Fluoromisonidazole NCT00038038 | M.D. Anderson Cancer Center | N/A |
| Unknown | Free Radical Level in SCC of Tongue Patients Tumor, Serum and Saliva NCT00426062 | Sheba Medical Center | — |
| Available | Expanded Access to Immunomodulatory AVM0703 for Solid Tumor and Blood Cancer Patients NCT05974410 | AVM Biotechnology Inc | — |
| No Longer Available | Expanded Access Use of DKN-01 for the Treatment of Advanced Solid Tumors NCT04681248 | Leap Therapeutics, Inc. | — |