NCT00895349

Impact of Positron Emission Tomography (PET) Imaging in Women With Locally Advanced Cervical Cancer (PET LACE Trial)

The Impact of Positron Emission Tomography (PET) Imaging in Women With Locally Advanced Cervical Cancer

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 171 (actual)
• Sponsor: Ontario Clinical Oncology Group (OCOG) · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this trial is to improve the clinical management and outcome of patients with locally advanced cervical cancer by using positron emission tomography-computed tomography (PET-CT) imaging. There is considerable debate worldwide regarding the utility of PET for staging cervical cancer. Although there are studies on the accuracy (sensitivity and specificity) of PET in cervical cancer, there are currently no prospective randomized studies on how PET information affects treatment decisions and outcomes.

Detailed description

Cervical cancer is the second most common cause of cancer deaths worldwide. In Canada, it is estimated that in 2009 there will be 1,300 new cases of cervical cancer and that 380 women will die of this disease. The corresponding 2009 data for Ontario is 500 new cases and 140 deaths. In Canada, cervical cancer screening with the Pap test allows for the diagnosis and curative treatment of precancerous lesions of the cervix or early cervical cancers. Symptoms of cervical cancer include vaginal bleeding and discharge. Unfortunately these are often associated with more advanced disease. The costs associated with health care are increasing. PET is an expensive imaging modality. Given that resources for health care are not unlimited, there needs to be high quality evidence of an intervention such as PET's efficacy.

Conditions

• Cervical Cancer
• Squamous Cell Carcinoma
• Adenosquamous Carcinoma
• Adenocarcinoma

Interventions

Type	Name	Description
PROCEDURE	CT Abdomen and Pelvis scan + whole body PET-CT scan	Pre-treatment scan
PROCEDURE	CT Abdomen and Pelvis scan	Pre-treatment scan

Timeline

• Start date: 2010-04-01
• Primary completion: 2014-06-01
• Completion: 2019-08-01
• First posted: 2009-05-08
• Last updated: 2020-01-29

Locations

6 sites across 1 country: Canada