| Not Yet Recruiting | Signatera Assessment in Early-Stage Endometrial Cancer Endometrial Cancer | N/A | 2026-05-01 |
| Recruiting | Signatera-Guided CDK4/6 Inhibitor Therapy in Breast Cancer Breast Neoplasms, Carcinoma, Ductal, Breast, Receptors, Estrogen (for ER-positive Requirement) | N/A | 2026-03-24 |
| Recruiting | Sample Collection for Ongoing Research and Product Evaluation Study Breast Cancer, Lung Cancer, Muscle Invasive Bladder Cancer | — | 2025-07-21 |
| Recruiting | Evaluation of the Natera Colorectal Cancer Screening Test in an Average Risk Population (FIND-CRC) Colo-rectal Cancer | — | 2025-05-30 |
| Active Not Recruiting | A Comparative Effectiveness Study in Heart Transplant Patients of Rejection Surveillance With Cell-free DNA Ve Heart Transplant Failure and Rejection | N/A | 2024-06-10 |
| Recruiting | Prospective Collection of Samples to Enable the Development of Natera Screening Assay for Early Cancer Detecti Colorectal Cancer Screening | — | 2024-01-26 |
| Recruiting | EXpanding Prenatal Cell Free DNA Screening Across moNogenic Disorders (EXPAND) Single Gene NIPT | — | 2024-01-25 |
| Withdrawn | Donor-Derived Cell-free DNA to DETect REjection in Cardiac Transplantation Heart Transplant Failure and Rejection | N/A | 2023-01-01 |
| Completed | Development of Non-invasive Cell-free DNA to Supplant Invasive Biopsy in Heart Transplantation Heart Transplant | — | 2022-12-12 |
| Active Not Recruiting | LAMBDA 002 (Lung Registry) Study Lung Transplant Rejection | — | 2022-11-04 |
| Completed | Clinical Utility of the Addition of a SNP-based NIPT Zygosity Determination in Twin Pregnancy Management. Twin to Twin Transfusion Syndrome, Pregnancy Complications, Multiple Gestation; Maternal Care | — | 2021-10-01 |
| Active Not Recruiting | Prospera Test Evaluation in Cardiac Transplant (ProTECT) Heart Transplant Rejection | — | 2021-10-01 |
| Completed | Verification of Risk Assignment for Whole Chromosome Using SNP-based NIPT in Vanishing Twin Pregnancies Vanishing Twin, Trisomy 21, Trisomy 13 | — | 2021-07-22 |
| Unknown | Renasight Clinical Application, Review and Evaluation (RenaCARE) Study Kidney Diseases | N/A | 2021-06-07 |
| Completed | BESPOKE Study of ctDNA Guided Immunotherapy Colorectal Cancer, Melanoma, Non-small Cell Lung Cancer | — | 2021-05-28 |
| Unknown | BESPOKE Study of ctDNA Guided Therapy in Colorectal Cancer Colorectal Cancer, Colon Cancer | — | 2020-04-24 |
| Active Not Recruiting | The PROspera Kidney Transplant ACTIVE Rejection Assessment Registry (ProActive) Kidney Transplant Rejection | — | 2019-11-06 |
| Completed | Study for the Prediction of Active Rejection in Organs Using Donor-derived Cell-free DNA Detection Transplant Rejection, Allograft Rejection, Complications | — | 2018-09-14 |
| Terminated | Natera Ovarian Cancer Detection Assay Adnexal Mass | — | 2017-12-14 |
| Completed | SNP-based Microdeletion and Aneuploidy RegisTry (SMART) 22q11 Deletion Syndrome, DiGeorge Syndrome, Trisomy 21 | — | 2015-04-01 |
| Completed | High Risk Multiple Gestation Study Trisomy 13, Trisomy 18, Trisomy 21 | — | 2014-08-01 |
| Completed | Multiple Gestation Study Trisomy 13, Trisomy 18, Trisomy 21 | — | 2013-03-01 |
| Completed | Development of Non-invasive Prenatal Screening Test for Microdeletions Based on Fetal DNA Isolated From Matern Trisomy 21, Trisomy 18, Trisomy 13 | — | 2012-11-01 |
| Completed | Development of Non-invasive Prenatal Test for Microdeletion and Other Genetic Syndromes Based on Cell Free DNA Microdeletion Syndromes, Trisomy 21, Trisomy 18 | — | 2012-10-01 |
| Withdrawn | Multi-disease Carrier Screening Test Validation Spinal Muscular Atrophy (SMA), Carrier Screening, Genetic Testing | — | 2012-08-01 |
| Completed | Collection of Maternal Blood Samples for Development of Non-invasive Prenatal Diagnostic Testing Pregnancy Following IVF With PGS/PGD | — | 2012-02-01 |
| Terminated | Prenatal Non-invasive Aneuploidy Test Utilizing SNPs Trial Trisomy 13, Trisomy 18, Trisomy 21 | — | 2012-01-01 |
| Completed | Non-invasive Prenatal Diagnostic Validation Study Chromosome 13 Aneuploidy, Chromosome 18 Aneuploidy, Chromosome 21 Aneuploidy | — | 2011-09-01 |
| Completed | Clinical Use of Parental Support To Detect Single Gene Mutations Single Gene Disorders | — | 2010-09-01 |
| Terminated | Impact of Parental Support on Pregnancy Outcomes (IPSO) Trial- Day 3 Preimplantation Genetic Screening (PGS) W Preimplantation Gentic Screening (PGS), In Vitro Fertilization (IVF), Preimplantation Genetic Diagnosis (PGD) | Phase 4 | 2010-09-01 |
| Completed | Concurrent Single Gene and 24 Chromosome Aneuploidy Preimplantation Genetic Diagnosis (PGD) Any Single Gene Disorder (Cystic Fibrosis, Tay-Sachs) | N/A | 2009-11-01 |