NCT06199947

Study of the Role of Oncostatin M in Head and Neck Squamous Cell Carcinoma

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 119 (estimated)
• Sponsor: Poitiers University Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 99 Years
• Healthy volunteers: Not accepted

Summary

The ROMCOR study will be interested in the impact and the role of oncostatin M (OSM), a cytokine belonging to IL-6 superfamily, in the physiopathology of head and neck squamous cell carcinoma. The study team will study the impact of the presence of OSM and its main receptor OSM-R2 on several survival outcomes (overall survival, progression free survival) by multiple technics such as immunohistochemistry, transcriptomic in situ assays and spatial transcriptomic. Furthermore, the study team will try to show a link between serum level of several cytokines and in situ tumoral OSM.

Conditions

• Head and Neck Cancer
• Cytokine

Interventions

Type	Name	Description
OTHER	Biopsies and Blood collection	Each participant will have 2 additionnal biopsies during his/her diagnostic endoscopy plus two blood test during his/her inclusion

Timeline

• Start date: 2024-02-01
• Primary completion: 2025-06-01
• Completion: 2025-12-01
• First posted: 2024-01-10
• Last updated: 2024-01-10