NCT06480903

Exploratory Study of EBV DNA Titre Clearance Whilst on Proton Beam Therapy

Exploratory Study of Plasma Epstein Barr Virus (EBV) DNA Clearance During Proton Beam Therapy (PBT) for Nasopharyngeal Carcinoma (NPC)

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 10 (estimated)
• Sponsor: The Christie NHS Foundation Trust · Academic / Other
• Sex: All
• Age: 8 Years – 30 Years
• Healthy volunteers: Not accepted

Summary

How does plasma Epstein-Barr Virus (EBV) DNA level change during definitive radiation therapy for nasopharyngeal carcinoma (NPC) in the teenage and young adult cohort and does it correlate with outcomes?

Detailed description

Children with NPC achieve superior survival outcomes compared to adults (10) and the prognostic value of plasma Epstein-Barr Virus (EBV) DNA has not been studied in children. Integration of MRI into early treatment response assessment will add further prognostic value and permits response-adapted therapy which can improve quality of survivorship children through toxicity reduction. It also allows identification of patients who either have had or are likely to have a suboptimal response to treatment, facilitating the potential consideration of treatment escalation. The sample size of this study is not intended to change clinical practice, but rather provide a basis for international collaboration to achieve larger patient numbers.

Conditions

• Nasopharyngeal Carcinoma
• Head and Neck Cancer
• Nasopharyngeal Cancer
• Epstein-Barr Virus

Timeline

• Start date: 2024-08-30
• Primary completion: 2026-08-30
• Completion: 2026-08-30
• First posted: 2024-06-28
• Last updated: 2024-06-28