| Not Yet Recruiting | Ketamine and Dexmedetomidine for Delirium in Joint Arthroplasty NCT06963294 | Istinye University | N/A |
| Not Yet Recruiting | Correlation Between Preoperative Sleep and Postoperative Brain and Renal Dysfunction NCT07518992 | Xijing Hospital | — |
| Not Yet Recruiting | EEG-Guided Analgesic Titration During General Anesthesia to Improve Early Neurocognitive Recovery in Older Pat NCT04443517 | Columbia University | N/A |
| Not Yet Recruiting | Impact of Esketamine on Delayed Neurocognitive Recovery in Older Patients NCT07523334 | Peking University First Hospital | Phase 4 |
| Not Yet Recruiting | Orthopedic Procedures and Postoperative Delirium in Older Adults in the Czech Republic NCT07432009 | Tomas Bata Hospital, Czech Republic | — |
| Not Yet Recruiting | Verification of a New Predictive Delirium Score in Adults With Elective Cardiac Valve or Bypass Surgery With P NCT07276503 | University Hospital Tuebingen | — |
| Enrolling By Invitation | The Effect of Omega 3 Supplementation on Postoperative Delirium in Elderly Patients Undergoing Major Cardiac S NCT06434948 | University of Missouri-Columbia | Phase 2 |
| Not Yet Recruiting | Effect of Perioperative IV Ibuprofen on Cerebral Oxygenation and Postoperative Cognition During One-Lung Venti NCT07399184 | Ondokuz Mayıs University | N/A |
| Recruiting | Preoperative Distress and Postoperative Delirium in Elderly Patients Undergoing Major Orthopedic Surgery NCT07512752 | Elazıg Fethi Sekin Sehir Hastanesi | — |
| Not Yet Recruiting | Association of Preoperative Hippocampal Glucose Metabolism With Postoperative Delirium in Older Diabetic Patie NCT07369466 | Chinese PLA General Hospital | — |
| Not Yet Recruiting | Association of Optic Nerve Sheath Diameter and Postoperative Delirium NCT07249047 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | N/A |
| Recruiting | Inflammatory Biomarkers and Postoperative Delirium in Pediatric Circumcision NCT07323485 | Ankara Etlik City Hospital | — |
| Recruiting | Dexmedetomidine vs Midazolam in Coronary Artery By-pass Surgery NCT07411794 | Cumhuriyet University | N/A |
| Not Yet Recruiting | Creatine and Perioperative Brain Health NCT07310043 | Massachusetts General Hospital | N/A |
| Recruiting | Naples Prognostic Score for Predicting Postoperative Delirium NCT07297017 | South Valley University | — |
| Not Yet Recruiting | Remimazolam for Reducing Postoperative Delirium in Elderly Patients Undergoing Laparoscopic Gastrectomy NCT07351474 | The First Affiliated Hospital with Nanjing Medical University | N/A |
| Not Yet Recruiting | The Effect of Reversal of Remimazolam Sedation With Flumazenil on Cognitive Function in Patients Undergoing Hi NCT07277881 | Medical University of Gdansk | Phase 4 |
| Not Yet Recruiting | Paracetamol and Mannitol Injection and Postoperative Delirium NCT07235995 | Xiangya Hospital of Central South University | Phase 4 |
| Not Yet Recruiting | Electroacupuncture for Preventing Postoperative Delirium in Older Adults Undergoing Total Knee Arthroplasty NCT06564506 | Fujian Provincial Hospital | N/A |
| Recruiting | Postoperative Delirium in Patients Undergoing Cardiac Surgery NCT07239648 | Xijing Hospital | — |
| Not Yet Recruiting | Stress Hyperglycemia Ratio and Postoperative Delirium NCT07194096 | Rao Sun | — |
| Recruiting | Daridorexant to Prevent Post-cardiotomy Delirium NCT07217912 | University of Rochester | Phase 2 |
| Not Yet Recruiting | Perioperative GDNF as a Predictive Factor for Postoperative Delirium and Adverse Neurological Outcomes in Pedi NCT07192549 | General Hospital of Ningxia Medical University | N/A |
| Not Yet Recruiting | EEG-TMS Intervening Against Postoperative Delirium NCT07100197 | RenJi Hospital | N/A |
| Not Yet Recruiting | The Effect of Bupivacaine Liposome Preemptive Analgesia on Postoperative Pain and Delirium in Elderly Patients NCT07066111 | Nanjing First Hospital, Nanjing Medical University | Phase 4 |
| Not Yet Recruiting | Effects of Different Preoperative Oral Rehydration Protocols in Undergoing Thoracoscopic Radical Lung Cancer S NCT07042503 | Fujian Medical University Union Hospital | — |
| Recruiting | Intraoperative Infusion of Either Lidocaine or Dexmedetomidine on Regional Cerebral Oxygen Saturation and Post NCT07108764 | Tanta University | N/A |
| Recruiting | Dexmedetomidine in Reducing Postoperative Delirium in Cardiac Surgery Patients NCT06619912 | Xijing Hospital | Phase 3 |
| Recruiting | Digital Sleep Optimization for Brain Health Outcomes in Older Surgical Patients NCT06375265 | Massachusetts General Hospital | N/A |
| Recruiting | Effect of Oral Melatonin Versus Intraoperative Lidocaine Infusion on Incidence of Postoperative Delirium in El NCT06768580 | Tanta University | N/A |
| Recruiting | Correlation Analysis of POD and pNCD in Elderly Spinal Surgery Patients NCT06466083 | Xuanwu Hospital, Beijing | — |
| Completed | Daridorexant to Prevent Delirium After Heart Surgery NCT06630390 | University of Rochester | Phase 2 |
| Recruiting | Correlation Analysis of POD and pNCD in Elderly Patients With Gastrointestinal Neoplasms NCT06466096 | Xuanwu Hospital, Beijing | — |
| Recruiting | Intraoperative Diagnosis of Neurocognitive Complications Via Electroencephalographic Analysis NCT06545786 | Federal Research and Clinical Centre of Intensive Care Medicine and Rehabilitology | — |
| Completed | Comparison of the Postoperative Analgesic Effectiveness of Erector Spinae Plane Block Versus Its Combination W NCT07304635 | Ankara University | N/A |
| Recruiting | Risk Warning Model of Postoperative Delirium and Long-term Cognitive Dysfunction in Elderly Patients NCT06423547 | Xuanwu Hospital, Beijing | — |
| Recruiting | Digitalized Clinical Decision Support for the Prevention of Postoperative Delirium (POD) NCT06445153 | Charite University, Berlin, Germany | N/A |
| Recruiting | Effects of Nutritional Support on Postoperative Delirium NCT06467552 | Yonsei University | N/A |
| Recruiting | Predictive Effect of TGF-β and INS-PI3K-AKT Related Proteins for POD in Diabetes Patients NCT06426953 | Xie Kangjie | — |
| Completed | Erector Spinae Plane Block vs Local Infiltration Following Fusion Surgery NCT06199999 | Rashmi Mueller | Phase 2 |
| Completed | Effect of Electroencephalography Guided General Anesthesia on Postoperative Delirium in Children NCT06400706 | Aydin Adnan Menderes University | N/A |
| Completed | The Impact of Repetitive Transcranial Magnetic Stimulation on the Prognosis of Elderly Surgical Patients NCT06392919 | Affiliated Hospital of Nantong University | N/A |
| Completed | The Effect of Transcutaneous Electrical Acupoint Stimulation Combined With Transcutaneous Auricular Vagus Nerv NCT07045090 | Affiliated Hospital of Nantong University | N/A |
| Recruiting | The Effect of 40 Hz Transcranial Stimulation on the Incidence of Delirium After Total Hip Replacement or Total NCT06522087 | Henan Provincial People's Hospital | N/A |
| Recruiting | Effect of Prophylactic Application of 40Hz Transcranial Stimulation in AICU on Incidence of Postoperative Deli NCT06542978 | Henan Provincial People's Hospital | N/A |
| Completed | Stanford PIPRA Validation Study in an Elderly Orthopedic Population NCT06567574 | Stanford University | — |
| Recruiting | CEReBral AutorEgulation in Non-cardiac SuRgery and Relationship to Postoperative DeliriUm State NCT06133842 | Beth Israel Deaconess Medical Center | — |
| Recruiting | Non-pharmacological Prevention of POD in Frailty Elderly Undergoing Elective Surgery Applied by Nursing Teams NCT05993754 | Pontificia Universidad Catolica de Chile | N/A |
| Completed | Intraoperative Diaphragmatic Neuromodulation NCT06518707 | Beijing Sanbo Brain Hospital | N/A |
| Completed | Machine Learning Algorithm for Predicting Postoperative Delirium in Elderly Patients After Thoracic Surgery NCT06226480 | Affiliated Hospital of Nantong University | — |
| Completed | The Effect of Anesthesia Depth Monitoring on Emergence Delirium in Pediatrics NCT06323616 | Istanbul University | N/A |
| Not Yet Recruiting | Prevention of Postoperative Delirium in Elderly Patients NCT06248684 | Technical University of Munich | N/A |
| Recruiting | Remimazolam vs. Propofol: Impact on Postoperative Delirium in Neurosurgical Patients NCT06115031 | Samsung Medical Center | N/A |
| Recruiting | Perioperative Dexmedetomidine on Postoperative Delirium in Patients With Brain Tumors NCT06164314 | Beijing Tiantan Hospital | N/A |
| Completed | Predictive Efficacy of Ratio of Median Frequency to Spectral Edge Frequency Used in the Depth of Anaesthesia M NCT06644209 | Ankara University | — |
| Completed | STimulation Electronically of Acupoints for Postoperative Delirium in elderlY Patients NCT06161662 | Zhihong LU | N/A |
| Unknown | Efficacy of BIS Monitoring in Deep Hypnotic State NCT06177847 | Indonesia University | N/A |
| Unknown | Dexmedetomidine Prevents Postoperative Delirium After Deep Brain Stimulation in Patients With Parkinson's Dise NCT05197439 | Beijing Tiantan Hospital | N/A |
| Completed | Postoperative Stroke and Epiaortic Ultrasound in CABG NCT07101393 | Ataturk University | — |
| Completed | Association Between Preoperative Hyperglycemia and Postoperative Delirium in Geriatric Hip Fracture Patients NCT06473324 | Wenbo Ding | — |
| Completed | Prevalence and Risk Factors for Postoperative Delirium 48 Hours After Surgery NCT06127901 | Fundacin Biomedica Galicia Sur | — |
| Unknown | Cyclopofol Versus Propofol for Postoperative Delirium in Elderly Patients Having Orthopedic Surgery NCT06046638 | RenJi Hospital | Phase 4 |
| Completed | EEG Characteristics and Postoperative Delirium NCT06102967 | Zhuo Liu | — |
| Recruiting | The Effect of Desflurane Versus Sevoflurane Versus Propofol on Postoperative Delirium NCT05990790 | Medical University of Vienna | Phase 4 |
| Active Not Recruiting | Electroencephalographic Biomarker to Predict Postoperative Delirium NCT05992506 | University of Chile | — |
| Recruiting | The Effects of Anesthetics on Brain Network Connectivity in Patients With Supratentorial Glioma NCT06138340 | Beijing Tiantan Hospital | — |
| Completed | Comparison of DRS-R-98 and 3D-CAM in the Assessment of Postoperative Delirium in Elderly Patients NCT05992818 | Istanbul University | — |
| Unknown | Different Administration Routes of Dexmedetomidine on Postoperative Delirium NCT05952050 | Boston Intelligent Medical Research Center, Shenzhen United Scheme Technology Co., Ltd. | N/A |
| Completed | The Preventive Effect of Different Doses of Intranasal Insulin on Postoperative Delirium NCT06443957 | The First Hospital of Jilin University | N/A |
| Recruiting | Decreasing Preoperative Stress to Prevent Postoperative Delirium and Postoperative Cognitive Decline in Cardia NCT05036538 | Heart and Brain Research Group, Germany | N/A |
| Unknown | Characterisation of Gut Microbiota in Patients Undergoing Gastrointestinal Surgery With Postoperative Delirium NCT04316910 | China Medical University, China | — |
| Completed | The Effect of Child Choice With Accompanying Parent on Postoperative Delirium During Induction of Anesthesia NCT05931770 | Karaman Training and Research Hospital | — |
| Unknown | Effect of Preoperative Olfactory Training on Postoperative Delirium in the Elderly Undergoing Orthopedic Surge NCT05908318 | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | N/A |
| Recruiting | Accompanying Scientific Program for the Quality Contract Prevention of Postoperative Delirium in the Care of O NCT05847010 | Charite University, Berlin, Germany | — |
| Completed | Role of Natural Light in the Prevention of Delirium After Cardiac Surgery: a Prospective Observational Study W NCT05936944 | Azienda Ospedaliero-Universitaria di Parma | — |
| Completed | Dexmetomedine for Post Operative Delirium in Elderly Patients Undergoing Elective Total Knee Replacement Under NCT05707741 | Menoufia University | N/A |
| Unknown | Effect of Preoperative Sarcopenia on Postoperative Delirium in Elderly Patients Undergoing Gastrointestinal Su NCT05847296 | Second Affiliated Hospital of Nanchang University | — |
| Recruiting | Efficacy of Suvorexant on Post-operative Sleep Disturbance NCT05823844 | Columbia University | Phase 4 |
| Unknown | Correlation Between Perioperative EEG Features and Delirium After General Anesthesia NCT06082024 | Fuzhou Hua | — |
| Unknown | Autonomous Nervous System Regulated Paediatric Anaesthesia With Dexmedetomidine or Placebo NCT05785689 | University of Southern Denmark | Phase 4 |
| Unknown | Plasma Proteomics in Patients With Postoperative Delirium NCT05772026 | Xuzhou Central Hospital | — |
| Unknown | Automated Pupillometry in Patients Underwent Cardiac Surgery to Predict Postoperative Delirium NCT06255132 | Azienda Ospedaliera Universitaria Integrata Verona | N/A |
| Completed | Perioperative Multimodal General AnesTHesia Focusing on Specific CNS Targets in Patients Undergoing carDiac su NCT05279898 | Beth Israel Deaconess Medical Center | N/A |
| Recruiting | The Caffeine, Postoperative Delirium, and Change in Outcomes After Surgery (CAPACHINOS-2) Study NCT05574400 | University of Michigan | Phase 2 |
| Completed | EEG Spectrogram, Brain Vulnerability and POD NCT05368272 | University of Nottingham | — |
| Recruiting | Impact of Personalised Cardiac Anaesthesia and Cerebral Autoregulation on Neurological Outcomes in Patients Un NCT05595954 | University Hospital, Basel, Switzerland | — |
| Completed | Dexmedetomidine in Reducing Incidence of Emergence Agitation After Nasal Surgery NCT05634148 | Security Forces Hospital | Phase 3 |
| Completed | Sugammadex and Neostigmine in Pediatric Patients NCT05618236 | Marmara University | — |
| Unknown | Neuroimaging Combining Biomarkers for Identifying Long-term Cognitive Dysfunction and Delirium NCT05594966 | RenJi Hospital | — |
| Unknown | Relationship Between Perioperative Related Factors and Inflammatory Markers and Postoperative Delirium in Elde NCT05341531 | Beijing Friendship Hospital | — |
| Unknown | Peripheral Blood Single Cell Sequencing Analysis of POD and CPSP in Elderly Patients After Total Knee Arthropl NCT05572307 | Xuzhou Central Hospital | — |
| Unknown | Effects of Perioperative Transauricular Vagus Nerve Electrical Stimulation on POD, POCD and CPSP NCT05439707 | Xuzhou Central Hospital | N/A |
| Withdrawn | Buccal Acupuncture for Delirium Treatment in Older Patients Recovering From Orthopedic Surgery NCT05537155 | Peking University First Hospital | N/A |
| Unknown | Effects of Perioperative Operating Room Environment on Postoperative Delirium NCT05551026 | The Second Affiliated Hospital of Chongqing Medical University | — |
| Completed | An Observational Study on the Relationship Between Tear Metabolomics and POD NCT05548153 | The Second Affiliated Hospital of Chongqing Medical University | — |
| Recruiting | Intraoperative Infusion of Dexmedetomidine for Prevention of Postoperative Delirium in Elderly Patients NCT05168280 | Beijing Tiantan Hospital | N/A |
| Unknown | Postoperative Delirium in the ICU Setting of an Eastern European Centre NCT05474872 | Institutul Regional de Gastroenterologie & Hepatologie Prof. dr. Octavian Fodor | — |
| Unknown | fMRI Feasibility Older Hip Fracture Surgery NCT05081726 | University of Nottingham | — |
| Unknown | Biomarkers and Postoperative Delirium in Elderly Patients NCT05454228 | Henan Provincial People's Hospital | — |
| Unknown | Effect of RIPC on the Prevention of POD in Patients Undergoing Cardiac Surgery NCT05434455 | Shanghai Zhongshan Hospital | N/A |
| Completed | Multi-omics Analyses Reveal Microbiota-gut-brain Axis in ICU Patients With Post-cardiac Surgery Delirium NCT05628480 | China National Center for Cardiovascular Diseases | — |
| Unknown | Key circRNA Identification of Postoperative Delirium in Elderly Patients Undergoing Cardiac Surgery NCT05743660 | Xuzhou Central Hospital | — |
| Unknown | Cytokines, POD, Health Status, Older Hip Fracture NCT05096507 | University of Nottingham | — |
| Recruiting | The Role of Emotional and Orientation Support in Prevention of Postoperative Delirium Among Elderly Surgical P NCT05140993 | Barak Cohen, MD | N/A |
| Completed | The Effect of Desflurane Versus Sevoflurane on Postoperative Recovery NCT05331027 | Medical University of Vienna | Phase 4 |
| Unknown | Researching the Affect of Sevoflurane in Cardiac Surgery on Delirium NCT05365165 | Derince Training and Research Hospital | — |
| Completed | The Effects of Subanesthetic S-ketamine on Postoperative Delirium and Cognitive Function in the Elderly Underg NCT05242692 | Affiliated Cancer Hospital & Institute of Guangzhou Medical University | EARLY_Phase 1 |
| Unknown | Total Intravenous Anesthesia Versus Sevoflurane Anesthesia for Endovascular Thrombectomy in Acute Ischemic Str NCT05493813 | Taipei Veterans General Hospital, Taiwan | N/A |
| Recruiting | Association Between Local Cerebral Oxygenation Monitoring and Postoperative Delirium in Carotid Endarterectomy NCT05198635 | Beijing Tiantan Hospital | — |
| Completed | Treatment of Postoperative Delirium With Continuous Theta Burst Stimulation NCT05239897 | RenJi Hospital | N/A |
| Unknown | Shenfu Injection for Postoperative Delirium (SFI for POD) NCT05179252 | Shandong University of Traditional Chinese Medicine | N/A |
| Unknown | Efficacy of Erector Spinae Plane Block on Postoperative Delirium in Patients Undergoing Lumbar Spine Surgery NCT05276648 | Aydin Adnan Menderes University | N/A |
| Completed | Preoperative BAMCOG and Cortisol and Postoperative DeltaScan in AVR Patients (Aortic Valve Replacement) NCT05209555 | Catharina Ziekenhuis Eindhoven | — |
| Unknown | C-reactive Protein，Homocysteine，Postoperative Delirium NCT05164965 | Shanghai 10th People's Hospital | — |
| Unknown | The Impact of the Implementation of BIS on the Incidence of Postoperative Delirium NCT04736303 | University of Thessaly | N/A |
| Terminated | Dexmedetomidine Supplemented Analgesia and Delirium After Hip Fracture Surgery NCT04955249 | Peking University First Hospital | Phase 4 |
| Unknown | Conscious Sedation for Transcatheter Aortic Valve Implantation NCT05462938 | University of Ioannina | N/A |
| Unknown | The Neuro-epigenetics Biomarkers of Postoperative Delirium in Elderly Patients Undergoing Hip/Knee Replacement NCT04923243 | Zhongnan Hospital | — |
| Completed | Greek Validation of ACE III Test in Perioperative Patients NCT04312516 | Aristotle University Of Thessaloniki | — |
| Recruiting | A Clinical Trial of Intravenous Lidocaine After Spinal Surgery to Prevent Delirium and Reduce Pain NCT05010148 | University of California, San Francisco | Phase 3 |
| Unknown | The Southeast and East Asian Post-Operative Delirium (SEAPOD) Study NCT04999891 | National University Hospital, Singapore | — |
| Unknown | Effect of Es-ketamine on Postoperative Delirium Among Old Patients With Lobectomy NCT04969523 | Zhongnan Hospital | N/A |
| Completed | Diagnosis, Incidence and Consequences of PACU-Delirium NCT04978870 | Universitätsklinikum Hamburg-Eppendorf | — |
| Unknown | Modified Tian Wang Bu Xin Dan Hydrogel Patch in Preventing Postoperative Delirium in Elderly Patients NCT04947761 | Chinese PLA General Hospital | Phase 4 |
| Completed | Continuous Theta Burst Stimulation (cTBS) and Postoperative Delirium NCT04661904 | Shanghai 10th People's Hospital | N/A |
| Completed | Projection of Visual Material on Postoperative Delirium in Patients Undergoing Cardiac Surgery NCT05932394 | University of Huelva | N/A |
| Completed | The Relationship Between Zonulin and Interleukin-8 Levels and Postoperative Delirium Development NCT04875182 | Dr. Gokhan Vural | — |
| Unknown | The Effect of Desflurane on Postopertative Cognitive Dysfunction NCT04541823 | Beijing Chao Yang Hospital | Phase 4 |
| Completed | Methylene Blue and Postoperative Neurocognitive Disorders NCT04529265 | Fudan University | N/A |
| Unknown | Prevention of Postoperative Delirium After Acute Surgery NCT04857125 | Bispebjerg Hospital | N/A |
| Recruiting | Singapore Perioperative Ageing Study (Sing-PAS) NCT04792554 | National University Hospital, Singapore | — |
| Completed | Postoperative Neurocognitive Dysfunction: Is There Any Place for Emergency Agitation: A Prospective Cohort Tri NCT04820595 | Negovsky Reanimatology Research Institute | — |
| Active Not Recruiting | WashIn /WashOut Procedure To Prevent Agitation During Recovery After Inhalational Anesthesia With Sevoflurane NCT04765488 | I.M. Sechenov First Moscow State Medical University | N/A |
| Completed | Association Between Burst Suppression During Anesthetic Induction With Postoperative Delirium in Cardiac Surge NCT04713644 | Pontificia Universidad Catolica de Chile | — |
| Unknown | Incidence of Postoperative Delirium After Cardiac Surgery in Adults. NCT04828902 | Medical University of Gdansk | — |
| Completed | Dexmedetomidine Alleviates Postoperative Delirium After Brain Tumor Resections NCT04674241 | Beijing Tiantan Hospital | N/A |
| Recruiting | Incidence of Postoperative Delirium in Elderly Patients Undergoing Non-cardiac Surgery NCT04707794 | Sir Ganga Ram Hospital | — |
| Completed | The Role of Remazolam in Reducing the Incidence of Postoperative Delirium in Elderly Patients NCT05466279 | Fang Jun | N/A |
| Completed | Electroencephalographic Biomarker to Predict Acute Post-operatory Cognitive Dysfunction NCT04214496 | University of Chile | — |
| Completed | Association Between Fibrinogen-to-albumin Ratio and Delirium After Deep Brain Stimulation Surgery in Parkinson NCT05833308 | Changhai Hospital | — |
| Unknown | Risk Factors for Postoperative Delirium in Elderly Patients Undergoing Major Non-Cardiac Surgery in Singapore NCT04617210 | National University Hospital, Singapore | — |
| Unknown | A Pilot Trial Evaluating the Effect of Tropisetron on Postoperative Cognitive Dysfunction After Cardiac Surger NCT04195204 | Beijing Chao Yang Hospital | Phase 4 |
| Recruiting | Building a Platform for Precision Anesthesia in the Geriatric Surgical Patient NCT03839784 | Stanford University | — |
| Recruiting | Increasing Preoperative Cognitive Reserve to Prevent Postoperative Cognitive Dysfunction in Cardiac Surgical P NCT04493996 | Heart and Brain Research Group, Germany | N/A |
| Completed | Melatonin to Decrease the Incidence of Postoperative Delirium in Geriatric Patients NCT04483596 | Cairo University | — |
| Recruiting | Bilateral Bispectral Index, Asymmetries and Post-operative Delirium NCT06761573 | IRCCS Azienda Ospedaliero-Universitaria di Bologna | — |
| Unknown | Association Between the Brain Excitability and Postoperative Delirium in Patients Undergoing Heart Valve Repla NCT05001425 | General Hospital of Ningxia Medical University | — |
| Unknown | The Disorder of Circadian Clock Gene and Early Cognitive Dysfunction After General Anesthesia NCT04421872 | Shengjing Hospital | N/A |
| Unknown | Correlation of Electroencephalogram With Postoperative Delirium During Cardiac Surgery NCT04943939 | General Hospital of Ningxia Medical University | — |
| Unknown | Postoperative Cognitive Dysfunction in Elderly Urologic Oncology Patients (POCD) NCT04837391 | Istanbul University | — |
| Completed | Relationship Between Perioperative Sleep Disturbance and Postoperative Delirium NCT05457387 | Chinese PLA General Hospital | — |
| Completed | Comparison of Postoperative Delirium in Elders Anaesthetised With Midazolam and Without Midazolam NCT05456230 | Chinese PLA General Hospital | — |
| Completed | Effects of Preoperative Anxiety and Preemptive Analgesia on Postoperative Delirium in Septo/Rhinoplasty Surger NCT07010042 | Zonguldak Bulent Ecevit University | — |
| Completed | Postoperative Delirium in Elderly Patients Undergoing Major Non-Cardiac Surgery in Singapore NCT04330950 | National University Hospital, Singapore | — |
| Completed | Intraoperative EEG Monitoring and Postoperative Delirium in Elderly Patients With Sevoflurane Anesthesia NCT04292561 | The First Affiliated Hospital of Anhui Medical University | N/A |
| Completed | Suvorexant and Sleep/Delirium in ICU Patients NCT04092894 | Beth Israel Deaconess Medical Center | Phase 4 |
| Unknown | Survey Assessing the Level of Knowledge of Postoperative Delirium in Poland. NCT04250610 | Pomeranian Medical University Szczecin | — |
| Completed | Taking Brain Monitoring to the Next Level NCT04246320 | University of California, Los Angeles | N/A |
| Completed | Association of Plasma Biomarkers for Neurological Injury and Postoperative Delirium After Cardiac Surgery NCT04194411 | Yonsei University | — |
| Completed | Effect of Cerebral Oxygen Saturation Intervention NCT04212988 | First Affiliated Hospital Xi'an Jiaotong University | N/A |
| Unknown | Blood Sugar Level and Postoperative Agitations in Pediatric Surgery NCT04193280 | Istanbul Medeniyet University | — |
| Completed | Preoperative Anxiety and Preemptive Analgesia on Postoperative Delirium in Adenotonsillectomy Surgery NCT05802082 | Zonguldak Bulent Ecevit University | — |
| Completed | Validation of the Greek Version of the Confusion Assessment Method Diagnostic Algorithm (CAM) and the Nursing NCT04154176 | University of Thessaly | — |
| Completed | Different Frailty Scores to Incidence of Post-operative Delirium and Cognitive Dysfunction NCT04056871 | University of Malaya | — |
| Unknown | The Efficacy and Safety of Tropisetron in Preventing Emergence Delirium NCT04027751 | Beijing Chao Yang Hospital | Phase 4 |
| Unknown | Predicting Cognition After DBS for Parkinson's Disease NCT03982953 | Charite University, Berlin, Germany | — |
| Unknown | Biochemical Predictors of Delirium in Cardiac Surgery NCT03931499 | Meshalkin Research Institute of Pathology of Circulation | — |
| Unknown | Correlation Between Plasma Oxidized Low Density Lipoprotein Levels And Postoperative Delirium NCT03968887 | Second Affiliated Hospital, School of Medicine, Zhejiang University | — |
| Completed | Predicting Postoperative Delirium Using EEG, Genetics and Neurobiomarkers of Cerebral Injury NCT03706989 | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | N/A |
| Completed | Acupoint Stimulation Improve Postoperative Delirium in Elderly Patients NCT03726073 | Air Force Military Medical University, China | N/A |
| Unknown | Correlation Between Blood Biomarkers and Postoperative Delirium in Elective Non-Cardiac Surgery. NCT03915314 | Xuzhou Medical University | — |
| Completed | Emergence Agitation in Paediatric Day Care Surgery NCT06571890 | University of Southern Denmark | N/A |
| Completed | Perioperative Electroencephalography Characteristics of Postoperative Delirium in Elderly NCT03879850 | Charite University, Berlin, Germany | — |
| Completed | The Association Between SIRI and POD in Older Patients NCT05797194 | Changhai Hospital | — |
| Completed | Cognitive Outcome After Surgical and Transcatheter Aortic Valve Replacement NCT04535076 | Heart and Brain Research Group, Germany | N/A |
| Terminated | Clinical Trial With Quetiapine Prophylaxis Postoperative Delirium in High Risk Surgical Patients NCT03739476 | Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León | Phase 3 |
| Completed | Multimodal Versus Opioid aNalgesia in carDiAc Surgery NCT04987372 | University Hospital, Ghent | Phase 4 |
| Completed | Intraoperative Infusion of Methylene Blue for Prevention of Postoperative Delirium and Cognitive Dysfunction i NCT04341844 | Fudan University | N/A |
| Completed | Reduction of Intraoperative EEG Burst Suppression NCT03775356 | Technical University of Munich | N/A |
| Unknown | Evidence for Cognitive Compensation Mechanism in the Postoperative Delirium: a Prospective Multi-modal Neuroim NCT05375409 | Beijing Tiantan Hospital | — |
| Terminated | Dexmedetomidine Combined With Ropivacaine for Postoperative Continuous Femoral Nerve Block NCT03629483 | Peking University First Hospital | Phase 4 |
| Unknown | Postoperative Delirium and Its Biomarkers in Elderly Patients Undergoing Non-cardiac and Non-neurosurgery. NCT05177159 | Beijing Tiantan Hospital | — |
| Unknown | Incidence and Risk Factors of PostopeRativE Delirium in ICU in China NCT03704324 | Shanghai Zhongshan Hospital | — |
| Completed | Dexmedetomidine Supplemented Intravenous Analgesia in Elderly After Orthopedic Surgery NCT03629262 | Peking University First Hospital | Phase 4 |
| Completed | Postoperative Delirium: EEG Markers of Sleep and Wakefulness NCT03291626 | Washington University School of Medicine | — |
| Completed | Non-pharmacological Prevention of Postoperative Delirium by Occupational Therapy Teams NCT03704090 | University of Chile | N/A |
| Completed | Assessing the Incidence of Postoperative Delirium Following Aortic Valve Replacement NCT03950440 | Universitaire Ziekenhuizen KU Leuven | — |
| Completed | Effect of Electroacupuncture on the Incidence of Postoperative Delirium in Elderly Patients Undergoing the Maj NCT03606941 | Tianjin Nankai Hospital | N/A |
| Unknown | Risk Factor of POD and POCD After Cardiac Surgery NCT03635229 | Mahidol University | — |
| Unknown | the Research of the Cerebral Protection Effects of Electroencephalogram (SedLine) During Carotid Endarterectom NCT03622515 | Beijing Municipal Administration of Hospitals | N/A |
| Unknown | Propofol and Dexmedetomidine on Inflammation NCT03600727 | The First Affiliated Hospital of Anhui Medical University | N/A |
| Completed | Modulating ApoE Signalling to Reduce Brain Inflammation, deLirium and postopErative Cognitive Dysfunction NCT03802396 | Miles Berger, MD PhD | Phase 2 |
| Unknown | Automated Administration of Intravenous Compared With Inhalatory Anesthesia on the Occurrence of Postoperative NCT03705728 | Centre Clinical, France | N/A |
| Unknown | Electrical Acupoint Stimulation for Postoperative Recovery NCT03249701 | Shandong University of Traditional Chinese Medicine | N/A |
| Recruiting | Development of a Prediction Model for Delirium After Cardiac Surgery Using a Novel Self-Administered Preoperat NCT03360838 | University Hospital, Basel, Switzerland | — |
| Completed | The Effect of Preoperative Anxiety on Postoperative Delirium in Children NCT04009200 | Ankara Diskapi Training and Research Hospital | — |
| Completed | Association Between Changes of GFAP After Surgery and Postoperative Delayed Cognitive Recovery NCT03683537 | Moscow Clinical Scientific Center | — |
| Terminated | Cognitive Impairment Following Elective Spine Surgery NCT03486288 | University Medicine Greifswald | — |
| Withdrawn | Association of Haptoglobin 2-2 With Postoperative Delirium NCT03392480 | Sun Yat-sen University | — |
| Recruiting | Trajectory of Neuroinflammatory Markers in Cerebrospinal Fluid Prior to and After Thoracic Aortic Surgery NCT04523909 | Radboud University Medical Center | — |
| Terminated | Incidence and Characteristics of Postoperative Cognitive Dysfunction in Elderly Quebec Francophone Patients NCT03337282 | Ciusss de L'Est de l'Île de Montréal | — |
| Completed | EPO for Postop Delirium in Elderly Patients NCT06178835 | Yonsei University | Phase 4 |
| Unknown | Protocol for Observational Study of Post op Delirium Following Total Joint Arthroplasties NCT03260218 | Singapore General Hospital | — |
| Unknown | Postoperative Delirium After Total Knee Arthroplasty Under Regional Anesthesia NCT03120442 | Mahidol University | N/A |
| Completed | Manual vs Automated Anesthesia : Impact On The Incidence Of POCD NCT03148730 | Erasme University Hospital | N/A |
| Completed | Does Preoperative Sleep Quality Affect the Postoperative Emergence Delirium in Children Undergoing Strabismus NCT03332407 | Pusan National University Hospital | — |
| Completed | Cerebral Blood Supply During Cardiopulmonary Bypass NCT03117712 | Medical University of Vienna | — |
| Completed | Minimizing ICU Neurological Dysfunction With Dexmedetomidine-induced Sleep NCT02856594 | Massachusetts General Hospital | Phase 2 / Phase 3 |
| Completed | Carbon Dioxide Surgical Field Flooding and Aortic No-touch Off-pump Coronary Artery Bypass Grafting to Reduce NCT03074604 | Collegium Medicum w Bydgoszczy | N/A |
| Completed | fMRI Connectivity in Fracture Hip Patients NCT02997930 | University of Florida | N/A |
| Completed | Validation of the 3D-CAM to Detect Postoperative Delirium NCT02992717 | Charite University, Berlin, Germany | — |
| Completed | Frailty, Anesthesia and Complications. NCT04264351 | Fundacio Puigvert | — |
| Completed | Whether Dexmedetomidine Can Improve the Prognosis of Elderly Patients With Postoperative Cognitive Dysfunction NCT02923128 | Zhejiang Cancer Hospital | Phase 4 |
| Unknown | Effect of High vs. Low MAP Levels on Clinical Outcomes in Elderly Patients During Noncardiothoracic Surgery NCT02857153 | Hu Anmin | N/A |
| Completed | Validation Study of the Malay Version of 3D-CAM NCT03366896 | University of Malaya | N/A |
| Completed | Whether Opioids Are Factor That Induced POD? NCT05596071 | Zhejiang Cancer Hospital | N/A |
| Completed | Comparison of Postoperative Delirium in Patients Anaesthetised With Isoflurane and Desflurane During Spinal Su NCT02925611 | Post Graduate Institute of Medical Education and Research, Chandigarh | Phase 4 |
| Completed | Predictive Value of β2-microspheres for Postoperative Delirium NCT03130231 | Zhongda Hospital | — |
| Completed | Predictors of Postoperative Delirium After Transcatheter Aortic Valve Implantation NCT02585128 | Cardiocentro Ticino | N/A |
| Completed | Postoperative Delirium - European Society of Anaesthesiology Survey NCT02513537 | Charite University, Berlin, Germany | — |
| Completed | Incidence and Perioperative Factors Associated With Postoperative Delirium NCT02904928 | Makerere University | — |
| Completed | Trajectory of Recovery in the Elderly NCT02275026 | Icahn School of Medicine at Mount Sinai | N/A |
| Completed | Study of Postoperative Delirium in Elderly People After Orthopedic Surgery NCT02817386 | Zhongnan Hospital | — |
| Completed | Risk Assessment for Postoperative Delirium NCT02377115 | University Hospital, Basel, Switzerland | N/A |
| Completed | Ulinastatin Improves Post-Cardiac Surgery Cognitive Dysfunction NCT06268249 | Qin Zhang | — |
| Unknown | Factors Affecting the Incidence of Postoperative Delirium in Frail Elderly NCT02227225 | Singapore General Hospital | — |
| Unknown | An MRI Study of Post-operative Delirium in Patients Undergoing Major Surgery NCT02126215 | University of Manitoba | — |
| Completed | Study of Depressive Symptoms Predicting Postoperative Cognitive Dysfunction NCT02210312 | Universitätsklinikum Hamburg-Eppendorf | — |
| Completed | Study of Prevention of Postoperative Delirum to Reduce Incidence of Postoperative Cognitive Dysfunction NCT03060174 | Universitätsklinikum Hamburg-Eppendorf | N/A |
| Completed | Postoperative Cognitive Training to Prevent Delirium NCT06601673 | Universitätsklinikum Hamburg-Eppendorf | N/A |
| Unknown | Sevoflurane Decreases the Risk of Postoperative Delirium After Cerebral Hypoxemia During Surgery NCT02133638 | Negovsky Reanimatology Research Institute | Phase 4 |
| Unknown | Optimized Anesthesia to Reduce Incidence of Postoperative Delirium NCT02133430 | Chiang Mai University | Phase 2 / Phase 3 |
| Completed | Depth of Anaesthesia and Postoperative Cognitive Decline in Patients Undergoing Heart Surgery NCT01743456 | King's College Hospital NHS Trust | N/A |
| Completed | Incidence, Long- Term Outcome and Factor Related to Non- Cardiac Postoperative Delirium in Elderly Patients NCT02131181 | Chiang Mai University | — |
| Completed | Markers of Alzheimers Disease and Cognitive Outcomes After Perioperative Care NCT01993836 | Duke University | Phase 4 |
| Completed | Relevance of the Peripheral Cholinesterase-activity on Neurocognitive Dysfunctions in Surgical Patients NCT01964274 | Charite University, Berlin, Germany | — |
| Unknown | Postoperative Recovery in Elderly Patients Undergoing Hip Hemi-arthroplasty NCT01934049 | Chinese PLA General Hospital | Phase 4 |
| Completed | Baden Prevention and Reduction of Incidence of Postoperative Delirium Trial NCT02433041 | University Hospital, Basel, Switzerland | Phase 4 |
| Completed | Predictors for Postoperative Delirium After Cardiac Surgery in Adults: a One-year, Single Center, Observationa NCT02613845 | University Hospital, Basel, Switzerland | — |
| Completed | Pilot and Feasibility Study of a Mirrors Intervention for Reducing Delirium in Older Cardiac Surgical Patients NCT01599689 | Papworth Hospital NHS Foundation Trust | N/A |
| Completed | The Comparison of Incidence and Risk Factors of Postoperative Delirium in Elderly Patients After Lower Extremi NCT02360982 | Cukurova University | — |
| Completed | Anesthesia-analgesia Methods and Postoperative Delirium NCT01661907 | Peking University First Hospital | N/A |
| Terminated | Impact of a Multifaceted Program to Prevent Postoperative Delirium in the Elderly NCT01316965 | Hospices Civils de Lyon | N/A |
| Completed | Predictors for Postoperative Delirium After Major Noncardiac Surgery in Adults NCT04460716 | University Hospital, Basel, Switzerland | — |
| Completed | Association of Plasma Melatonin Levels With Delirium NCT01570881 | Okayama University | — |
| Completed | Perioperative Cognitive Function - Dexmedetomidine and Cognitive Reserve NCT00561678 | Icahn School of Medicine at Mount Sinai | Phase 4 |
| Terminated | Cognitive Protection - Dexmedetomidine and Cognitive Reserve NCT00455143 | Icahn School of Medicine at Mount Sinai | Phase 4 |
| Completed | Clinical Trial of Gabapentin to Decrease Postoperative Delirium and Pain NCT00221338 | University of California, San Francisco | Phase 3 |
| Completed | Postoperative Delirium at Heidelberg's Intensive Care Unit -New Diagnostic Markers NCT00463333 | Heidelberg University | — |