NCT05239897

Treatment of Postoperative Delirium With Continuous Theta Burst Stimulation

Treatment of Postoperative Delirium With Continuous Theta Burst Stimulation: an Exploratory Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: RenJi Hospital · Academic / Other
• Sex: All
• Age: 60 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

To determine whether continuous theta burst stimulation can cure postoperative delirium in senior patients.

Detailed description

Postoperative delirium(POD), a syndrome characterized by an acute change in attention, awareness and cognition, is one of the most common postoperative complications among elderly patients. Impaired neuronal network connectivity is likely one of the several neurobiological processes that contribute to POD pathogenesis. Recently, continuous theta burst stimulation (cTBS) was demonstrated to improve cognitive function in patients with mild cognitive impairment.Recent research suggests that cTBS has positive effect on improving the connectivity and reorganization of the brain network. Therefore, we plan to conduct an exploratory study in participants undergoing elective surgeries to determine whether cTBS can cure POD in this senior patient population.

Conditions

• Postoperative Delirium

Interventions

Type	Name	Description
DEVICE	Continuous theta burst stimulation (cTBS)	Patients assessed for postoperative delirium will be treated by consist of 600 pulses per session, delivered over the right dorsolateral prefrontal cortex at 80% of resting motor threshold (RMT). Every session cTBS consists of 50 Hz triplets of pulses delivered at 5 Hz for 40 seconds for a total of 600 pulses. Every set simulation includes 3 sessions.

Timeline

• Start date: 2022-02-07
• Primary completion: 2023-02-28
• Completion: 2023-03-15
• First posted: 2022-02-15
• Last updated: 2024-11-18

Locations

1 site across 1 country: China