NCT02997930

fMRI Connectivity in Fracture Hip Patients

Functional Connectivity (With fMRI) as an Objective Measure of Postoperative Cognitive Function in Elderly Fracture Hip Patients

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 2 (actual)
• Sponsor: University of Florida · Academic / Other
• Sex: All
• Age: 65 Years – 99 Years
• Healthy volunteers: Not accepted

Summary

The long-term goal of this study is to evaluate cognitive function preoperatively and develop techniques of intervention in the perioperative period which would optimize brain function and functional recovery following surgery.

Detailed description

In this protocol, subjects who are anticipated to be operated for hip fracture will be studied after surgery. Brief cognitive exam will be done followed by fMRI of connectivity and diffusion tensor imaging (DTI). Connectivity (neuronal changes) and DTI (Anisotropy and mean diffusivity) data will be compared with age matched controls and correlated with subjective measures of cognition.

Conditions

• Postoperative Delirium
• Postoperative Cognitive Dysfunction

Interventions

Type	Name	Description
BEHAVIORAL	fMRI	fMRI for measuring function connectivity and DTI will be done between day 2 to day 5.
BEHAVIORAL	Montreal Cognitive Assessment (MoCA)	A measure of general cognition
BEHAVIORAL	Digital Clock Drawing Test Command and Copy	A measure of current cognition using digital pen technology
BEHAVIORAL	Wide Range Achievement Test reading subtest	A measure of premorbid intellectual estimate
BEHAVIORAL	Hopkins Verbal Learning Test (HVLT)	A measure of declarative memory
BEHAVIORAL	General Depression Scale (GDS)	A measure of the of presence of depression.

Timeline

• Start date: 2017-01-29
• Primary completion: 2019-05-06
• Completion: 2019-05-06
• First posted: 2016-12-20
• Last updated: 2019-08-12

Locations

1 site across 1 country: United States