NCT06178835

EPO for Postop Delirium in Elderly Patients

Erythropoietin for the Prevention of Postoperative Delirium in Elderly Patients Undergoing Total Joint Arthroplasty: Randomized Controlled Study

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 76 (actual)
• Sponsor: Yonsei University · Academic / Other
• Sex: All
• Age: 65 Years
• Healthy volunteers: Not accepted

Summary

Postoperative delirium is a common complication after surgery. The underlying pathophysiology of this complication is unclear, however neuroinflammation and oxidative stress secondary to surgery had shown to be the cause of postoperative cognitive dysfunction and delirium. Erythropoietin represents non-erythropoietic effects of anti-inflammatory properties. The aims of this study were to determine the role of erythropoietin toward the development of postoperative delirium, in terms of changes in inflammatory reaction by affecting the innate immunity in elderly patients undergoing total joint arthroplasty surgery.

Conditions

• Postoperative Delirium

Interventions

Type	Name	Description
DRUG	Erythropoietin	500 IU/kg of erythropoietin is given 3 times for each patient: the day before surgery, start of surgery and on postoperative day 1.
DRUG	normal saline	The same amount of normal saline is given 3 times for each patient: the day before surgery, start of surgery and on postoperative day 1.

Timeline

• Start date: 2017-09-12
• Primary completion: 2019-07-28
• Completion: 2019-08-28
• First posted: 2023-12-21
• Last updated: 2023-12-21

Locations

1 site across 1 country: South Korea