NCT04875182

The Relationship Between Zonulin and Interleukin-8 Levels and Postoperative Delirium Development

The Relationship Between Zonulin and Interleukin-8 Levels and Postoperative Delirium Development in Patients Who Had Femur Fracture Surgery Under Regional Anesthesia

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 73 (actual)
• Sponsor: Dr. Gokhan Vural · Academic / Other
• Sex: All
• Age: 65 Years
• Healthy volunteers: Not accepted

Summary

The relationship between zonulin and interleukin-8 levels and postoperative delirium development in patients who had femur fracture surgery under regional anesthesia

Detailed description

Patients who are over 65 years of age and scheduled for femur fixation surgery will be included in the study. Blood samples for zonulin and interleukin-8 levels will be taken at the day prior to the surgery. All patients will be evaluated by the Turkish version of the Delirium Rating Scale-Revised-98 (DRS-R-98) for delirium development at the postoperative 1., 2. and 3. days. Patients with a DRS-R-98 score of 11 points or higher will be included in the Group Delirium. And second blood samples for zonulin and interleukin-8 levels will be taken at the time of diagnosis. Postoperative pain scores of the patients will recorded by using a numerical rating scale (NRS).

Conditions

• Postoperative Delirium

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Evaluation of Delirium development	Postoperative pain scores of the patients will recorded by using a numerical rating scale.

Timeline

• Start date: 2021-05-01
• Primary completion: 2021-09-02
• Completion: 2021-09-02
• First posted: 2021-05-06
• Last updated: 2025-09-24

Locations

1 site across 1 country: Turkey (Türkiye)