NCT06138340

The Effects of Anesthetics on Brain Network Connectivity in Patients With Supratentorial Glioma

The Alterations of Brain Network Connectivity Under Sedation and Anesthesia in Patients With Supratentorial Glioma

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 120 (estimated)
• Sponsor: Beijing Tiantan Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Perioperative anesthesia can affect postoperative cognitive function. In our previous study, intraoperative dexmedetomidine (Dex) infusion reduced the incidence of delirium within the first 5 days after brain tumor. However, the mechanism is still unclear. With the development of neuroimaging, multimodal neuroimaging technology provide a new method to explore the underlying mechanism. Therefore, the purpose of this study is to analyze the alterations of brain network under sedation and anesthesia by different anesthetics in patients with supratentorial glioma and their association with cognition.

Conditions

• Brain Network Connectivity
• Postoperative Delirium
• Dexmedetomidine
• Propofol

Interventions

Type	Name	Description
DRUG	Dexmedetomidine	Participants will be sedated and maintained by dexmedetomidine during the surgery.
DRUG	Propofol	Participants will be sedated and maintained by propofol during the surgery.
DRUG	Remimazolam Injection	Participants will be sedated and maintained by remimazolam during the surgery.

Timeline

• Start date: 2023-08-31
• Primary completion: 2025-11-30
• Completion: 2025-12-31
• First posted: 2023-11-18
• Last updated: 2025-02-14

Locations

1 site across 1 country: China