NCT02817386

Study of Postoperative Delirium in Elderly People After Orthopedic Surgery

microRNA and Delirium After Hip and Knee Fracture

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 52 (actual)
• Sponsor: Zhongnan Hospital · Academic / Other
• Sex: All
• Age: 65 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to investigate the possible relationship of microRNA and postoperative delirium.

Detailed description

Postoperative delirium is one of the most common postoperative complications in elderly patients.It has been shown that postoperative delirium has independent adverse effects on short and long-term mortality and morbidity, including poor functional recovery, postoperative cognitive dysfunction, deterioration in quality of life, and increased costs. However, at the present time, postoperative delirium is a clinical phenomenon, and its neuropathogenesis remains unknown. This gap in knowledge has become a barrier that limits further studies, including the development of potential interventions for postoperative delirium.

Conditions

• Postoperative Delirium

Interventions

Type	Name	Description
OTHER	interview	Trained clinical research assistants interviewed the patients on the first and second day post surgery. The interview included the Confusion Assessment Method (CAM) and MDAS. CAM is a diagnostic algorithm used to determine the presence or absence of delirium.

Timeline

• Start date: 2015-03-01
• Primary completion: 2016-01-01
• Completion: 2016-02-01
• First posted: 2016-06-29
• Last updated: 2017-02-24