NCT04541823

The Effect of Desflurane on Postopertative Cognitive Dysfunction

A Study Evaluating the Effect of Desflurane in Preventing Postoperative Cognitive Dysfunction

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: Beijing Chao Yang Hospital · Academic / Other
• Sex: All
• Age: 65 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine the effect of desflurane on postoperative cognitive dysfunction

Detailed description

Postoperative cognitive dysfunction is a common complication during postoperative period，especially in elderly patients. It is characterized by cognitive decline, inattention and abnormal mental status following surgery. The presence of postoperative cognitive dysfunction is independently associated with poor recovery, increased hospital length of stay and increased mortality. Desflurane is a widely used volatile anesthetic, associated with shorter emergence times than other volatile anesthetics. This study aims to access the effect of desflurane in preventing postoperative cognitive dysfunction.

Conditions

• Postoperative Cognitive Dysfunction
• Postoperative Delirium

Interventions

Type	Name	Description
DRUG	Desflurane	Investigators administrated desflurane with target of BIS 40-60 during the maintenance of anesthesia
DRUG	Propofol	Investigators administrated propofol with target of BIS 40-60 during the maintenance of anesthesia

Timeline

• Start date: 2021-05-01
• Primary completion: 2022-12-01
• Completion: 2023-03-01
• First posted: 2020-09-09
• Last updated: 2021-08-19

Locations

1 site across 1 country: China