NCT02133430

Optimized Anesthesia to Reduce Incidence of Postoperative Delirium

Optimized Anesthesia to Reduce Incidence of Postoperative Delirium in Elderly Undergoing Elective, Non-cardiac Surgery: a Randomized Controlled Trial (POD-II)

• Status: Unknown
• Phase: Phase 2 / Phase 3
• Study type: Interventional
• Enrollment: 140 (estimated)
• Sponsor: Chiang Mai University · Academic / Other
• Sex: All
• Age: 65 Years – 95 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to compare the difference of incidence of postoperative delirium between patients received general anesthesia guided by Bispectral index (BIS) and patients received general anesthesia using standard technique.

Detailed description

General anesthesia is one of precipitating factor of postoperative delirium which Its mechanism is still unknown. General anesthesia can affect on pattern of electroencephalograph. Previous studies showed that patients received BIS guided anesthesia could wake up faster, earlier extubation and stay in recovery room shorter compared to standard general anesthesia. Optimized level of anesthesia by BIS could reduce cognitive dysfunction in elderly patients and reduce biological marker of brain injury. Therefore, the investigators hypothesized that adjustment of general anesthesia by BIS guided could protect central nervous system and reduce incidence of postoperative delirium.

Conditions

• Postoperative Delirium

Interventions

Type	Name	Description
DEVICE	Bispectral index, as measured by a BIS processor	Comparisons of incidence of postoperative delirium.

Timeline

• Start date: 2014-01-01
• Primary completion: 2015-02-01
• Completion: 2015-04-01
• First posted: 2014-05-08
• Last updated: 2014-05-12

Locations

1 site across 1 country: Thailand