NCT07323485

Inflammatory Biomarkers and Postoperative Delirium in Pediatric Circumcision

Effect of Preoperative Inflammatory Biomarkers on Postoperative Delirium in Children Undergoing Circumcision

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 140 (estimated)
• Sponsor: Ankara Etlik City Hospital · Other Government
• Sex: Male
• Age: 2 Years – 12 Years
• Healthy volunteers: Accepted

Summary

Postoperative delirium may occur in children after general anesthesia, even following short procedures such as circumcision. Preoperative systemic inflammation has been associated with postoperative delirium in adults, but data in pediatric patients are limited. This prospective observational study aims to evaluate the association between preoperative inflammatory biomarkers and postoperative delirium in children aged 2-12 years undergoing elective circumcision under general anesthesia. Inflammatory biomarkers derived from routine complete blood count parameters, including NLR, PLR, MLR, SII, and SIRI, will be analyzed. Postoperative delirium will be assessed using the Pediatric Anesthesia Emergence Delirium (PAED) scale in the post-anesthesia care unit. The relationship between inflammatory biomarkers and delirium development and severity will be evaluated. This study seeks to identify simple preoperative markers that may help predict postoperative delirium risk in pediatric patients.

Conditions

• Postoperative Delirium
• Pediatric Anesthesia
• Inflammatory Biomarkers

Interventions

Type	Name	Description
OTHER	Measurement of Preoperative Inflammatory Biomarkers	Blood samples will be collected preoperatively to assess inflammatory biomarkers, including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), monocyte-to-lymphocyte ratio (MLR), and the systemic inflammation response index (SIRI). These parameters will be analyzed in relation to the incidence of emergence delirium within the first 2 hours following pediatric circumcision. No experimental drug or medical device will be used as part of the study; all procedures will be performed within the scope of standard perioperative care.

Timeline

• Start date: 2026-01-18
• Primary completion: 2026-06-10
• Completion: 2026-07-25
• First posted: 2026-01-07
• Last updated: 2026-02-20

Locations

1 site across 1 country: Turkey (Türkiye)