NCT05368272

EEG Spectrogram, Brain Vulnerability and POD

EEG Spectrogram to Assess Brain Vulnerability as a Risk Factor for Postoperative Delirium in Older People - a Feasibility Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 30 (actual)
• Sponsor: University of Nottingham · Academic / Other
• Sex: All
• Age: 65 Years
• Healthy volunteers: Not accepted

Summary

An assessment of difference in prespecified processed electroencephalography variables between cognitively intact older surgical patients who develop postoperative delirium compared to those who do not develop postoperative delirium

Detailed description

Postoperative delirium in older people may be contributed to by intrinsic brain vulnerability such as pre-existing dementia. Some cognitively intact older people also experience postoperative delirium and in these patients some go on to develop later dementia. The investigators propose that postoperative delirium may be an unmasking of covert brain vulnerability by the dyshomeostasis of the anaesthesia/surgical intervention. In people with dementia or mild cognitive impairment, electroencephalography (EEG) studies have shown slowing of brain wave activity, especially in the back of the brain. Processed electroencephalography, using a limited number of channels, is routinely used during anaesthesia to aid assessment of anaesthetic depth of the patient. In this study the investigators will assess the feasibility of acquiring EEG data from the front and back of the brain. The investigators will also explore the data for early signals of brain vulnerability

Conditions

• Postoperative Delirium

Interventions

Type	Name	Description
OTHER	Processed electroencephalography	Acquisition of raw EEG data from processed EEG monitor. Analysis of data acquired for prespecified bandwidth properties
OTHER	Postoperative delirium assessment	Twice daily assessment for the incidence of postoperative delirium using validated tool (questionnaire)

Timeline

• Start date: 2023-01-27
• Primary completion: 2023-12-06
• Completion: 2023-12-06
• First posted: 2022-05-10
• Last updated: 2024-02-28

Locations

1 site across 1 country: United Kingdom