NCT01993836

Markers of Alzheimers Disease and Cognitive Outcomes After Perioperative Care

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 191 (actual)
• Sponsor: Duke University · Academic / Other
• Sex: All
• Age: 60 Years
• Healthy volunteers: Not accepted

Summary

This study will examine the hypothesis that changes in the cognition (i.e. thinking and memory) after anesthesia and surgery are correlated with changes in markers of Alzheimers Disease in the fluid around the brain and spinal cord (i.e. cerebrospinal fluid, or CSF), and/or changes in brain connectivity. The investigators will also examine whether different types of anesthesia have different effects on these CSF markers of Alzheimers disease, or different effects on thinking and memory after anesthesia and surgery, or differential effects on the correlation between cognitive changes and CSF marker changes.

Conditions

• Alzheimers Disease
• Postoperative Delirium
• Post Operative Cognitive Dysfunction

Interventions

Type	Name	Description
DRUG	Total intravenous anesthesia with propofol
DRUG	General anesthesia with isoflurane

Timeline

• Start date: 2013-11-01
• Primary completion: 2019-01-10
• Completion: 2019-01-10
• First posted: 2013-11-25
• Last updated: 2023-03-22
• Results posted: 2020-05-05

Locations

1 site across 1 country: United States