NCT07411794

Dexmedetomidine vs Midazolam in Coronary Artery By-pass Surgery

A Comparative Evaluation of Dexmedetomidine and Midazolam ınfusions With Respect to Postoperative Delirium in Patients Undergoing Coronary Artery Bypass Grafting

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Cumhuriyet University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The aim is to compare the incidence of postoperative delirium following coronary artery bypass grafting (CABG) between patients receiving dexmedetomidine and those receiving midazolam infusions.

Detailed description

Patients will be allocated into two groups. Those receiving intraoperative dexmedetomidine infusion will constitute Group D (n = 30), while those receiving intraoperative midazolam infusion will constitute Group M (n = 30). Demographic data, including age, sex, and body mass index, will be recorded. Intraoperative heart rate, mean arterial pressure, SpO₂, bispectral index (BIS), and cerebral oxygenation values will be documented at predetermined intervals. Changes in pCO₂ levels will also be recorded. Surgical duration, cardiopulmonary bypass time, recovery time, length of intensive care unit stay, and the presence of delirium as assessed by the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) will be documented.

Conditions

• Postoperative Delirium

Interventions

Type	Name	Description
DRUG	Intravenous Dexmedetomidine infusion + Standard Anesthesia	Following the induction of standard general anaesthesia, dexmedetomidine will be administered as a continuous intravenous infusion at a dose of 0.3-0.7 µg/kg/h.
DRUG	intravenous midazolam infusion + Standard anesthesia	Following the induction of standard general anaesthesia, midazolam will be administered as a continuous intravenous infusion at a dose of 0.03-0.06 mg/kg/h.

Timeline

• Start date: 2026-01-15
• Primary completion: 2026-06-01
• Completion: 2026-06-15
• First posted: 2026-02-17
• Last updated: 2026-02-17

Locations

1 site across 1 country: Turkey (Türkiye)