Major Depression

279 registered clinical trials studyying Major Depression — 24 currently recruiting.

Status	Trial	Sponsor	Phase
Not Yet Recruiting	Shortened LSD Intervention for Major Depressive Disorder NCT07503002	Johns Hopkins University	Phase 1
Not Yet Recruiting	Anesthesia-Masked Psilocybin Therapy for Major Depression NCT07479550	Stanford University	Phase 2
Not Yet Recruiting	Psilocybin Intervention for Veterans Overcoming Treatment-Resistant Depression NCT07226232	VA Office of Research and Development	Phase 3
Not Yet Recruiting	Modular Intervention for Depression Study NCT07380451	Pontificia Universidad Catolica de Chile	N/A
Recruiting	Accelerated High-Dose tDCS for Depression NCT07226011	Medical University of South Carolina	N/A
Withdrawn	Lifestyle MIND- Feasibility of Wait-list Control NCT06384521	The University of Texas Health Science Center at San Antonio	N/A
Recruiting	Study of Sleep Inertia in Major Depressive Disorder by the Psychomotor Vigilance Task NCT06732284	Centre Hospitalier Universitaire de Nīmes	—
Recruiting	Validation of a Composite Medical Device Using a Blood Biomarker-based Algorithm and MDQ for the Diagnosis of NCT07031817	University Hospital, Montpellier	N/A
Active Not Recruiting	Efficacy and Safety of Task-specific, Biomarker-driven, HD-ctACS inTRD. NCT07184697	Ruijin Hospital	N/A
Not Yet Recruiting	A Randomized Control Trial of Enhanced Cognitive Behavioural Group Therapy for Older Adults with Depression: E NCT06894641	Nova Scotia Health Authority	N/A
Completed	The Brain-Heart-Gut Connection NCT06748274	University of Bern	N/A
Active Not Recruiting	Treatment Response In ECT Patients NCT07463911	Nurdan Sağbaş	—
Completed	Sleep TMS for Depression NCT06824415	Stanford University	N/A
Recruiting	Pharmacogenomics of Selective Serotonin Reuptake Inhibitor (SSRI)-Induced Behavioural Activation NCT06763081	University of Manitoba	—
Not Yet Recruiting	MonPsy&Moi: A Digital Platform for Collecting Patient-Reported Experience and Outcome Measures in Psychiatry NCT06818227	Assistance Publique Hopitaux De Marseille	—
Not Yet Recruiting	Transcranial Magnetic Stimulation in Patients with Dual Disorders NCT06765824	Cardenal Herrera University	Phase 3
Recruiting	Leucine in Midlife Depression NCT06580145	Emory University	Phase 2
Withdrawn	Common Factors Group Psychotherapy for General Mental Health Concerns NCT06614842	University of Alabama at Birmingham	N/A
Recruiting	Combining Light Therapy and CPAP in Depression NCT06781593	Hôpital le Vinatier	N/A
Recruiting	Effect of Aerobic Exercise on Biomarkers in Depression NCT07062783	Kutahya Health Sciences University	N/A
Terminated	Combining rTMS and tDCS in Depression: an Exploratory Clinical Trial NCT06500533	Regionspsykiatrien Gødstrup	N/A
Recruiting	Added Value of a Neuroendocrine Test Battery in the Response to Repetitive Transcranial Magnetic Stimulation ( NCT05964192	Centre Hospitalier Rouffach	N/A
Recruiting	NIMH Rhythms and Blues Study: A Prospective Natural History Study of Motor Activity, Mood States, and Bipolar NCT05669703	National Institute of Mental Health (NIMH)	—
Unknown	Open-Label Dose-Ranging Study of Oral SM-001 in Healthy Adults NCT05894902	Advanced Integrative Medical Science Institute	Phase 1
Unknown	pBFS Guided VS "5-cm Rule" rTMS Over DLPFC for MDD NCT05964023	Changping Laboratory	N/A
Completed	Transcranial Pulse Stimulation for Depression NCT05551585	The Hong Kong Polytechnic University	N/A
Enrolling By Invitation	Effectiveness of mHealth Post-discharge Intervention for Patients With Severe Mental Illness NCT05703412	Butler Hospital	N/A
Unknown	AI-based Multi-center Research on Identification/Classification/Aided Diagnosis of Mood Disorder NCT05608135	First Affiliated Hospital of Zhejiang University	—
Recruiting	Interpersonal Psychotherapy for Adolescents and Young Adults NCT05575960	Linnaeus University	N/A
Unknown	TBS Over DLPFC in Elderly Refractory Depression NCT04872465	Kaohsiung Veterans General Hospital.	N/A
Completed	Non-interventional, Retrospective Cohort Study to Explore Antidepressant Treatment in Korea NCT04446039	Pfizer	—
Completed	High-Frequency vs. Theta-Burst TMS for Depression NCT07181226	Krajská zdravotní, a.s. - Nemocnice Most, o.z.	N/A
Completed	Acupoint Thermal Radiation Characteristics in Adolescents with MDD NCT06750640	Xiaomei Shao	—
Unknown	Clinical Effectiveness of Choline Alphoscerate for Older Adults With Major Depression and Subjective Memory Co NCT05257902	Samsung Medical Center	N/A
Unknown	Neuroimaging Sleep and Mood in Depression NCT05497414	Boston University Charles River Campus	N/A
Recruiting	RCT of At-Home tDCS for Depression in Pregnancy NCT05097586	Women's College Hospital	N/A
Unknown	Online System for Identifying and Addressing Teen Depression in Primary Care NCT04489485	Total Child Health, Inc.	—
Completed	Effects of Vitamin D Supplementation on Depression and Inflammatory Markers NCT04898725	Mackay Memorial Hospital	N/A
Completed	Stress Management and Resiliency Training for Depression vs Treatment as Usual in the Treatment of Major Depre NCT04388748	Mayo Clinic	N/A
Completed	Implementation of Harmonized Depression Outcome Measures in a Health System NCT04235712	OM1, Inc.	—
Completed	RCT Study on the Therapeutic Effect of Escitalopram Loaded With XingpiJieyu Formula on Resting State EEG Energ NCT06758167	Peking University Sixth Hospital	N/A
Recruiting	University of Iowa Interventional Psychiatry Service Patient Registry NCT04480918	Mark Niciu	—
Completed	Bupropion Versus Escitalopram on Reward Circuitry and Motivational Deficits NCT04352101	Emory University	Phase 4
Withdrawn	Using EEG to Predict Depression Treatment Response to rTMS in Patients With Major Depression NCT04575285	Baptist Health South Florida	—
Completed	Implementation of Harmonized Depression Outcome Measures in a Primary Care Registry and a Mental Health Regist NCT04235725	OM1, Inc.	—
Recruiting	Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With NCT03973268	National Institute of Mental Health (NIMH)	Phase 1
Completed	Walking for Health: an Intervention to Increase Physical Activity and Reduce Sedentary Behaviour in People Wit NCT04134871	University of Ulster	N/A
Completed	Online Writing Intervention for Major Depressive Disorder NCT06699719	Centre for Addiction and Mental Health	N/A
Unknown	Prediction of SSRI Treatment in Major Depression. NCT03670823	ElMindA Ltd	—
Completed	ESTIA: Computerized Intervention Targeting Cognitive Control Deficits in Depressed Adults NCT02891564	University of Washington	N/A
Completed	Technology Enhanced Family Treatment NCT03913013	University of California, Los Angeles	Phase 1 / Phase 2
Unknown	Infiltrations of OnaBotulinum Toxin A in Resistant Depression: Comparison of Two Facial Injection Sites. NCT03484754	Centre Hospitalier Esquirol	N/A
Unknown	iCare4Depression: Effectiveness of a Blended Cognitive-Behavioral Therapy in Routine Practice NCT03623724	University Institute of Maia	N/A
Withdrawn	Assessment of Hedonic and Motivational States in Major Depression ( MOODDIS) NCT03060967	Institut National de la Santé Et de la Recherche Médicale, France	N/A
Terminated	Pattern Separation, Brain Derived Neurotrophic Factors, and Mechanisms of Vortioxetine NCT02969876	Massachusetts General Hospital	Phase 4
Completed	PRIME Care (PRecision Medicine In MEntal Health Care) NCT03170362	VA Office of Research and Development	N/A
Completed	The BIO-K Study: A Single-Arm, Open-Label, Biomarker Development Clinical Trial of Ketamine for Non-Psychotic NCT03156504	Mayo Clinic	Phase 4
Terminated	Procedures for Sample Acquisition and Distribution for The Human Brain Collection Core NCT03092687	National Institute of Mental Health (NIMH)	—
Completed	Prevention of PTSD III: Neurocognitive Training of Emotional Regulation NCT02085512	NYU Langone Health	N/A
Completed	Comparing Thinking Skills for Work (TSW)Home Practice Program With Traditional TSW Program NCT03005574	Boston University Charles River Campus	N/A
Completed	Internet-Delivered Cognitive Behavior Therapy for Anxiety and Depression Amongst French Canadians NCT03043833	Universite de Moncton	N/A
Completed	A Study to Evaluate SAGE-217 in Participants With Moderate to Severe Major Depressive Disorder NCT03000530	Biogen	Phase 2
Completed	Pilot BA Study of New LY03005 vs Pristiq NCT02988024	Luye Pharma Group Ltd.	Phase 1
Completed	CBT for Anxiety Sensitivity vs. Disorder-specific CBT: An RCT NCT03015285	Nova Scotia Health Authority	N/A
Completed	Conventional Bilateral rTMS vs. Bilateral Theta Burst Stimulation for Late-Life Depression NCT02998580	Centre for Addiction and Mental Health	N/A
Unknown	Remote Cognitive Remediation for Depression NCT03492203	Queen's University	N/A
Terminated	Escitalopram Plus PS128 vs. Escitalopram NCT04093960	Kaohsiung Kai-Suan Psychiatric Hospital	Phase 4
Withdrawn	Vortioxetine for the Treatment of Major Depression and Co-morbidities After Traumatic Brain Injury (TBI) NCT02845349	Johns Hopkins University	Phase 3
Completed	Mineralocorticoid Receptor, NMDA Receptor and Cognitive Function in Depression NCT03062150	Charite University, Berlin, Germany	N/A
Completed	Blood Biomarkers in Suicidal Behaviour NCT02855918	University Hospital, Montpellier	N/A
Unknown	Effects of tDCS on Cognitive Control and Emotion Regulation in Depressed Patients NCT03039387	University Hospital Tuebingen	N/A
Unknown	Dorsomedial rTMS For Depression In Borderline Personality Disorder NCT03472638	University Health Network, Toronto	N/A
Unknown	Epidural Stimulation for Resistant Depression Treatment NCT02622633	University of Brasilia	Phase 2
Terminated	Bupropion for Depression in ESRD Patients on Hemodialysis NCT02238977	University of Arkansas	Phase 4
Completed	Home-Administered Trial of Direct Current Stimulation NCT02894736	The University of New South Wales	N/A
Completed	Psychotherapy Plus: Combining Cognitive Behavioral Therapy With tDCS NCT02633449	Charite University, Berlin, Germany	N/A
Unknown	Impact of Immune Challenge on Triple Network Connectivity in Humans NCT02653235	NHS Greater Glasgow and Clyde	N/A
Completed	Proactive Psychiatry Consultation for Patients With Cancer and Severe Mental Illness NCT02594696	Massachusetts General Hospital	N/A
Completed	A Family-based Primary Care Intervention to Enhance Older Men's Depression Care NCT02143024	University of California, Davis	N/A
Completed	Antidepressant Effects of the Glycine Receptor Antagonist AV-101 (4-chlorokynurenine) in Major Depressive Diso NCT02484456	National Institute of Mental Health (NIMH)	Phase 2
Completed	Restoring Emotion Regulation Networks in Depression Vulnerability NCT02931487	University of Oslo	N/A
Unknown	Predictors of the Outcome of Late Life Depression NCT02441387	University of Sao Paulo General Hospital	—
Completed	Secondary Prevention of Depression Through Group-based ACT-Therapy Preceded by an Experimental ABM-Procedure NCT02648165	Sorlandet Hospital HF	N/A
Completed	Psychotherapeutic Text Messaging for Depression Pilot Study NCT02872454	University of Michigan	N/A
Recruiting	Characterizing Cognitive Decline in Late Life Depression: The ADNI Depression Project NCT02434393	University of Southern California	—
Unknown	Retinoic Acid Homeostasis in Neuropsychiatric Diseases NCT02439099	Charite University, Berlin, Germany	—
Completed	Effects of ECT on Monoamine Oxidase A in Depression Investigated With PET NCT02379767	Medical University of Vienna	—
Completed	Secondary Prevention of Depression Applying an Experimental Attentional Bias Modification Procedure NCT02658682	University of Oslo	N/A
Completed	The Process Outcome Mindfulness Effects in Trainees (PrOMET)-Study NCT02270073	Heidelberg University	N/A
Completed	Person-Centered Versus Measurement-Based Care in Mental Health NCT02507349	University of Pittsburgh	N/A
Completed	A Pilot, Proof-of-concept Cohort Study of the Prevalence of Comorbid Mental Illness and Substance Abuse NCT02476877	Advanced Clinical Laboratory Solutions, Inc.	—
Completed	Comparing Engage to PST for Late Life Depression NCT02086201	University of Washington	N/A
Recruiting	Ketamine Alcohol (in Treatment-Resistant Depression) NCT02122562	Mark Niciu	Phase 2
Recruiting	Skills for Wellness NCT01980147	Nova Scotia Health Authority	N/A
Completed	The Brain on Whole Body Hyperthermia: A Neuroimaging Study NCT02062840	University of Arizona	N/A
Completed	Measurement-based Care for Depression in Resource-Poor Settings NCT02916238	Florida International University	Phase 4
Completed	Antidepressant Effects of Ayahuasca: a Randomized Placebo Controlled Trial in Treatment Resistant Depression NCT02914769	Universidade Federal do Rio Grande do Norte	Phase 1 / Phase 2
Completed	Wake and Light Therapy to In-patients With Major Depression: Efficacy, Predictors and Patient Experiences NCT02047968	University of Aarhus	N/A
Completed	iCBT for Depression - Standard Versus Condensed Treatment Material NCT01788657	Örebro County Council	N/A
Terminated	Family Based Treatment of Depressed Adolescents (AHUS) NCT01830088	University Hospital, Akershus	N/A
Completed	Vitamin D, SSRIs and the Musculoskeletal System NCT01932931	Aalborg University	N/A
Unknown	Effectiveness of Repetitive Transcranial Magnetic Stimulation in Depressed Patients NCT02213016	Universidad Nacional Autonoma de Mexico	Phase 4
Completed	Deep Brain Stimulation of the Superolateral Branch of the Medial Forebrain Bundle (slMFB) for the Treatment of NCT01778790	University Hospital, Bonn	Phase 2
Unknown	Functional Brain Imaging Study of Response to Repetitive TMS (rTMS) Treatment of Major Depression NCT01768052	Mclean Hospital	—
Completed	Get Moving and Get Well - Pilot Study NCT01884025	VA Office of Research and Development	N/A
Completed	Brain Inflammation in Major Depressive Disorder Background NCT01851356	National Institute of Mental Health (NIMH)	—
Completed	Multicenter Comparative Study of the Activity of the Medial Prefrontal Cortex in Vulnerability to Depression NCT02171923	Assistance Publique - Hôpitaux de Paris	—
Completed	Comparison of Venlafaxine and Fluoxetine in the Treatment of Postmenopausal Women With Major Depression NCT01824433	Capital Medical University	Phase 4
Terminated	Omega 3 FA Supplements as Augmentation in the Treatment of Depression NCT01803711	UConn Health	Phase 2 / Phase 3
Completed	New Clinical Applications for Internet-based Cognitive Behavior Therapy for Insomnia and Depression NCT01663844	Karolinska Institutet	N/A
Completed	Transcranial Electrical Stimulation (TES) for the Treatment of Depression. NCT01792414	The University of New South Wales	N/A
Completed	Self Focus in Bipolar Disorder: A Functional Magnetic Resonance Imaging (fMRI) Study NCT02253225	Massachusetts General Hospital	—
Completed	My Coach Connect: An Automated Telephone-based Reporting System for Patients With Mental Illness NCT01749124	RAND	N/A
Completed	Effectiveness Study of Mirtazapine Combined With Paroxetine in Major Depressive Patients Without Early Improve NCT01458626	Capital Medical University	Phase 4
Completed	Understanding How Cognitive Remediation Works NCT01683539	Boston University Charles River Campus	N/A
Completed	CBT Versus a Return to Work Intervention for Patients With Common Mental Illness in Primary Care NCT01636791	Karolinska Institutet	Phase 3
Completed	CBT vs RTW Intervention for Patients With Common Subclinical Mental Illness in Primary Care NCT01667809	Karolinska Institutet	Phase 3
Completed	Cognitive Behavioral Therapy, Guided Self Help Versus Individual Therapy NCT01667822	Karolinska Institutet	Phase 3
Completed	Microbiomes of Pelvic Pain NCT01738464	Northwestern University	—
Completed	Depression in the Elderly and Cerebral Amyloid Plaques: Characterization by [18F] AV-45 Affectives Symptoms an NCT01962753	University Hospital, Tours	N/A
Completed	PTSD (PostTraumatic Stress Disorder) Services for Veterans With SMI (Severe Mental Illness) NCT01542229	VA Office of Research and Development	N/A
Completed	Behavior During Experimentally Induced Pain NCT01594528	Centre Hospitalier Esquirol	N/A
Completed	Past Pain Experience and Perception of Experimental Pain NCT01575912	Centre Hospitalier Esquirol	—
Completed	Depression Agency-Based Collaboration NCT01566318	University of Pittsburgh	N/A
Completed	Chicago Urban Resiliency Building (CURB) NCT01571011	Benjamin Van Voorhees, MD, MPH	N/A
Completed	Effects of Sevoflurane and Ketamine on QT in Electroconvulsive Therapy NCT01870219	Inonu University	Phase 4
Completed	Primary Care Internet Based Depression Prevention for Adolescents (CATCH-IT) Also Known as Promoting Adolescen NCT01893749	Benjamin Van Voorhees, MD, MPH	N/A
Completed	Differentiating Unipolar and Bipolar Depression in Young Adults Using fMRI NCT01811147	The Cleveland Clinic	Phase 4
Unknown	Effect of Antidepressants on White Matter Structure NCT01492621	Centre de Recherche de l'Institut Universitaire en santé Mentale de Montréal	Phase 4
Unknown	Optimizing Antidepressant Treatment by Genotype-dependent Adjustment of Medication According to the ABCB1 Gene NCT02237937	HolsboerMaschmeyer NeuroChemie GmbH	Phase 4
Completed	A Working Memory Training to Decrease Rumination in Depressed and Anxious Individuals NCT02119975	Erasmus Medical Center	N/A
Terminated	Event Related Potentials in Borderline Personality Disorder and Major Depression NCT01469663	State University of New York - Upstate Medical University	—
Unknown	Inflammatory Markers and Cognitive Function in Major Depression NCT01391221	Centre de Recherche de l'Institut Universitaire en santé Mentale de Montréal	Phase 4
Completed	Healthy Mood Internet Intervention Research Project NCT01358487	University of California, San Francisco	N/A
Completed	Modulation of Cognitive Control by Transcranial Direct Current Stimulation NCT01652391	University Hospital Tuebingen	N/A
Completed	Peer Support for Severe Mental Disorders NCT02276469	Universitätsklinikum Hamburg-Eppendorf	N/A
Completed	Effects of Deep Brain Stimulation in Treatment Resistant Major Depression NCT01095263	University Hospital, Bonn	Phase 1
Completed	Trial of Transcranial Direct Current Stimulation (tDCS) NCT01346306	The University of New South Wales	N/A
Completed	Tackling Depression and Anxiety: A Working Memory Intervention NCT02119923	Erasmus Medical Center	N/A
Completed	Cognitive Behavioral Treatments for Depression in Chronic Illness NCT01208428	Duke University	N/A
Completed	Study of the Effectiveness of Vestibular Stimulation as a Coadjuvant Treatment in Major Depression NCT01399671	Fuerza Aérea de Chile	N/A
Withdrawn	Imaging Serotonin 5HT1A Receptors in Patients With Major Depressive Disorder NCT01313403	National Institute of Mental Health (NIMH)	N/A
Unknown	Efficacy Study of Botox for Depression NCT01556971	Capital Clinical Research Associates, LLC	Phase 4
Completed	Trial of Transcranial Direct Current Stimulation (tDCS) for Depression NCT01263275	The University of New South Wales	Phase 2
Unknown	Mindfulness and Lifestyle Interventions for Depression and Anxiety: A Pilot Study NCT01230047	Arizona State University	N/A
Completed	Open Pilot Trial of TES for Depression NCT01201148	The University of New South Wales	Phase 2
Completed	Efficacy and Safety Curcumin in Depression NCT01750359	Vladimir Lerner	Phase 4
Terminated	Efficacy and Safety of Homeopathy for Moderate Depression (Acute Phase) NCT01178255	Charite University, Berlin, Germany	Phase 3
Completed	My Depression Wellness Toolkit Study NCT01178424	Centre for Addiction and Mental Health	N/A
Terminated	Study of Depression-Ketamine-Brain Function NCT01135758	Markus KOSEL	Phase 2
Completed	Depression Management Project NCT01150604	University of California, San Francisco	N/A
Completed	Agomelatine in Depressed Patients With Fibromyalgia NCT01731899	Universidad de Granada	—
Terminated	Safety and Pharmacology Study of BMS-866949 NCT01124344	Bristol-Myers Squibb	Phase 1
Completed	PET Whole Body Distribution Studies Using [11C]CUMI NCT01132872	National Institute of Mental Health (NIMH)	—
Completed	Motivational Interviews for Depression in Primary Care NCT01114334	Denver Health and Hospital Authority	N/A
Terminated	Use of Ketamine to Enhance Electroconvulsive Therapy (ECT) in Depression NCT01309581	James Murrough	N/A
Completed	Lexapro for the Treatment of Traumatic Brain Injury (TBI) Depression & Other Psychiatric Conditions NCT01368432	Johns Hopkins University	Phase 2
Completed	Long-term Bilateral Theta Burst Stimulation for the Treatment of Major Depression NCT01153139	University Hospital Tuebingen	Phase 2 / Phase 3
Completed	Computerized Information-Processing Bias Retraining in Depressed Adolescents NCT01147913	Massachusetts General Hospital	Phase 2
Unknown	Neuropattern - Assessment of a Translational Diagnostic Tool for Depression, Adjustment- and Somatoform-disord NCT01062880	University of Trier	N/A
Completed	A Trial Evaluating the Efficacy and Tolerability of SSR125543 in Outpatients With Major Depressive Disorder NCT01034995	Sanofi	Phase 2
Completed	Assessing the Impact of Self-directed Care, Within a Medicaid-funded Environment,on Participation and Communit NCT02520024	Temple University Collaborative on Community Inclusion	N/A
Completed	Individually Based Psychosocial Rehabilitation for Older People With Serious Mental Illness (SMI) NCT00817154	Dartmouth-Hitchcock Medical Center	Phase 1
Completed	Trial of Transcranial Direct Current Stimulation (tDCS) Using Alternative Electrode Montages NCT01021709	The University of New South Wales	Phase 2
Completed	Interpersonal Therapy for Depression in Breast Cancer NCT01191580	New York State Psychiatric Institute	Phase 4
Completed	Ostrobothnia Depression Study (ODS). A Naturalistic Follow-up Study on Depression and Related Substance Use Di NCT02520271	Seinajoki Central Hospital	N/A
Completed	Quetiapine Prolong, Escitalopram and Hypothalamic-pituitary-adrenocortical (HPA) Axis Activity in Depressed Pa NCT00953108	Ludwig-Maximilians - University of Munich	Phase 3
Terminated	Relapse Prevention With Escitalopram or Nortriptyline Following Electro-Convulsive Treatment (DUAG-7) NCT00660062	Hillerod Hospital, Denmark	Phase 4
Completed	Electroconvulsive Therapy (ECT) for Elderly Patients With Major Depression NCT01559324	Diakonhjemmet Hospital	Phase 4
Completed	Escitalopram (Lexapro) for Depression MS or ALS NCT00965497	University of South Carolina	Phase 3
Completed	Assessment of Pituitary Adenylate Cyclase Activating Polypeptide-Brain Derived Neurotrophic Factor (PACAP-BDNF NCT00944996	Tirat Carmel Mental Health Center	N/A
Completed	Changes of Functional Connectivity After rTMS in Depression NCT01325831	Yonsei University	Phase 4
Completed	N-methylglycine (Sarcosine) Treatment for Depression NCT00977353	China Medical University Hospital	Phase 2
Completed	Brain Imaging of Quetiapine Response in Anxious Depression NCT00982345	Indiana University School of Medicine	Phase 4
Completed	fMRI Study of Treatment Changes in Major Depression NCT01027559	Washington University School of Medicine	N/A
Completed	Photobiomodulation to Alter Cerebral Blood Flow and to Affect the Emotional Status of Patients With Major Depr NCT00961454	Massachusetts General Hospital	Phase 1
Completed	Open Trial of Duloxetine in Outpatients With Irritable Bowel Syndrome Symptoms and Co-Morbid Major Depression NCT01754493	New York State Psychiatric Institute	Phase 4
Terminated	The Effect of Exercise on Depressive Symptoms in Unmedicated Patients NCT00695552	University of Copenhagen	N/A
Completed	Study of the Changes in Metabolic Parameters in Patients Treated With Escitalopram for Six Months NCT00711737	Changi General Hospital	—
Terminated	Open-Label Pilot Study to Examine the Value of Substituting Quetiapine for Benzodiazepines NCT01244711	Weill Medical College of Cornell University	Phase 4
Completed	Bilateral Versus Monolateral Repetitive Transcranial Stimulation in Depression NCT00806143	Institute of Neuroscience, Florence, Italy	Phase 4
Terminated	Family Based Treatment of Depressed Adolescents NCT00700609	Helse Stavanger HF	Phase 2
Completed	A Pilot Study on Repetitive Transcranial Magnetic Stimulation (rTMS) Treatment of Bipolar Depression NCT00699218	University of California, Davis	N/A
Completed	Study of Brain Response to Emotional Pictures Using a Magnetic Resonance Imaging (fMRI) While on Escitalopram NCT00707863	Indiana University School of Medicine	Phase 4
Unknown	Efficacy Study of Escitalopram for Depression in Patients With Diabetes NCT00650897	Sheba Medical Center	Phase 4
Completed	Evaluation of a Natural Experiment to Improve Statewide Depression Care in Minnesota (MN) NCT00781703	HealthPartners Institute	N/A
Completed	Evaluation of the H-Coil Transcranial Magnetic Stimulation(TMS) Device- Augmentation for Drug Resistant Depres NCT00577070	BeerYaakov Mental Health Center	Phase 2
Completed	Cognitive Deficits in Major Depressive Disorder and Bipolar Disorder, Depressed Type: Prevalence and Improveme NCT00844974	Massachusetts General Hospital	N/A
Completed	Cortical GABA Concentrations in Insomnia NCT00765752	Yale University	—
Completed	Interpersonal Psychotherapy for Depressed Adolescents and Parents NCT00619411	New York State Psychiatric Institute	Phase 1
Completed	Serum Markers as a Bioassay for Unipolar Depression NCT00825799	Steward St. Elizabeth's Medical Center of Boston, Inc.	—
Completed	Cimicoxib for the Treatment of Major Depression (SECIM) NCT00510822	Affectis Pharmaceuticals AG	Phase 2
Terminated	Lexapro for Major Depression in Patients With Epilepsy NCT01244724	Weill Medical College of Cornell University	Phase 4
Completed	Yoga in Unipolar and Bipolar Disorders NCT00482482	Centre for Addiction and Mental Health	N/A
Completed	The Effectiveness of FMPO in Improving the Quality of Care for Persons With Severe Mental Illness. NCT00466323	US Department of Veterans Affairs	N/A
Completed	Study of Brain Response to Emotional Pictures Using a fMRI While on Duloxetine NCT00532480	Indiana University School of Medicine	Phase 4
Completed	Increasing Use of Mental Health Services NCT00605358	Weill Medical College of Cornell University	N/A
Completed	A Double Blind Sham Controlled Trial of tDCS in Treating Schizophrenia and Depression NCT00481026	Bayside Health	N/A
Completed	A Pilot Study of TMS Effects on Pain and Depression in Patients With Fibromyalgia NCT00523302	Medical University of South Carolina	N/A
Completed	Adapting Cognitive Behavioral Therapy (CBT) for Chinese Americans NCT01786746	Claremont McKenna College	N/A
Completed	Antidepressant Effects of NR2B in Major Depression NCT00472576	National Institute of Mental Health (NIMH)	Phase 1
Completed	Randomized Trial of Psychotherapy for Persistently Depressed Primary Care Patients NCT00541957	Butler Hospital	Phase 1
Completed	Evaluation of the Deep TMS H-Coil in the Treatment of Major Depression- Augmentation of Antidepressant Medicat NCT00460902	Hadassah Medical Organization	Phase 1 / Phase 2
Completed	A Study of Quetiapine Fumarate Sustained Release in Major Depression With Comorbid Fibromyalgia Syndrome NCT00675896	Dr Alexander McIntyre Inc.	Phase 4
Unknown	Antidepressant Effect of Theta-Burst rTMS NCT00515658	Rambam Health Care Campus	Phase 2
Completed	Functional Neuroimaging in Depression NCT00343070	University Hospital, Ghent	Phase 2
Completed	Investigation of Genetic Predictors of the Response to Selective Serotonin Re-uptake Inhibitors (SSRI) Treatme NCT03927950	University of Tartu	Phase 4
Completed	Research Study for Major Depressive Disorder: Investigation of Glutamate Medications NCT00419003	Baylor College of Medicine	Phase 4
Completed	Escitalopram Treatment of Major Depression in Patients With Temporal Lobe Epilepsy NCT00595699	Conrad, Erich J., M.D.	Phase 4
Completed	The Effect on Cognition of Terminating ECT Induced Seizures With Propofol NCT00616759	Loma Linda University	N/A
Completed	Duke Conte Center for the Neuroscience of Depression in Late Life NCT00576875	Duke University	—
Completed	Attachment Security as Mediator and Moderator of Outcome in Major Depression NCT00461279	Centre for Addiction and Mental Health	N/A
Completed	A Study of SR58611A in the Prevention of Depression Relapse in Patients With Major Depressive Disorder NCT00345098	Sanofi	Phase 3
Completed	Evaluation of Deep Transcranial Magnetic Stimulation (TMS) H-Coil in the Treatment of Major Depression NCT00445237	Shalvata Mental Health Center	Phase 1
Completed	Thinking Skills for Work in Severe Mental Illness NCT01926613	Dartmouth-Hitchcock Medical Center	N/A
Completed	An Open Trial of Duloxetine on Comorbid Major Depression and Chronic Headache NCT00531895	Kraepelin Psiquiatria Clinica	Phase 4
Completed	Acamprosate in Alcoholics With Comorbid Anxiety or Depression NCT00330174	Medical University of South Carolina	Phase 4
Unknown	A Study of Omega-3 as an Augmentor of Antidepressant Treatment for Major Depression NCT00289484	The University of New South Wales	Phase 2
Unknown	Effect of Partial Sleep Deprivation on Cognition and Cytokines in Individuals With Major Depression NCT00291239	Zentrum für Integrative Psychiatrie	Phase 4
Unknown	Clinical Pharmacogenomics of Antidepressant Response NCT00269334	National Health Research Institutes, Taiwan	Phase 4
Completed	Mineralocorticoid Receptor in the Treatment of Severe Depression NCT00295347	Universitätsklinikum Hamburg-Eppendorf	N/A
Completed	Brain Abnormalities in Late-Onset Major Depression NCT00260468	University of Aarhus	—
Completed	Essential Fatty Acids for Major Depression NCT00256412	University of Iowa	N/A
Unknown	A Study of Omega-3 as a Treatment for Major Depression NCT00238758	The University of New South Wales	Phase 2
Completed	Decreasing Risk of Coronary Artery Disease in Schizophrenia by Omega-3 Fatty Acid Supplementation NCT00167310	University of Pittsburgh	Phase 2
Unknown	Effect of Escitalopram vs. Reboxetine on Gastro-intestinal Sensitivity of Patients With Major Depressive Disor NCT00209807	Hospital Universitari Vall d'Hebron Research Institute	Phase 4
Completed	Chronos: the Use of Chronobiological Treatment in Depression NCT00149110	Hillerod Hospital, Denmark	N/A
Completed	Low Dose St John's Wort for Depression NCT05477472	Ceres Heilmittel AG	—
Suspended	Selenium as Augmentation Treatment for Sertraline Resistant Major Depression NCT02890212	University of Sao Paulo General Hospital	N/A
Withdrawn	Expanding and Testing VA Collaborative Care Models for Depression NCT00119028	US Department of Veterans Affairs	N/A
Completed	Evaluation of Three Continuation Therapies After ECT Concerning Efficacy and Cognition in Severly Depressed Pa NCT00437385	Charite University, Berlin, Germany	Phase 1
Terminated	Use of Risperidone in ECT for Treatment Resistant Depression NCT00203723	University of California, Los Angeles	Phase 4
Completed	Magnetic Seizure Therapy (MST) for Treatment Resistant Major Depression NCT00770783	University Hospital, Bonn	Phase 3
Completed	Treatment-Resistant Depression, Hippocampus Atrophy and Serotonin Genetic Polymorphism NCT00704860	University of Ottawa	Phase 4
Completed	Are Two Antidepressants a Good Initial Treatment for Depression? NCT00296712	New York State Psychiatric Institute	Phase 4
Completed	Spirituality Teaching Program for Depressed Adults NCT00322777	Canadian Institute of Natural and Integrative Medicine	N/A
Completed	Zinc Supplementation of Imipramine Therapy NCT00693680	Polish Academy of Sciences	N/A
Completed	Treatment of Depression Following Multiple Brain Tests NCT00296777	New York State Psychiatric Institute	Phase 4
Unknown	Efficacy of 18-Months of Antidepressive Medication Plus CBT or Dynamic or Supportive Psychotherapy for Recurre NCT00220623	Sir Mortimer B. Davis - Jewish General Hospital	Phase 3
Completed	Depression Treatment in General Medical Settings NCT00797901	University of Puerto Rico	N/A
Completed	The Use of Galantamine HBr (Reminyl) in Electroconvulsive Therapy: Impact on Mood and Cognitive Functioning NCT00566735	Massachusetts General Hospital	Phase 3
Completed	Lexapro and Pramipexole and to Treat Major Depression NCT00086307	National Institute of Mental Health (NIMH)	Phase 2
Completed	Treating Depression Among Low-Income Patients With Cancer NCT00565110	University of Southern California	N/A
Terminated	Fluoxetine Versus Fluoxetine Plus DU125530 in Major Depressive Disorder NCT01119430	Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau	Phase 2
Completed	Effects of Ghrelin on the Sleep-EEG and Nocturnal Secretion of Hormones NCT00447512	Max-Planck-Institute of Psychiatry	N/A
Completed	Transcranial Magnetic Stimulation (rTMS) Accelerates the Response to Escitalopram in Major Depression NCT00149071	Hillerod Hospital, Denmark	N/A
Completed	Reliability and Validity of the MINI International Neuropsychiatric Interview for Children and Adolescents (MI NCT00579267	University of South Florida	—
Completed	Telephone Care as a Substitute for Routine Psychiatric Medication NCT00105885	US Department of Veterans Affairs	N/A
Completed	Treatment Choices for Improving Adherence and Outcome NCT00194948	Weill Medical College of Cornell University	N/A
Completed	PUFA Augmentation in Treatment of Major Depression NCT00067301	National Center for Complementary and Integrative Health (NCCIH)	Phase 3
Completed	Evaluation Study of TIDES Depression Care Quality Improvement Intervention NCT00105820	US Department of Veterans Affairs	N/A
Unknown	Risperidone Augmentation Therapy in Patients Who Have Failed or Only Partially Responded to a Trial of Antidep NCT00174577	Rhode Island Hospital	Phase 3
Completed	Provigil in Conjunction With SSRIs for the Treatment of Mild or Moderate Depression With Attendant Symptoms of NCT00208715	Emory University	Phase 4
Completed	Triiodothyronine (T3) Supplementation in the Treatment of Bipolar and Unipolar Depression. NCT00158990	Hadassah Medical Organization	Phase 3
Withdrawn	Discontinuation Study Of Citalopram (Antidepressant) in Depressed Adolescents NCT00249886	Sunnybrook Health Sciences Centre	Phase 3
Completed	Safety, Tolerability and Efficacy of the Transdermal System in Elderly Subjects With Major Depression NCT00285766	Somerset Pharmaceuticals	Phase 3
Terminated	Trial of Pindolol Augmentation in Venlafaxine Treated Patients With Major Depression NCT00159146	Hillerod Hospital, Denmark	N/A
Completed	Depression: The Search for Treatment-Relevant Phenotypes-Pilot Study NCT00222820	University of Pittsburgh	Phase 4
Completed	Treatment of Depressed Chronic Obstructive Pulmonary Disease Patients NCT00151372	Weill Medical College of Cornell University	N/A
Completed	Effect of Specific Anti-Toxoplasmatic Add-on Medication in Toxoplasma Gondii Seropositive Individuals With Sch NCT00300404	Zentrum für Integrative Psychiatrie	Phase 3
Completed	Pharmacotherapy in Depression With Panic Spectrum NCT00177996	University of Pittsburgh	Phase 4
Completed	Health Care Management and Rehabilitation Skills Training for Treating Serious Mental Illness in Older People NCT00169052	Dartmouth-Hitchcock Medical Center	N/A
Terminated	Sequential Tranylcypromine (TC), TC + Dextroamphetamine and TC + Triiodothyronine for Refractory Depression NCT00296686	New York State Psychiatric Institute	Phase 4
Completed	Testosterone and Major Depression NCT00286546	University Health Network, Toronto	—
Terminated	Interpersonal Psychotherapy for Severely Depressed Inpatients NCT00325000	German Research Foundation	N/A
Unknown	Evaluation of Programs of Coordinated Care and Disease Management NCT00627029	Mathematica Policy Research, Inc.	N/A
Unknown	The Neurobiology of Depressive Illness NCT00168493	Baker Heart Research Institute	N/A
Completed	Antidepressant Treatment of Mexican-Americans: UCLA Pharmacogenetics and Pharmacogenomics Research Group NCT00265291	National Institute of General Medical Sciences (NIGMS)	Phase 2
Unknown	Longitudinal Study of People Presenting for First Treatment of a Mood Disorder NCT01529905	McMaster University	—
Completed	Improving Depression Care for Elders: Coordinating Center NCT01561105	University of California, Los Angeles	N/A
Completed	Treatment of Major Depression With St. John's Wort (Hypericum) NCT00005013	National Institute of Mental Health (NIMH)	N/A
Completed	Improving Outcome in Schizophrenia Through Identification of Genetic Risk Factors NCT00178932	Northwestern University	N/A
Completed	Preventing Depression Recurrence in Diabetes NCT00374426	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)	Phase 4
Completed	Physiologic Monitoring of Antidepressant Response NCT00792168	University of California, Los Angeles	Phase 4
Completed	Thyroid Medication and Antidepressants for Treating Major Depression NCT00208702	Emory University	Phase 4
Completed	Neurocognitive Outcomes of Depression in the Elderly NCT00570583	Duke University	—
Completed	Prozac Treatment of Major Depression: Discontinuation Study NCT00427128	New York State Psychiatric Institute	Phase 4
Completed	Dichotic Listening as a Predictor of Medication Response in Depression NCT00296725	New York State Psychiatric Institute	Phase 1 / Phase 2
Completed	Antidepressant Prophylaxis for Interferon-Induced Depression: Efficacy of Paroxetine NCT00357045	Portland VA Medical Center	Phase 4