NCT01870219

Effects of Sevoflurane and Ketamine on QT in Electroconvulsive Therapy

The Effects of Sevoflurane or Ketamine on QTc Interval During Electroconvulsive Therapy

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: Inonu University · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study was to evaluate the effect of sevoflurane or ketamine on the QTc and Tp-e interval during in patients with major depression.

Detailed description

Patients enrolled in the study are randomly allocated by computer-generated random numbers to receive either sevoflurane or ketamine for their initial ECT session. They subsequently receive an alternative study drug in their next session, continuing to alternate between drugs at each session until the sixth session. In group S, sevoflurane are initiated at %8 sevoflurane for anesthesia induction and maintained at 2% to %4 until the electrical stimulus is delivered, In group K, ketamine are given to 1mg/kg ıv bolus. Electrical stimulus is delivered via bilateral frontotemporal electrodes.The mean arterial pressure (MAP), HR, and ECG are recorded before anesthetic induction (T1), after anesthetic induction (T2) and at 0, 1, 3, 10 min after the seizure ended (T3, T4, T5 and T6, respectively).The QT interval and Tp-e interval are measured by one author, who was unaware of group allocation.

Conditions

• Major Depression
• Electroconvulsive Therapy

Interventions

Type	Name	Description
DRUG	Sevoflurane	sevoflurane was initiated at %8 sevoflurane for anesthesia induction and maintained at 2% to %4 until the electrical stimulus was delivered
DRUG	Ketamine	ketamine was given to 1mg/kg ıv bolus

Timeline

• Start date: 2012-02-01
• Primary completion: 2013-04-01
• Completion: 2013-05-01
• First posted: 2013-06-06
• Last updated: 2013-06-06

Locations

1 site across 1 country: Turkey (Türkiye)