NCT00296712

Are Two Antidepressants a Good Initial Treatment for Depression?

Combined Escitalopram/Bupropion as First Line Treatment for Depression, a Replication.

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 55 (actual)
• Sponsor: New York State Psychiatric Institute · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Relatively drug naive patients will receive two antidepressant medications as initial treatment.

Detailed description

While antidepressant medications are often effective in relieving depressive symptoms, at least 60% of patients do not remit with the first agent tried. This pilot study will assess whether giving two standard medications simultaneously (i.e., Escitalopram and Bupropion) is both tolerated and improves response while decreasing drop outs. This is a replication of a previous study.

Conditions

• Major Depression
• Dysthymia
• Depression NOS

Interventions

Type	Name	Description
DRUG	escitalopram + bupropion	same dosing as for monotherapy arms

Timeline

• Start date: 2005-02-01
• Primary completion: 2006-07-01
• Completion: 2006-07-01
• First posted: 2006-02-27
• Last updated: 2012-04-27

Locations

1 site across 1 country: United States