Trials / Completed
CompletedNCT00300404
Effect of Specific Anti-Toxoplasmatic Add-on Medication in Toxoplasma Gondii Seropositive Individuals With Schizophrenia or Major Depression
Effect of Add-on Anti-Toxoplasmosis Treatment on Parameters Defining Toxoplasma Gondii Infection and on Psychopathology in Patients With Schizophrenia or Major Depression Serologically Positive for Toxoplasma Gondii - Phase 3 Study
- Status
- Completed
- Phase
- Phase 3
- Study type
- Interventional
- Enrollment
- 40 (planned)
- Sponsor
- Zentrum für Integrative Psychiatrie · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
We investigate whether the add-on specific antitoxoplasmatic medication has positive effects in individuals with schizophrenia or major depression seropositive for Toxoplasma gondii (TG) infection. As TG modulates neurotransmitter metabolism affecting serotonin and dopamine we hypothesize that this chronic persistent infection might play a role for depressive and psychotic symptomatology. Therefore, on the basis of an ex juvantibus approach, specific anti TG medication might further improve psychiatric symptomatology in affected patients. This is investigated in a double-blind, placebo-controlled, randomized treatment trial.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | daraprim | |
| DRUG | pyrimethamine | |
| DRUG | folinic acid |
Timeline
- Start date
- 2002-01-01
- Completion
- 2005-09-01
- First posted
- 2006-03-08
- Last updated
- 2006-05-22
Source: ClinicalTrials.gov record NCT00300404. Inclusion in this directory is not an endorsement.