NCT01368432

Lexapro for the Treatment of Traumatic Brain Injury (TBI) Depression & Other Psychiatric Conditions

Escitalopram (Lexapro) for the Treatment of TBI Depression and Other Comorbid Psychiatric Conditions

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 16 (actual)
• Sponsor: Johns Hopkins University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This research is being done to see if a drug called escitalopram (Lexapro) is helpful to people who are suffering from depression after traumatic brain injury (TBI).

Detailed description

Despite it's high prevalence, little is known about the pharmacological treatment of depression following Traumatic Brain Injury (TBI). This is because of a lack of randomized controlled studies in the treatment of post-TBI depression. This study is designed to examine the safety and effectiveness of escitalopram in the treatment of post-TBI depression. It will also investigate metabolic changes and neural pathways associated with post-TBI depression and metabolic alterations after treatment through neuroimaging.

Conditions

• TBI
• Major Depression
• Other Psychiatric Disorders

Interventions

Type	Name	Description
DRUG	Escitalopram	Escitalopram 10 mg or 20 mg daily for 12 weeks by mouth
DRUG	Placebo	Sugar pill placebo

Timeline

• Start date: 2010-04-01
• Primary completion: 2012-12-01
• Completion: 2013-03-01
• First posted: 2011-06-08
• Last updated: 2016-10-24
• Results posted: 2016-10-24

Locations

1 site across 1 country: United States