NCT01325831

Changes of Functional Connectivity After rTMS in Depression

Change of Dopamine Pathway After rTMS Treatment in Major Depressive Disorder

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 44 (actual)
• Sponsor: Yonsei University · Academic / Other
• Sex: All
• Age: 19 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

In order to explore the effect of repetitive TMS, which has shown to be effective in intractable depression, we will examine resting-state, default-mode network functional connectivity in patients with major depression. We will use a double-blind, sham-controlled design. Our target sample size is 60(30 patients will be treated by active rTMS, the other 30 will be treated by sham rTMS). We will apply 10-day course of 10 Hz rTMS on left dorsolateral prefrontal cortex of the subjects.

Detailed description

Up to now, 24 patients with major depression and 6 normal controls are enrolled. Twenty-three patients and 4 normal participants have taken 10 days rTMS. One patients and one control withdrew their consent without any reason and one control withdrew the consent because of headache. We scanned fMRIs(to examine functional connectivity)twice for each participant, which were taken 3 days before the first and 3 days after the last rTMS. All of participants have not reported side effects except mild headahe. There's been no seizure event up to now.

Conditions

• Major Depression

Interventions

Type	Name	Description
DEVICE	repetitive transcranial magnetic stimulation(rTMS)	10-day course of 10 Hz rTMS on left dorsolateral prefrontal cortex of the subjects.
DEVICE	Sham repetitive transcranial magnetic stimulation(rTMS)	Sham repetitive transcranial magnetic stimulation(rTMS)

Timeline

• Start date: 2009-05-01
• Primary completion: 2011-06-01
• Completion: 2011-06-01
• First posted: 2011-03-30
• Last updated: 2012-02-02

Locations

1 site across 1 country: South Korea