NCT05477472

Low Dose St John's Wort for Depression

Observational Study of the Efficacy and Tolerability of Low-dose Phytotherapy Using the Example of St John's Wort (Hypericum Perforatum)

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 55 (actual)
• Sponsor: Ceres Heilmittel AG · Industry
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

This observational study observes the routine use of low-dose St John's Wort herbal mother tincture in patients with major depression. It measures intensity of depression at the beginning of St Johns Wort and after 6 weeks and evaluates tolerability and compliance.

Detailed description

Herbal medicine is widely used, and high-quality evidence shows their efficacy and tolerability for specific disorders. Most of the studies, however, is conducted with standardized, relatively high dosed dry extract preparations, while other preparations such as tinctures are widely used as well. The aim of this observational study ist to document real-live use of the use of a low-dose herbal medicine preparation (a mother tincture) of St John's Wort (Hypericum perforatum), to compare depression intensity at the beginning and after 6 weeks of therapy using the Hamilton Depression Scale 17, and to evaluate tolerability and compliance. Finally, the results will be compared with results of randomized controlled trials examining high dosed dry extract preparations of St John's Wort for major depression.

Conditions

• Major Depression

Interventions

Type	Name	Description
DRUG	St John's Wort	daily intake of CERES St John's Wort mother tincture. Dose according to the treating physician.

Timeline

• Start date: 2005-08-01
• Primary completion: 2007-01-01
• Completion: 2007-01-01
• First posted: 2022-07-28
• Last updated: 2022-07-28

Locations

1 site across 1 country: Switzerland