NCT00238758

A Study of Omega-3 as a Treatment for Major Depression

A Randomised, Double-Blind, Placebo Controlled Trial of Omega-3 Polyunsaturated Fatty Acids as a Monotherapy for Major Depression

• Status: Unknown
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 128 (planned)
• Sponsor: The University of New South Wales · Academic / Other
• Sex: All
• Age: 21 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine whether omega-3 polyunsaturated fatty acids are effective as a monotherapy for depression.

Detailed description

The study will be a 6 week, parallel-group, double-blind randomized controlled trial of the efficacy of Omega-3 as a monotherapy for depression. People aged 21-65 who have major depression but are not currently on an antidepressant or planning to take an antidepressant in the next 14 weeks will be recruited. Participants will be randomly allocated to receive Omega-3 (fish oil) or placebo (paraffin oil) for 6 weeks. Participants will be followed up weekly and will be asked to rate their mood daily for the 6 week study period. Blood samples will be taken pre and post treatment to measure change in omega-3 levels. At the end of 6 weeks all participants will receive a further 8 weeks supply of omega-3.

Conditions

• Major Depression
• Dysthymia

Interventions

Type	Name	Description
DRUG	Omega-3 Polyunsaturated Fatty Acids

Timeline

• Start date: 2005-10-01
• First posted: 2005-10-13
• Last updated: 2006-09-13

Locations

1 site across 1 country: Australia