NCT02439099

Retinoic Acid Homeostasis in Neuropsychiatric Diseases

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 200 (estimated)
• Sponsor: Charite University, Berlin, Germany · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

It is hypothesized, that local retinoic acid (RA) homeostasis is functionally involved in the pathophysiology of depression. In a cross-sectional (and partly longitudinal) analysis, serum RA status will be assessed in healthy controls and subjects with Major Depression, Alzheimer's disease, alcoholism and in subjects with schizophrenia.

Detailed description

Retinoids comprise of a group of small-molecule derivatives of Vitamin A with retinoic acid (RA) representing the biologically most active endogenous form. RA has multiple functions central nervous system (CNS). It is hypothesized, that local RA homeostasis is functionally involved in the pathophysiology of numerous neuropsychiatric diseases.

Conditions

• Major Depression
• Alzheimer's Disease
• Alcoholism
• Schizophrenia

Timeline

• Start date: 2015-03-01
• Primary completion: 2022-12-01
• Completion: 2022-12-01
• First posted: 2015-05-08
• Last updated: 2021-08-09

Locations

1 site across 1 country: Germany