NCT00296725

Dichotic Listening as a Predictor of Medication Response in Depression

Dichotic Listening as a Predictor of Placebo and Medication Response in Depression

• Status: Completed
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 25 (actual)
• Sponsor: New York State Psychiatric Institute · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Depressed patients will have hearing tests and then be treated with up to three treatments (i.e., Fluoxetine, Imipramine) until remitted, to see whether test results predict specific outcomes.

Detailed description

100 depressed patients will be tested with verbal and nonverbal dichotic tests, and then treated sequentially with Fluoxetine and Imipramine until remitted. Preferential hemisphere for auditory processing will be correlated with treatment outcome.

Conditions

• Major Depression
• Dysthymia
• Depressive Disorder Not Otherwise Specified

Interventions

Type	Name	Description
DRUG	Fluoxetine	Phase 1: Fluoxetine: wk 1: 10 mg/day; wks 2-3: 20 mg/day; wks 4-5: 40 mg/day; wk 6: 60 mg/day; wks 7-12: 80 mg/day \*All increases only if tolerated.
DRUG	Imipramine	Phase 2: Imipramine wk 1: 25 mg/day; wk 2: 50 mg/day; wk 3: 100 mg/day, 150 mg/day after 3 days; wk 4: 200 mg/day, 250 mg/day after 3 days; wks 5-6: 300 mg/day. \*All increases only if tolerated.

Timeline

• Start date: 1994-04-01
• Primary completion: 2011-06-01
• Completion: 2011-06-01
• First posted: 2006-02-27
• Last updated: 2019-05-30
• Results posted: 2019-05-15

Locations

1 site across 1 country: United States