NCT00296777

Treatment of Depression Following Multiple Brain Tests

Medication Treatment Following Neuropsychologic, Dichotic and f-MRI Tests in Depressed Outpatients With Repeat f-MRI Following Treatment

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 28 (actual)
• Sponsor: New York State Psychiatric Institute · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The main purpose of this study is to correlate brain testing with treatment outcome.

Detailed description

40 medication-free Depressed Patients will receive a battery of neuropsychologic tests, standard dichotic listening tests, EEG, ERP and an f-MRI while performing a neuropsychologic test, the Simon. Once testing is completed, patients will be treated in an open treatment trial of SSRI. Non-responders will then receive Bupropion followed by Tricyclic Antidepressant if still depressed. While our main purpose is to correlate imaging testing with other measures of brain functioning, we also intend to see whether f-MRI findings demonstrate specific brain areas which differ between responders and non-responders. At the end of SSRI treatment, patients will have a second f-MRI scan to investigate any changes treatment and/or response may have caused.

Conditions

• Major Depression
• Dysthymia

Interventions

Type	Name	Description
DRUG	Escitalopram	8 weeks: up to 40 mg/day
DRUG	Bupropion	8 weeks: up to 450 mg/day (for patients without history of seizures or risk for developing seizures.
DRUG	Imipramine	8 weeks: up to 300mg/day \*if patient does not have contraindication.

Timeline

• Start date: 2004-12-01
• Primary completion: 2007-05-01
• Completion: 2007-12-01
• First posted: 2006-02-27
• Last updated: 2012-04-27

Locations

1 site across 1 country: United States