NCT00707863

Study of Brain Response to Emotional Pictures Using a Magnetic Resonance Imaging (fMRI) While on Escitalopram

fMRI and Genotype Markers of Antidepressant Side Effects and Response in Young Adults Compare to Older Adults

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 17 (actual)
• Sponsor: Indiana University School of Medicine · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to find out what parts of the brain have increased or decreased activity when people are depressed and how antidepressant medicine changes this activity in depressed patients. The genetic samples collected are to look at variation in a gene (serotonin transporter gene), which affects the functioning of the chemical serotonin in the brain

Detailed description

This study will measure the activity in different parts of the brain, while the patients are seeing some pictures, using Magnetic Resonance Imaging (MRI) scan. For this study three MRI scans will be conducted. One before the patient begins on any medication, one during the study after 3 weeks of treatment and one after six more weeks of treatment with a standard antidepressant called Escitalopram(trade name: Lexapro).

Conditions

• Major Depression

Interventions

Type	Name	Description
DRUG	Escitalopram	10 mg of Escitalopram by mouth once a day for 8 weeks

Timeline

• Start date: 2008-05-01
• Primary completion: 2012-12-01
• Completion: 2012-12-01
• First posted: 2008-07-01
• Last updated: 2016-10-17
• Results posted: 2016-10-17

Locations

1 site across 1 country: United States