NCT00289484

A Study of Omega-3 as an Augmentor of Antidepressant Treatment for Major Depression

A Randomised, Double-Blind, Placebo Controlled Trial of Omega-3 Polyunsaturated Fatty Acid as an Augmentor of Antidepressant Medication for Major Depression.

• Status: Unknown
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 52 (planned)
• Sponsor: The University of New South Wales · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine whether augmentation of antidepressant medication with Omega-3 polyunsaturated fatty acids increases the speed and degree of improvement for patients with major depression

Detailed description

The study will be a 4 week, parallel-group double blind randomised control trial of the efficacy pf Omega-3 as an augmentor of antidepressant treatment for depression. People aged between 18 and 65 with a first or new episode of depression warranting treatment with antidepressant medication will be recruited. In addition to their antidepressant medication, participants will be randomly allocated to receive either Omega-3 (fish oil) or placebo (paraffin oil)for 4 weeks. Participants will commence treatment with the antidepressant and Omega-3/placebo simultaneously. Participants will be followed up at 1,3 and 4 weeks and will be asked to rate their mood daily for the 4 week study period. Blood samples will be taken pre and post treatment to measure change in Omega-3 levels.

Conditions

• Major Depression

Interventions

Type	Name	Description
DRUG	Omega-3 Polyunsaturated Fatty Acids

Timeline

• Start date: 2006-02-01
• First posted: 2006-02-09
• Last updated: 2006-09-13

Locations

1 site across 1 country: Australia