| Not Yet Recruiting | TAVI Without On-Site Cardiac Surgery in Poland: A Randomized Multicenter Trial Protocol NCT07515768 | Medical University of Warsaw | N/A |
| Not Yet Recruiting | A Prospective, Multicenter, Observational Study Evaluating Safety and Effectiveness of SAPIEN 3 Transcatheter NCT07450196 | Chinese Academy of Medical Sciences, Fuwai Hospital | — |
| Recruiting | DELINEATE-Prospective NCT07197736 | Columbia University | — |
| Not Yet Recruiting | Deep Learning-enhanced Personalized Monitoring of Aortic Stenosis - The DETECT-AS Prognostic Study NCT06749132 | Yale University | — |
| Not Yet Recruiting | Dilation Optimisation for Uniform Bioprosthetic Leaflet Expansion NCT07430267 | The Alfred | N/A |
| Recruiting | STAR Trial (Siegel Transcatheter Aortic Valve Replacement in Patients With Symptomatic Severe Aortic Stenosis) NCT07278310 | MiRus | N/A |
| Not Yet Recruiting | Semaglutide in Patients Undergoing Transcatether Aortic Valve Replacement NCT07090343 | Leiden University Medical Center | Phase 3 |
| Not Yet Recruiting | PRessure-based Evaluation of Disease Improvement in the Course of TAVI NCT07509554 | Istanbul Mehmet Akif Ersoy Educational and Training Hospital | — |
| Not Yet Recruiting | Prospective, Long-term Evaluation of the SAPIEN 3 Ultra RESILIA Valve NCT06953206 | Institut für Pharmakologie und Präventive Medizin | — |
| Not Yet Recruiting | Multicenter Study for the Validation of Willem AI: Aortic StenoSis Early Diagnosis With AI-electrocardiogram S NCT07479992 | Idoven 1903 S.L. | — |
| Not Yet Recruiting | Application of TAVI at Experienced Interventional Cardiac Centers Without On-site Cardiac Surgery (ATLAS Study NCT06818006 | University of Alberta | Phase 4 |
| Not Yet Recruiting | Echo-Guided vs Fluoroscopy-Guided Transcatheter Aortic Valve Replacement in Patients With Aortic Stenosis（ECHO NCT07317804 | China National Center for Cardiovascular Diseases | Phase 4 |
| Not Yet Recruiting | CAPTURE-2: Controlled Arterial Protection to Ultimately Remove Embolic Material NCT07276711 | EmStop Inc | N/A |
| Not Yet Recruiting | Cardiac Amyloidosis in Patients With Aortic Stenosis NCT07170306 | Shanghai Zhongshan Hospital | — |
| Recruiting | Correlation Between an Impedance Cardiography Test for Decompensation and the Development of Left Ventricular NCT07230964 | Dermed Diagnostics, Inc. | N/A |
| Not Yet Recruiting | Optimization of Commissural Alignment During Transcatheter Aortic Valve Implantation With Evolut FX+ NCT07217691 | Oslo University Hospital | N/A |
| Recruiting | Study of the Progression of Chronic Cardiovascular Conditions NCT07420907 | Prolaio | — |
| Recruiting | Improved Outcomes With Pre-Procedure Shockwave IVL of Common Femoral Artery Access Site Prior to Large Bore Ac NCT07205068 | University of Tennessee Graduate School of Medicine | N/A |
| Not Yet Recruiting | Perioperative Intensive Statin Therapy for Neuroprotection in TAVR（PISTNT） NCT07087379 | Pan Xiangbin | Phase 4 |
| Enrolling By Invitation | Deep Learning Enhanced Detection of Aortic Stenosis - The DETECT-AS-Diagnostic Study NCT06749145 | Yale University | N/A |
| Enrolling By Invitation | TAVR vs. SAVR Study of VitaFlow Liberty® for Severe BAV Stenosis NCT06597188 | Shanghai MicroPort CardioFlow Medtech Co., Ltd. | N/A |
| Recruiting | Impact of Transcatheter Aortic Valve Implantation (TAVI) on the Gut Microbiota in Patients With Aortic Valve S NCT07052071 | Hippocration General Hospital | — |
| Recruiting | AI Assessment of Low-Gradient Aortic Stenosis Severity Based on Echocardiography NCT07144189 | National Institute of Cardiology, Warsaw, Poland | — |
| Recruiting | Early Feasibility Study of Surgical Implantation of a Polymer Prosthetic Mitral and Aortic Valve NCT07097740 | Mitrassist Lifesciences Limited Co., Ltd. | N/A |
| Recruiting | Isolated Surgical Aortic Valve Replacement in Low Risk AS Patients NCT06924151 | Osaka University | N/A |
| Enrolling By Invitation | Anatomical Determinants and Outcomes of Small Annulus Patients Undergoing TAVR in Different ASIAN Ethnicity NCT07240025 | Prince of Wales Hospital, Shatin, Hong Kong | — |
| Not Yet Recruiting | A Multicenter, Prospective, Randomized Controlled Trial to Evaluate the Efficacy of PCSK-9 Inhibitors in Delay NCT06996223 | Nanfang Hospital, Southern Medical University | EARLY_Phase 1 |
| Recruiting | Preventing Hypoxia in Sedated TAVI: SuperNO₂VA vs. Conventional Oxygen NCT07006064 | Ankara Bilkent Sehir Hastanesi | N/A |
| Recruiting | A Study of Transcatheter Aortic Valve Replacement Case Selection and Valve Sizing Using the ABC Bicuspid Sizin NCT06991517 | World Health Research Inc. | — |
| Not Yet Recruiting | 10-year Follow-up After Aortic Valve Replacement Surgery NCT06255691 | Oslo University Hospital | — |
| Recruiting | Short-term Exposure to High Altitude in Patients With Asymptomatic Aortic Stenosis NCT06894550 | Insel Gruppe AG, University Hospital Bern | N/A |
| Terminated | Feasibility Study of the transShield Embolic Protection System NCT06652841 | TransAortic Medical, Inc. | N/A |
| Not Yet Recruiting | General Anesthesia Versus Loco-Regional Anesthesia for Transcarotid Trancatheter Aortic Valve Replacement NCT06870734 | University Hospital, Caen | — |
| Enrolling By Invitation | Conscious Sedation With Suprainguinal Facia Iliaca Block Versus Ilioinguinal Iliohypogastric Block for TAVI NCT06911463 | Ain Shams University | N/A |
| Recruiting | REdo tranScatheter Aortic Valve Replacement for Transcatheter aOrtic Valve failuRE NCT06777368 | Medtronic Cardiovascular | — |
| Not Yet Recruiting | Optimization of Heart Failure (HF) Medical Therapy After Transcatheter Valve Intervention (TVI) in Patients Wi NCT06667128 | IRCCS Ospedale San Raffaele | N/A |
| Enrolling By Invitation | Demographic and Interpopulation Variations in Evaluation and Results of TAVI NCT07258706 | Poznan University of Medical Sciences | — |
| Not Yet Recruiting | Telematic Intervention for Reversing Frailty Among Older Patients with Aortic Stenosis Undergoing Transcathete NCT06742970 | Spanish Society of Cardiology | N/A |
| Recruiting | Identifying Biological Markers of Cardiovascular Events in Patients With Aortic Stenosis or TAVI NCT06713889 | Hospices Civils de Lyon | — |
| Recruiting | Biomarkers of Inflammation and Fibrosis in Conduction Disorders After TAVI NCT07201363 | Clinical Hospital Center Rijeka | — |
| Recruiting | Novel Characterization of Sex Specific Biologic Signatures in Valvular Heart Disease NCT06780241 | The Cleveland Clinic | — |
| Not Yet Recruiting | Transcatheter AortiC Valve Implantation in AorTic StenosIs CardiogenIc Shock NCT06638268 | Rigshospitalet, Denmark | N/A |
| Recruiting | AI in Outpatient Practice for Diagnosing Aortic Stenosis and Diastolic Dysfunction NCT06580158 | Mayo Clinic | — |
| Recruiting | Efficacy of Self-expandable and Balloon-expandable Valves in Patients With Ascending Aortic Dilation NCT06743568 | China National Center for Cardiovascular Diseases | N/A |
| Recruiting | Impact of Aortic Annulus Calcification on Long-Term Outcomes Following Transcatheter Aortic Valve Replacement: NCT06722066 | Eunpyeong St. Mary's Hospital | — |
| Recruiting | Transaxillary TAVR With Solely Echocardiography Guidance NCT07035847 | Chinese Academy of Medical Sciences, Fuwai Hospital | N/A |
| Not Yet Recruiting | CAN3T - Canadian TAVI Triage Tool NCT06551610 | Sunnybrook Health Sciences Centre | N/A |
| Recruiting | Loss of Y Chromosome in Aortic Stenosis NCT06595407 | University of Virginia | — |
| Recruiting | Comparison of Evolut FX Versus Sapien 3 Ultra Resilia. NCT06470022 | Christian Juhl Terkelsen | N/A |
| Active Not Recruiting | Gender-specific Evaluation of Symptom Awareness in Female Versus Male Patients with Severe Aortic Stenosis NCT06677528 | Heart and Diabetes Center North-Rhine Westfalia | — |
| Recruiting | Impact of Beta-blocker on Outcome Among Patients Undergoing Transcatheter Aortic Valve Replacement (B-TAVR) NCT06472934 | University Hospital, Basel, Switzerland | N/A |
| Completed | The ShortCut™ Continued Access Study Protocol NCT06211296 | Pi-cardia | N/A |
| Recruiting | Reversibility of Cardiac Conduction Disturbances Following TAVI NCT06481137 | Institut d'Investigació Biomèdica de Bellvitge | N/A |
| Completed | RESTORE-TAVI Pilot NCT06121921 | Barts & The London NHS Trust | N/A |
| Withdrawn | U.S. Multicenter Feasibility Trial of the F2 Filter and Delivery System for Embolic Protection During TAVR NCT06069661 | EnCompass Technologies, Inc. | N/A |
| Enrolling By Invitation | Invasive Versus Echocardiography-derived Transvalvular Gradients After TAVI Usign Balloon-expandable Transcath NCT06753227 | Deutsches Herzzentrum Muenchen | — |
| Active Not Recruiting | Ventricular Pacing Rate in Follow-up of Patients Treated With Definitive PM Implantation Post TAVI NCT06499428 | I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio | — |
| Recruiting | Dobutamine Stress Echocardiography in LF/LG Aortic Stenosis and Wild-type Transthyretin Amyloid Cardiomyopathy NCT06372301 | Steen Hvitfeldt Poulsen | N/A |
| Enrolling By Invitation | Videodensitometric Angiographic Assessment of AR in the Cath-lab for Intraprocedural Guidance of TAVI in CHINA NCT06891079 | Xijing Hospital | N/A |
| Enrolling By Invitation | Promoting Shared Decision Making for Severe Aortic Stenosis NCT06171737 | Massachusetts General Hospital | N/A |
| Recruiting | Effect of PCSK9 Inhibitors on Calcific Aortic Valve Stenosis NCT04968509 | Beijing Anzhen Hospital | Phase 3 |
| Recruiting | A Multicenter Trial Assessing the Impact of Lipoprotein(a) Lowering With Pelacarsen (TQJ230) on the Progressio NCT05646381 | Novartis Pharmaceuticals | Phase 2 |
| Unknown | PRogression Of bicuSPid-rElated aoRtOpathy in Patients Undergoing Transcatheter Aortic Valve Implantation (PRO NCT06248294 | University of Catania | — |
| Completed | Construction and Application Plan of Home Cardiac Rehabilitation for Patients Undergoing TAVR NCT06418555 | Second Affiliated Hospital, School of Medicine, Zhejiang University | N/A |
| Not Yet Recruiting | Involvement of the Gut Microbiota in Calcified Aortic Stenosis NCT06021535 | Insel Gruppe AG, University Hospital Bern | — |
| Not Yet Recruiting | Prophylactic Permanent Pacemaker in Patients With Right Bundle Branch Block Undergoing Transcatheter Aortic Va NCT05889208 | Aalborg University Hospital | N/A |
| Completed | High Flow Nasal Oxygen Cannula in Transcatheter Aortic Valve Replacement: Complications and Biomarkers NCT05958537 | Hospital Clinic of Barcelona | N/A |
| Recruiting | Post-Market Clinical Follow Up Study With Navitor Valve NCT06008080 | Abbott Medical Devices | — |
| Recruiting | Long Term Evaluation of Cardiac Arrhythmias After Transcatheter Aortic Valve Implantation -The LOCATE Registry NCT06055751 | Kansas City Heart Rhythm Research Foundation | — |
| Enrolling By Invitation | Feasibility, Safety, and Effectiveness of the ACURATE neo2 Transcatheter Heart Valve for Severe Bicuspid Aorti NCT06212050 | National University of Ireland, Galway, Ireland | — |
| Completed | Multicenter Feasibility Trial of the F2 Filter and Delivery System for Embolic Protection During TAVR NCT05893082 | EnCompass Technologies, Inc. | N/A |
| Recruiting | Comparison of Self- and Balloon-expandable Valves in Patients With Ascending Aortic Dilation Undergoing Transc NCT06009588 | China National Center for Cardiovascular Diseases | N/A |
| Unknown | Glucocorticoid Treatment in Transaortic Valve Replacement to Reduce the Incidence of Conduction Disturbances ( NCT06076824 | Hospital General Universitario de Alicante | Phase 4 |
| Active Not Recruiting | Use of DurAVR™ THV System in Subjects With Severe Aortic Stenosis: Early Feasibility Study NCT05712161 | Anteris Technologies Ltd. | N/A |
| Completed | Prevalence of Transthyretin Cardiac Amyloidosis in Clinically Significant Aortic Stenosis NCT04899180 | Mayo Clinic | EARLY_Phase 1 |
| Not Yet Recruiting | Biomarkers and Mechanisms of Disease Progression and Outcome of Aortic Stenosis in Humans NCT05851209 | Heinrich-Heine University, Duesseldorf | — |
| Recruiting | The Scottish Aortic Stenosis LongiTudinal Imaging and biomarkeR (SALTIRE) Programme NCT06047561 | University of Edinburgh | — |
| Recruiting | Transfemoral Transcatheter Aortic Valve Implementation at Hospital Without On-site Cardiac Surgery: Early Clin NCT05886517 | AUSL Romagna Rimini | N/A |
| Recruiting | Feasibility Trial of the F2 Filter and Delivery System for Embolic Protection During TAVR NCT05866640 | EnCompass Technologies, Inc. | EARLY_Phase 1 |
| Recruiting | Non-antithrombotic Therapy After Transcatheter Aortic Valve Implantation Trial NCT06007222 | OCEAN-SHD Study Group | Phase 4 |
| Unknown | Aortic Stenosis and Cardiac Amyloidosis NCT06129331 | Medical University of Vienna | — |
| Not Yet Recruiting | A Clinical Trial of the Transcatheter Aortic Valve Implantation System With a Prospective, Multi-Center, One-A NCT05673525 | Chinese Academy of Medical Sciences, Fuwai Hospital | N/A |
| Completed | The Effect of Education and Follow-up Program in Patients Undergoing TAVI NCT05625269 | Dokuz Eylul University | N/A |
| Unknown | Real-time Pressure Volume Loop Monitoring as a Guide for Enhanced Understanding of Changes in Elemental Cardio NCT06204783 | Erasmus Medical Center | — |
| Recruiting | Fibrosis in Chronic and Delayed Myocardial Infarction NCT05756608 | University of Edinburgh | — |
| Active Not Recruiting | PROVE ACURATE neo2™ - Post Market Safety and Performance Surveillance in Aortic Stenosis NCT05539573 | University of Leipzig | — |
| Terminated | OpSens PRIME CLASS NCT05070130 | Opsens, Inc. | — |
| Unknown | Feasibility of 3D Printed Models of Aortic Stenosis in Guiding TAVI Procedure NCT05484713 | Cardio Med Medical Center | — |
| Recruiting | Effect of Colchicine on the Progression of Aortic Valve Stenosis - a Pilot Study NCT05253794 | Ottawa Heart Institute Research Corporation | Phase 2 / Phase 3 |
| Completed | Portico and Navitor India Clinical Trial NCT05171712 | Abbott Medical Devices | N/A |
| Recruiting | Changes of Ascending Aortic Diameter in Patients Undergoing Transcatheter Aortic Valve Replacement NCT05739253 | China National Center for Cardiovascular Diseases | — |
| Completed | ACURATE Prime XL Human Feasibility Study NCT05224245 | Boston Scientific Corporation | N/A |
| Unknown | Effect of Dapagliflozin on Myocardial and Renal Function Following Aortic Valve Stenosis Intervention NCT05241431 | University of Aarhus | Phase 2 / Phase 3 |
| Unknown | Electronic Physician Notification to Facilitate the Recognition and Management of Severe Aortic Stenosis: The NCT05230225 | Massachusetts General Hospital | N/A |
| Completed | Prospective Evaluation of Neurocognition in Patients Undergoing Transcatheter Aortic Valve Replacement NCT05614986 | Baylor Research Institute | — |
| Unknown | Role of Aortic Valve Composition in Pathophysiology and Diagnosis of Aortic Stenosis NCT06136689 | Medical University of Warsaw | — |
| Unknown | Iron Supplementation in TAVI and SAVR Patients With Iron Deficiency NCT04786769 | Hospital de Santa Cruz, Portugal | Phase 4 |
| Recruiting | An Integrated Prenatal and Postnatal Treatment Model for the Treatment of Newborns With Critical Congenital He NCT06768008 | Beijing Anzhen Hospital | — |
| Recruiting | AntiCoagulation Versus AcetylSalicylic Acid After Transcatheter Aortic Valve Implantation NCT05035277 | Oslo University Hospital | Phase 3 |
| Completed | Portico Valve-in-Valve Retrospective Registry NCT05002088 | Abbott Medical Devices | — |
| Completed | On Dose Efficiency of Modern CT-scanners in Chest Scans NCT04996693 | University Hospital Augsburg | N/A |
| Completed | Standardized Invasive Hemodynamics for Elevated Gradients Post TAVR (DISCORDANCE TAVR) NCT04827238 | University of British Columbia | — |
| Completed | Transcatheter Aortic Valve Replacement (TAVR) Effects on Cardiac Conduction System NCT04982406 | Beth Israel Deaconess Medical Center | — |
| Completed | SAPIEN 3 Ultra EU PMS NCT04860752 | Edwards Lifesciences | — |
| Recruiting | HANGZHOU Solution in Bicuspid AS Undergoing TAVR NCT04722796 | Second Affiliated Hospital, School of Medicine, Zhejiang University | N/A |
| Unknown | Mechanisms of Excess Risk in Aortic Stenosis NCT04627987 | University College, London | — |
| Completed | Dapagliflozin After Transcatheter Aortic Valve Implantation NCT04696185 | Spanish Society of Cardiology | Phase 4 |
| Recruiting | Evaluating Infrasonic Hemodynography NCT04636892 | Scripps Health | N/A |
| Unknown | Cerebral Lesion and Neurocognitive Status Changes After TAVR NCT04678934 | Second Xiangya Hospital of Central South University | — |
| Recruiting | Staged Complete Revascularization for Coronary Artery Disease vs Medical Management Alone in Patients With AS NCT04634240 | University of British Columbia | N/A |
| Completed | transShield Embolic Protection System Feasibility Study NCT04585308 | TransAortic Medical, Inc. | N/A |
| Completed | Cardiac Amyloidosis Prevalence and Outcome in Aortic Stenosis Patients Undergoing Transcatheter Aortic Valve I NCT05384418 | CHU de Reims | N/A |
| Completed | Atrial Amyloid May Influence Outcomes in Patients Undergoing Surgical Aortic Valve Replacement NCT07105501 | Germans Trias i Pujol Hospital | — |
| Withdrawn | GPx Activity in Subjects With Aortic Stenosis Undergoing TAVR NCT04268160 | University of Florida | — |
| Unknown | Coronary Artery Disease in Elderly People Referred for TAVI NCT04930510 | University Hospital, Montpellier | — |
| Recruiting | Phenotyping Heterogeneity and Regionality of the Aorta NCT05603520 | Heinrich-Heine University, Duesseldorf | — |
| Unknown | IV Sodium Ferric Gluconate Complex in Patients Undergoing TAVI NCT04797832 | Rambam Health Care Campus | Phase 4 |
| Active Not Recruiting | Optimal Timing of Transcatheter Aortic Valve Implantation and Percutaneous Coronary Intervention - The TAVI PC NCT04310046 | University of Zurich | N/A |
| Completed | Conduction Disease After Transcatheter Aortic Valve Replacement NCT04489095 | Henry Ford Health System | N/A |
| Recruiting | SMART Watch Facilitated Early Discharge in Patients Undergoing Transcatheter Aortic Valve Replacement NCT04454177 | Second Affiliated Hospital, School of Medicine, Zhejiang University | — |
| Recruiting | The HALT Biomarker Study NCT04552275 | Massachusetts General Hospital | Phase 1 |
| Unknown | TAVR Without Predilatation NCT04350658 | University Hospital, Montpellier | — |
| Completed | COronary and MICrocirculatory Measurements in Patients With Aortic Valve Stenosis. NCT04420325 | Universitaire Ziekenhuizen KU Leuven | — |
| Unknown | Impact of Home-based Cardiac Rehabilitation on Outcomes After TAVR NCT04166682 | Second Affiliated Hospital, School of Medicine, Zhejiang University | N/A |
| Unknown | First in Human Feasibility Study With ADAPT 3D - ALR for Aortic Leaflet Repair NCT04178213 | Anteris Technologies Ltd. | N/A |
| Recruiting | The Early Valve Replacement in Severe ASYmptomatic Aortic Stenosis Study NCT04204915 | University of Leicester | N/A |
| Recruiting | Angiotensin Receptor Blockers in Aortic Stenosis NCT04913870 | Institut universitaire de cardiologie et de pneumologie de Québec, University Laval | Phase 4 |
| Not Yet Recruiting | Avr Thrombosis OutcoMe Study NCT04234841 | East and North Hertfordshire NHS Trust | — |
| Suspended | Aortic Stenosis Evaluated Via Modern Ballistocardiography and Seismocardiography NCT04231201 | Erasme University Hospital | — |
| Active Not Recruiting | CMR-AI and Outcomes in AS NCT06128876 | Medical University of Vienna | — |
| Completed | Safety and Efficacy of TaurusOne® Transcatheter Aortic Valve Replacement System With Retrievable Delivery Cath NCT04744857 | Peijia Medical Technology (Suzhou) Co., Ltd. | N/A |
| Unknown | Treatment of Concomitant Mitral Regurgitation by Mitral Valve Clipping in Patients With Successful Transcathet NCT04009434 | Technische Universität Dresden | N/A |
| Completed | Impact of Pre-procedure Cognitive Status on Outcome at 3 Months After Transcatheter Aortic Valve Implantation NCT04564534 | Centre Hospitalier Universitaire de Besancon | — |
| Completed | Aortic Cross-clamp and Opening After Transcatheter Aortic Valve Implantation: a Real Issue? NCT05721820 | Michele De Bonis | — |
| Completed | Impact of Predilatation Between Self-expanding Valves NCT04157920 | National and Kapodistrian University of Athens | N/A |
| Unknown | Transcatheter Treatment for Combined Aortic and Mitral Valve Disease. The Aortic+Mitral TRAnsCatheter (AMTRAC) NCT04031274 | Rabin Medical Center | — |
| Recruiting | Comparative Imaging Assessment of Valvular Heart Disease NCT04126018 | The Cleveland Clinic | — |
| Completed | Role of Elastin Metabolites in Aortic Remodelling in AS NCT03883490 | University of Leicester | — |
| Withdrawn | Vivio AS (Aortic Stenosis) Algorithm Optimization Study NCT04068402 | Avicena LLC | N/A |
| Active Not Recruiting | ACURATE IDE: Safety and Effectiveness Study of ACURATE Valve for Transcatheter Aortic Valve Replacement NCT03735667 | Boston Scientific Corporation | N/A |
| Unknown | Comparison of Sutureless Vs. Standard Biological Prostheses for Surgical Aortic Valve Replacement NCT03965065 | Hospital San Carlos, Madrid | N/A |
| Withdrawn | Depression and Major Adverse Events in Older Patients Who Undergo a Transcatheter Aortic Valve Implantation NCT03995914 | University Hospital, Montpellier | — |
| Terminated | Radial Versus Femoral Secondary Access During TAVI NCT03879824 | Carilion Clinic | N/A |
| Completed | PRospective Evaluation Complementing Investigation With Acurate Neo Device NCT03846557 | Fundación EPIC | — |
| Recruiting | Prediction of Long-term Outcome in Aortic Stenosis After Valve Intervention NCT05629104 | Uppsala University | — |
| Completed | Vivio AS (Aortic Stenosis) Detection Study NCT04066634 | Avicena LLC | N/A |
| Unknown | Fluid REsponsiveness and Arterial ELASTANCE in Patients With Septic Shock or After Aortic Surgery NCT04388267 | Central Hospital, Nancy, France | — |
| Unknown | TMAO in Patients With Severe Aortic Stenosis NCT04406805 | Medical University of Warsaw | — |
| Unknown | Treatment of Aortic Stenosis in Brazil: Cost-Utility Analysis of TAVI vs SAVR NCT04067089 | Hospital do Coracao | N/A |
| Completed | Reobtain Coronary Ostia Cannulation Beyond Transcatheter Aortic Valve Stent (RE-ACCESS) NCT04026204 | University of Catania | — |
| Completed | Study to Evaluate the Effect on Improvement of LVH by the Control of BP in Hypertension Patients With AV Disea NCT03666351 | Hanmi Pharmaceutical Company Limited | Phase 4 |
| Completed | Mechanism of Decompensation Evaluation - Aortic Stenosis NCT03332745 | University of Edinburgh | — |
| Unknown | Transcatheter Aortic Valve Replacement With Extracorporeal Life System Support NCT04160624 | Xijing Hospital | N/A |
| Unknown | Strategies to Prevent Transcatheter Heart Valve Dysfunction in Low Risk Transcatheter Aortic Valve Replacement NCT03557242 | Medstar Health Research Institute | N/A |
| Unknown | Biological Factors Associated With Subclinical Valvular Thrombosis NCT03847948 | Hospital San Carlos, Madrid | — |
| Completed | The TransCatheter Valve and Vessels Trial NCT03424941 | Maatschap Cardiologie Zwolle | N/A |
| Completed | China S3: Safety and Effectiveness of Edwards Lifesciences SAPIEN 3 THV in the Chinese Population NCT03466918 | Edwards Lifesciences | N/A |
| Terminated | A Prospective Study of Fractional Flow Reserve Assessment of Intermediate Coronary Stenoses in Severe Aortic S NCT03442400 | The Cleveland Clinic | N/A |
| Terminated | Transmural Systems Transcaval Closure Device for Transcaval Access Ports During Transcatheter Aortic Valve Rep NCT03432494 | National Heart, Lung, and Blood Institute (NHLBI) | N/A |
| Terminated | CHANGE Neo™ TA Registry With ACURATE Neo™ Aortic Bioprosthesis and ACURATE Neo™ TA Transapical Delivery System NCT03454360 | Symetis SA | — |
| Recruiting | VitaFlow™ II Transcatheter Aortic Valve System Pre-market Trial NCT04414878 | Shanghai MicroPort CardioFlow Medtech Co., Ltd. | N/A |
| Unknown | CoreValve Evolut Pro Prospective Registry NCT03423459 | Medstar Health Research Institute | — |
| Completed | Positron Emission Tomography / Magnetic Resonance Imaging in Aortic Stenosis NCT03352089 | University of Edinburgh | — |
| Completed | Cardiac Magnetic Resonance Imaging Versus Computed Tomography to Guide Transcatheter Aortic Valve Replacement NCT03831087 | Medical University Innsbruck | N/A |
| Unknown | Safety and Efficacy of TaurusOne® Transcatheter Aortic Valve System in Patients With Severe Calcific Aortic St NCT04815785 | Peijia Medical Technology (Suzhou) Co., Ltd. | N/A |
| Completed | China XT: Safety and Effectiveness of Edwards Lifesciences SAPIEN XT THV in the Chinese Population NCT03314857 | Edwards Lifesciences | N/A |
| Completed | Early Detection of Aortic Stenosis in the Community During Flu Vaccination NCT03250806 | Institut für Pharmakologie und Präventive Medizin | — |
| Completed | Implantable Sensor in Aortic Stenosis NCT06826183 | Barts & The London NHS Trust | — |
| Completed | The PROTEMBO SF Trial NCT03325283 | Protembis GmbH | N/A |
| Active Not Recruiting | Transcatheter Aortic Valve Replacement Versu Surgical Aortix Valve Replacement for Treating Elderly Patients W NCT03383445 | Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec | N/A |
| Completed | 18-F Sodium Fluoride (18F-NaF) PET for the Assessment of Bioprosthetic Aortic Valve Durability and Outcomes NCT03095313 | Cedars-Sinai Medical Center | Phase 2 |
| Unknown | Aortic Stenosis in Subjects With Heterozygous Familial Hypercholesterolemia on Prolonged Treatment With Statin NCT03310671 | Instituto Aragones de Ciencias de la Salud | — |
| Withdrawn | Interest of Pulse Wave Velocity Measurement as a Predictor of Severity of Aortic Stenosis NCT03140735 | Centre Hospitalier Universitaire, Amiens | N/A |
| Unknown | Left Ventricular Reverse Remodeling In Aortic Valve Replacement With Single Strip Pericardium Versus Mechanica NCT04056832 | Fakultas Kedokteran Universitas Indonesia | N/A |
| Withdrawn | Conscious Sedation vs General Anesthesia in TAVR Patients NCT03084978 | Montefiore Medical Center | N/A |
| Recruiting | PARTNER 3 Trial - Aortic Valve-in-Valve NCT03003299 | Edwards Lifesciences | N/A |
| Completed | PRospective Observation of Aortic reGuRgitation aftEr TAVI and progreSS Over Time: PROGRESS PVL Registry NCT02987894 | Symetis SA | — |
| Unknown | Rivaroxaban or Aspirin for Biological Aortic Prosthesis NCT02974920 | Christian Torp-Pedersen | Phase 4 |
| Completed | Study on Heart Block Risks Using Outcome-Based Modeling NCT07065123 | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | — |
| Completed | ACURATE Neo™ AS Aortic Bioprosthesis for Implantation Using the ACURATE neoTM AS TF Transfemoral Delivery Syst NCT02909556 | Symetis SA | N/A |
| Completed | Reactive Oxygen Species Following Aortic Valve Replacement NCT02841917 | University Hospital Southampton NHS Foundation Trust | — |
| Active Not Recruiting | A Clinical Trial of Transcatheter Aortic Valves in Dialysis Patients (Japan) NCT02903420 | Edwards Lifesciences | N/A |
| Recruiting | The Role of Cardiac Mechanics, Biomarkers and Frailty in Aortic Stenosis NCT02856620 | Christine Henri | — |
| Unknown | Temporary Pacemaker in Transcatheter Aortic Valve Implantation Patients NCT02768064 | Hadassah Medical Organization | N/A |
| Recruiting | Heart Failure and Aortic Stenosis Transcriptome NCT03268135 | IRCCS Policlinico S. Donato | — |
| Completed | Self-Centering Guide Catheter Feasibility Study NCT02639494 | Boston Scientific Corporation | N/A |
| Completed | Comparison of Left Atrial Appendage Occlusion vs Standard Medical Therapy in Patients in AF Undergoing TAVI NCT03088098 | University of Zurich | N/A |
| Completed | Association of Type of Anesthetic and Outcomes in Transfemoral Aortic Valve Replacement NCT02786264 | Yale University | — |
| Completed | Does Cardiac REhabilitation Improve Functional, Independence, Frailty and Emotional outCOmes Following Trans C NCT02921880 | Royal Brompton & Harefield NHS Foundation Trust | N/A |
| Completed | Transfemoral Transcatheter Aortic Valve Implantation With or Without Predilation of the Aortic Valve (EASE-IT NCT02760771 | Institut für Pharmakologie und Präventive Medizin | — |
| Unknown | 18F-NaF Uptake and Aortic Stenosis Progression NCT02740088 | Seoul St. Mary's Hospital | — |
| Unknown | SecOnd-generation seLf-expandable Versus Balloon-expandable Valves and gEneral Versus Local Anesthesia in TAVI NCT02737150 | Helios Health Institute GmbH | N/A |
| Terminated | Perceval Sutureless Implant Versus Standard-Aortic Valve Replacement NCT02673697 | Corcym S.r.l | N/A |
| Completed | PERIGON Japan Trial NCT02686814 | Medtronic Cardiac Surgery | N/A |
| Active Not Recruiting | PARTNER 3 Trial: Safety and Effectiveness of the SAPIEN 3 Transcatheter Heart Valve in Low Risk Patients With NCT02675114 | Edwards Lifesciences | N/A |
| Completed | EDWARDS INTUITY Elite Valve System NCT02907463 | Edwards Lifesciences | — |
| Unknown | Direct Aortic vs Subclavian Access for TAVI: a Review of the Outcomes in the UK NCT02695147 | Royal Sussex County Hospital | — |
| Unknown | Dedicated Sheath Feasibility Study NCT02617524 | Valve Medical | N/A |
| Completed | Feasibility of Transcatheter Aortic Valve Replacement in Low-Risk Patients With Symptomatic, Severe Aortic Ste NCT02628899 | Medstar Health Research Institute | N/A |
| Completed | Automated Phonocardiography Analysis in Adults NCT03600051 | CSD Labs GmbH | — |
| Completed | ACURATE Neo™ TA Delivery System in Patient With Severe Aortic Stenosis NCT02950428 | Symetis SA | N/A |
| Completed | Prehabilitation to Improve Functional and Clinical Outcomes in Patients With Aortic Stenosis NCT02597985 | Mayo Clinic | N/A |
| Recruiting | EffecTAVI Registry NCT05235555 | Federico II University | — |
| Completed | CardioCel Tri-leaflet Repair Study NCT02629328 | Anteris Technologies Ltd. | N/A |
| Completed | Cardiac Remodeling and Circulating Biomarkers in Pediatric Left Ventricular Pressure Loading Lesions NCT02545790 | University of Colorado, Denver | — |
| Completed | Safety and Efficacy Study of Lotus Valve for Transcatheter Aortic Valve Replacement (REPRISE Japan) NCT02491255 | Boston Scientific Corporation | N/A |
| Completed | Aortic Valve Replacement Versus Conservative Treatment in Asymptomatic Severe Aortic Stenosis NCT02436655 | Clinical Centre of Serbia | N/A |
| Completed | Inflammation and Thrombosis in Patients With Severe Aortic Stenosis After Transcatheter Aortic Valve Replaceme NCT02486367 | University Hospitals Cleveland Medical Center | Phase 4 |
| Recruiting | High-Sensitivity Troponin T Plasma Levels in Patients With Aortic Stenosis (Tyrolean Aortic Stenosis Study-2) NCT02448485 | Medical University Innsbruck | — |
| Terminated | Sorin Universal REgistry on Aortic Valve Replacement NCT02679404 | Corcym S.r.l | — |
| Completed | Neuroprotection in Patients Undergoing Aortic Valve Replacement NCT02389894 | Icahn School of Medicine at Mount Sinai | N/A |
| Unknown | Radiation-Free Heart Catheterization Using MRI NCT02739087 | Joshua Kanter | N/A |
| Terminated | Mitroflow DL Post Approval Study- North America NCT02351726 | LivaNova | N/A |
| Completed | Feasibility And Safety of Early Discharge After Transfemoral Transcatheter Aortic Valve Implantation NCT02404467 | Institut für Pharmakologie und Präventive Medizin | — |
| Completed | PARTNER II Trial: S3iCAP NCT02687035 | Edwards Lifesciences | N/A |
| Completed | ACURATE Neo™ Aortic Bioprosthesis for Implantation Using the ACURATE TA™ LP Transapical Delivery System in Pat NCT02986737 | Symetis SA | N/A |
| Completed | REPRISE Next Generation Delivery System NCT02329496 | Boston Scientific Corporation | N/A |
| Active Not Recruiting | Left Atrial Appendage CLOSURE for the Prevention of Thromboembolisms in Patients Undergoing Aortic Bioprosthes NCT02321137 | University of Turku | N/A |
| Terminated | Safety and Efficacy Study of Lotus Valve for Transcatheter Aortic Valve Replacement NCT02202434 | Boston Scientific Corporation | N/A |
| Completed | Symetis ACURATE Neo™ Valve Implantation SAVI TF Registry NCT02306226 | Symetis SA | — |
| Completed | Medtronic CoreValve Evolut R U.S. Clinical Study NCT02207569 | Medtronic Cardiovascular | N/A |
| Completed | SOURCE 3: Observational Study to Evaluate Safety and Performance of SAPIEN 3 THV System in Real Life Practice NCT02698956 | Edwards Lifesciences | — |
| Active Not Recruiting | PERIGON Pivotal Trial NCT02088554 | Medtronic Cardiac Surgery | N/A |
| Completed | Study of Platelet Activation by Severe Aortic Stenosis and Its Correction by Transcatheter Aortic Valve Implan NCT02504632 | University Hospital, Toulouse | N/A |
| Unknown | Prevalence and Significance of Mutations in Genes Encoding NaPi-co-transporters in the Development of CAVD NCT02516800 | University of Aarhus | — |
| Completed | Pilot Study of Cognitive and Functional Outcomes Following TAVI NCT02089945 | Sunnybrook Health Sciences Centre | — |
| Completed | Aortic Valve and Root Measurements Under Real-Time 3-Dimensional Visualization During Angiography NCT02073617 | NYU Langone Health | N/A |
| Completed | Low-dose-contrast Cardiac Computed Tomography NCT02146768 | Baylor Research Institute | — |
| Completed | Performance and Safety of the Lotus™ Valve With a FLEXible Delivery System NCT03043404 | Boston Scientific Corporation | N/A |
| Completed | Non-contrast 3-dimensional Cardiac Magnetic Resonance Imaging NCT04496297 | Baylor Research Institute | — |
| Terminated | The CardioPAT Project: A Randomized Trial NCT02058134 | Rigshospitalet, Denmark | N/A |
| Suspended | Clinical Outcome of Patients With Low-gradient Severe Aortic Stenosis NCT02010177 | Sheba Medical Center | — |
| Completed | ACURATE TA™ Valve Implantation Registry: SAVI 2 NCT02663375 | Symetis SA | — |
| Recruiting | Functional and Quality of Life Improvement Following Transcatheter Heart Valve Implantation NCT02023060 | Sheba Medical Center | — |
| Completed | The Medtronic CoreValve™ Evolut R™ CE Mark Clinical Study NCT01876420 | Medtronic Cardiovascular | N/A |
| Completed | Assessment of Myocardial Tissue Damage in Aortic Stenosis NCT02101619 | Mayo Clinic | — |
| Completed | Prospective Balloon Aortic Valvuloplasty NCT02122900 | Baylor Research Institute | — |
| Completed | Cardiac MRI for Severe Aortic Stenosis NCT01638156 | American College of Radiology | — |
| Completed | Myocardial Efficiency of the Left Ventricle in Asymptomatic Patients With Aortic Valve Stenosis - a Prognostic NCT02076711 | Aarhus University Hospital | Phase 2 |
| Completed | Examination of Valve Insufficiency Before and After MitraClip or TAVI Procedure by 3D Echocardiography Compare NCT01966146 | RWTH Aachen University | N/A |
| Completed | Angiogenesis and Fibrosis in Aortic Stenosis NCT01837160 | University of Edinburgh | — |
| Completed | ROUTE Registry Of the Utilisation of the Transaortic (Tao) TAVI Approach Using the Edwards Sapien XT Valve NCT01991431 | Institut für Pharmakologie und Präventive Medizin | — |
| Completed | Transcatheter Aortic Valve Implantation Without Predilation NCT01539746 | University Hospital, Bonn | N/A |
| Withdrawn | A Comparison of Advanced Imaging Techniques in Aortic Stenosis NCT01775215 | Royal Brompton & Harefield NHS Foundation Trust | — |
| Active Not Recruiting | ProspeCtive, nOn-randoMized, MulticENter Clinical Evaluation of Edwards Pericardial Bioprostheses With a New T NCT01757665 | Edwards Lifesciences | N/A |
| Completed | Effect of Steroids on Cerebral Inflammation and Neuronal Damage After Surgical Aortic Valve Replacement NCT01755338 | Sahlgrenska University Hospital | N/A |
| Terminated | Aortic Stenosis and PhosphodiEsterase Type 5 iNhibition (ASPEN): A Pilot Study NCT01275339 | Washington University School of Medicine | Phase 4 |
| Completed | EDWARDS INTUITY Valve System CADENCE Study NCT02688153 | Edwards Lifesciences | N/A |
| Completed | Regression of Myocardial Fibrosis After Aortic Valve Replacement NCT02174471 | University College, London | — |
| Completed | Fetal Intervention for Aortic Stenosis and Evolving Hypoplastic Left Heart Syndrome NCT01736956 | University of California, San Francisco | N/A |
| Completed | ADVANCE Direct Aortic Study NCT01676727 | Medtronic Cardiac Rhythm and Heart Failure | — |
| Withdrawn | Neuropsychological Testing in Patients Undergoing Transvascular Aortic Valve Implantation NCT01648309 | Hadassah Medical Organization | — |
| Unknown | Von Willebrand Factor As a Biological Sensor of Blood Flow in Percutaneous Cardiac Procedure NCT02628509 | University Hospital, Lille | — |
| Terminated | Effect of Bisoprolol on Progression of Aortic Stenosis NCT01579058 | Asan Medical Center | Phase 4 |
| Unknown | Identification of Parameters in rapId-proGression Subgroup Patients With Moderate Aortic Stenosis NCT01575249 | Carol Davila University of Medicine and Pharmacy | — |
| Completed | EDWARDS INTUITY Valve System FOUNDATION Study NCT02338154 | Edwards Lifesciences | — |
| Completed | PARTNER II Trial: Placement of AoRTic TraNscathetER Valves II - Nested Registry 3/Valve-in-Valve NCT03225001 | Edwards Lifesciences | N/A |
| Completed | Erythropoietin + Iron Therapy for Anemic Patients Undergoing Aortic Valve Replacement NCT02390102 | Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec | Phase 3 |
| Completed | JUPITER Study: Transapical Aortic Valve Implantation for Aortic Regurgitation NCT01598844 | JenaValve Technology, Inc. | — |
| Completed | Correlation of Auscultatory Severity of Aortic Stenosis With Trans Thoracic Echocardiography NCT01605669 | United States Naval Medical Center, San Diego | — |
| Completed | EDWARDS INTUITY Valve System CADENCE-MIS Study NCT02672553 | Edwards Lifesciences | N/A |
| Completed | Microvascular Dysfunction in Aortic Stenosis NCT01658345 | University Hospitals, Leicester | — |
| Completed | DEFLECT I: Keystone Heart Embolic Deflection Trial NCT01448421 | Keystone Heart | N/A |
| Completed | A Comparison of Transcatheter Heart Valves in High Risk Patients With Severe Aortic Stenosis: The CHOICE Trial NCT01645202 | Segeberger Kliniken GmbH | N/A |
| Completed | Interest of Cardiac Computed Tomography to Optimize and Improve the Procedure of TAVI NCT01672268 | University Hospital, Grenoble | Phase 3 |
| Completed | The Role of Myocardial Fibrosis in Patients With Aortic Stenosis NCT01755936 | University of Edinburgh | — |
| Completed | Frailty Assessment Before Cardiac Surgery & Transcatheter Interventions NCT01845207 | Jewish General Hospital | — |
| Completed | Transcatheter Aortic Valve Implantation in Western NORway NCT04417829 | Haukeland University Hospital | — |
| Completed | Transcatheter Heart Valve (THV) Sizing and Leakage After Transcatheter Aortic Valve Implantation (TAVI) Before NCT02005640 | Aarhus University Hospital Skejby | — |
| Completed | Remifentanil/Sufentanil for CABG+/-AVR Evaluated by Recovery, Cognitive Function, Haemodynamics and Biochemica NCT02053818 | Aarhus University Hospital | Phase 4 |
| Unknown | Endothelial Progenitors in Aortic Stenosis: Association With Aortic Stenosis Progression and Severity NCT02060071 | Kaplan Medical Center | Phase 4 |
| Completed | TAVI Protocol - Paravertebral Block Study NCT01404975 | University Health Network, Toronto | N/A |
| Completed | Polymorphisms in the Vitamin D System and Health NCT01395303 | University of Tromso | — |
| Completed | The Role of Occult Cardiac Amyloid in the Elderly With Aortic Stenosis. NCT03029026 | Queen Mary University of London | — |
| Terminated | Aortic Stenosis and PhosphodiEsterase iNhibition With Aortic Valve Replacement (ASPEN-AVR): A Pilot Study NCT01272388 | Washington University School of Medicine | Phase 4 |
| Completed | Freedom SOLO Stentless Heart Valve Study NCT01115907 | Sorin Group USA, Inc. | Phase 3 |
| Completed | Microembolic Signals and Cerebrospinal Fluid Markers of Neuronal Damage After Surgical Aortic Valve Replacemen NCT01319799 | Sahlgrenska University Hospital | — |
| Completed | The Effect of the Hyperinsulinemic Normoglycemic Clamp on Myocardial Function and Utilization of Glucose NCT01187329 | The Cleveland Clinic | N/A |
| Completed | Role of Active Valvular Calcification and Inflammation in Patients With Aortic Stenosis NCT01358513 | University of Edinburgh | — |
| Completed | Early Surgery Versus Conventional Treatment in Very Severe Aortic Stenosis NCT01161732 | Asan Medical Center | N/A |
| Completed | Biomarkers in Aortic Stenosis - B.A.S.S. NCT01334801 | Mayo Clinic | — |
| Completed | The Plasma Serotonin and Aortic Stenosis: a Pilot Study. NCT02833090 | University Hospital, Toulouse | N/A |
| Unknown | Severe Aortic Stenosis in Patients Referred for Valve Surgery NCT01794832 | Oslo University Hospital | — |
| Completed | Frailty and Mortality in Older Old With Severe Aortic Stenosis NCT02745314 | Hospital de Meixoeiro | — |
| Completed | Acute Hemodynamic Effects of Sildenafil in Patients With Severe Aortic Stenosis NCT01060020 | Washington University School of Medicine | Phase 4 |
| Completed | Risk Prediction in Aortic Stenosis NCT01422044 | Thebiosignals.com | — |
| Unknown | Value of Oral Phytate (InsP6) in the Prevention of Progression of the Cardiovascular Calcifications NCT01000233 | Hospital Universitari Son Dureta | Phase 2 / Phase 3 |
| Completed | Microembolic Signals and Serum Markers of Neuronal Damage During Transcatheter Aortic Valve Implantation. NCT01237743 | Sahlgrenska University Hospital | — |
| Unknown | Water- and Salt-homeostasis in Healthy Humans, and in Patients With Heart- or Lung Disease NCT00830726 | Kolding Sygehus | — |
| Completed | Genetics of Aortic Stenosis: From Family Forms to the Common Forms NCT02890407 | Nantes University Hospital | — |
| Completed | The Effect of Glucose-Insulin-Potassium Infusion in Patients Undergoing Cardiac Surgery NCT00788242 | Christoph Ellenberger | N/A |
| Completed | Acquired Von Willebrand Syndrome in Severe Aortic Stenosis NCT00805051 | University Hospital, Basel, Switzerland | — |
| Withdrawn | Ventricular Remodeling In Patients With Aortic Stenosis Assessed Echocardiography NCT00774657 | Lahey Clinic | — |
| Terminated | Utility of Exercise-induced N-terminal (NT) Pro-brain Natriuretic Peptide Levels in Predicting Prognosis in As NCT00567437 | Duke University | N/A |
| Terminated | Speckle Tracking Imaging in Patients With Low Ejection Fraction Aortic Stenosis (SPArKLE-AS) NCT00535899 | The Cleveland Clinic | — |
| Active Not Recruiting | Genomic Investigation of Cardiovascular Diseases NCT00722748 | Scripps Translational Science Institute | — |
| Completed | The Effects of High Spinal Anesthesia on Heart Function, Stress Response and Pain Control in Aortic Valve Surg NCT00348920 | University of Manitoba | N/A |
| Suspended | TAVI and Gender Outcomes Aortic Stenosis Undergoing Transfemoral Transcatheter Aortic Valve Implantation. NCT04915976 | Imperial College Healthcare NHS Trust | — |
| Completed | Comparison of Blood and Crystalloid Cardioplegia NCT01941420 | Oslo University Hospital | — |
| Unknown | Aortic Stenosis in Elderly : Determinant of Progression NCT00338676 | Assistance Publique - Hôpitaux de Paris | — |