NCT03268135

Heart Failure and Aortic Stenosis Transcriptome

Study of the Transcriptomic Alterations in Heart Failure and Aortic Stenosis

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 500 (estimated)
• Sponsor: IRCCS Policlinico S. Donato · Academic / Other
• Sex: All
• Age: 40 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

This study is aimed to investigate the global transcriptome in order to determine the expression profile of messenger RNAs (mRNAs), as well as long noncoding- (lncRNAs) and micro noncoding-RNAs (miRNAs) in heart failure (HF) and in aortic stenosis (AS). The aim is to clarify their role in cardiac disease pathogenesis, as well as their potential as biomarkers. To this purpose, both tissue and blood specimens will be collected and patients will be compared to individuals not affected by cardiovascular diseases.

Detailed description

The investigators will collect plasma and cardiac tissue specimens from consenting subjects. The investigators will evaluate the expression of mRNAs, miRNAs and lncRNAs in patients affected by both end-stage and not end-stage HF as well as in patients affected by aortic stenosis and undergoing valve replacement and requiring cardiac myectomy. The tissue dysregulated RNAs will be next measured in plasma samples in order to clarify their potential as biomarkers.

Conditions

• Heart Failure
• Aortic Stenosis

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	measurement of RNAs

Timeline

• Start date: 2016-05-30
• Primary completion: 2024-12-31
• Completion: 2027-12-31
• First posted: 2017-08-31
• Last updated: 2025-04-30

Locations

2 sites across 1 country: Italy