NCT03310671

Aortic Stenosis in Subjects With Heterozygous Familial Hypercholesterolemia on Prolonged Treatment With Statins

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 900 (estimated)
• Sponsor: Instituto Aragones de Ciencias de la Salud · Other Government
• Sex: All
• Age: 55 Years
• Healthy volunteers: Accepted

Summary

Aortic stenosis (AE) is a disease that has been increasing steadily in recent years in most countries, including Spain.Risk factors for the development of AE include age, hypercholesterolemia, diabetes mellitus and arterial hypertension, the classic risk factors for the development of atherosclerosis. However, lipid-lowering therapy with statins and ezetimibe has not been shown to reduce the risk of long-term progression of AE by unknown mechanisms. All this suggests that subjects with HFhe have a high risk of developing AD, which has not been shown by the high coronary mortality in this population that precedes aortic calcification

Detailed description

The study includes a single clinical visit with collection of clinical data, blood extraction and the performance of a transthoracic echocardiogram. This visit may be made on different days, but always within 30 days of signing the informed consent.

Conditions

• Aortic Stenosis
• Arteriosclerosis
• Familial Hypercholesterolemia
• Conventional Transthoracic Echocardiogram

Interventions

Type	Name	Description
PROCEDURE	Echocardiogram	Conventional transthoracic echocardiogram by an echocardiographer trained to perform and centered on aortic valve Pick up from: * Mean transvalvular pressure gradient * Aortic valve * Aortic valve opening area * Aortic valve opening area adjusted for body mass index * Bicuspid or tricuspid aorta * Thickness of the upper valve\> 3 mm

Timeline

• Start date: 2017-07-18
• Primary completion: 2018-07-18
• Completion: 2018-07-18
• First posted: 2017-10-16
• Last updated: 2017-10-16

Locations

1 site across 1 country: Spain