| Recruiting | The ORIGIN-FH Study NCT07470723 | University of Wisconsin, Madison | N/A |
| Recruiting | National Network for Cardiovascular Genomics: Advancing Cardiovascular Healthcare for Hereditary Diseases in B NCT06546137 | Hospital do Coracao | — |
| Recruiting | Child-Parent Familial Hypercholesterolemia Screening NCT04529967 | Children's Hospital of Fudan University | — |
| Recruiting | An Adapted Brazilian Cardioprotective Diet, Phytosterols and Krill Oil in Familial Hypercholesterolemia (DICA- NCT06331195 | Hospital do Coracao | N/A |
| Recruiting | Atlantic Lipid Lowering Treatment Optimization Program NCT06439654 | Atlantic Health System | N/A |
| Not Yet Recruiting | Safety and Efficacy Study of NGGT006 in Refractory Hypercholesterolemia Patients NCT06293729 | Suzhou Municipal Hospital | EARLY_Phase 1 |
| Recruiting | Clinical Exploration Trial of YOLT-101 in the Treatment of Familial Hypercholesterolemia (FH) NCT06458010 | RenJi Hospital | EARLY_Phase 1 |
| Recruiting | Clinical Exploration Trial of YOLT-101 in the Treatment of Familial Hypercholesterolemia (FH) NCT06461702 | The First Affiliated Hospital of Bengbu Medical University | EARLY_Phase 1 |
| Completed | Unravelling the Impact of Diet on Cardiovascular Health in Treated Heterozygous Familial Hypercholesterolemia. NCT06389825 | Laval University | N/A |
| Completed | Study of Obicetrapib & Ezetimibe Fixed Dose Combination on Top of Maximum Tolerated Lipid-Modifying Therapies NCT06005597 | NewAmsterdam Pharma | Phase 3 |
| Recruiting | 2-Hydroxybenzylamine (2-HOBA) to Reduce HDL Modification and Improve HDL Function in Familial Hypercholesterol NCT04941599 | Vanderbilt University Medical Center | Phase 2 |
| Recruiting | Familial Hypercholesterolemia Interpretive Comment - Nudging to Detection. NCT05614219 | Odense University Hospital | N/A |
| Active Not Recruiting | The Danish Familial Hypercholesterolemia Organized Coronary Screening Trial NCT05758779 | Odense University Hospital | N/A |
| Completed | A Study of Enlicitide Decanoate (MK-0616 Oral PCSK9 Inhibitor) in Adults With Hypercholesterolemia (MK-0616-01 NCT05952856 | Merck Sharp & Dohme LLC | Phase 3 |
| Completed | A Study of Enlicitide Decanoate (MK-0616 Oral PCSK9 Inhibitor) in Adults With Heterozygous Familial Hyperchole NCT05952869 | Merck Sharp & Dohme LLC | Phase 3 |
| Completed | A VSA003 Phase 1 Study in Chinese Adult Healthy Volunteers NCT05851066 | Visirna Therapeutics HK Limited | Phase 1 |
| Completed | Brazilian Cardioprotective Diet, Phytosterols and Krill Oil in Patients With Familial Hypercholesterolemia NCT05695937 | Hospital do Coracao | N/A |
| Recruiting | Comparing Direct vs Indirect Methods for Cascade Screening NCT05348564 | University of Maryland, Baltimore | N/A |
| Not Yet Recruiting | EPIRUS FH Reverse Cascade Screening NCT05825612 | Hellenic Atherosclerosis Society | — |
| Enrolling By Invitation | Penn Family Screening for Familial Hypercholesterolemia NCT05750667 | Northwestern University | N/A |
| Completed | Patterns of Inclisiran Use in the Real World: An Analysis of US Databases NCT07023445 | Novartis Pharmaceuticals | — |
| Enrolling By Invitation | Collaborative Approach to Reach Everyone With Familial Hypercholesterolemia (CARE-FH) NCT05284513 | Geisinger Clinic | N/A |
| Completed | Evaluate the Effect of Obicetrapib in Patients With HeFH on Top of Maximum Tolerated Lipid-Modifying Therapies NCT05425745 | NewAmsterdam Pharma | Phase 3 |
| Completed | Equitable Implementation of Cascade Screening for Familial Hypercholesterolemia NCT05430191 | Northwestern University | — |
| Active Not Recruiting | Effect of Breastfeeding on Lipid Profile and Cardiovascular Risk Markers in Women With Familial Hypercholester NCT05367310 | Oslo University Hospital | — |
| Completed | A Study of the Efficacy and Safety of Enclitide Chloride (MK-0616 Oral PCSK9 Inhibitor) in Adults With Hyperch NCT05261126 | Merck Sharp & Dohme LLC | Phase 2 |
| Completed | Coronary and Heart Effects of Early Treatment in Familial Hypercholesterolemia NCT05352386 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | N/A |
| Enrolling By Invitation | Improving Diagnosis and Clinical Management of Familial Hypercholesterolemia Through Integrated Machine Learni NCT05746247 | University of Pennsylvania | N/A |
| Active Not Recruiting | Improved Diagnosis of Familial Hypercholesterolemia Across the Northland (ID-FH) NCT05238519 | Essentia Health | Phase 3 |
| Completed | Unravelling the Impact of Diet on Cardiovascular Health in Heterozygous Familial Hypercholesterolemia. NCT05181553 | Laval University | N/A |
| Unknown | Advancing Cardiac Care Unit-based Rapid Assessment and Treatment of hypErcholesterolemia NCT05218005 | University of British Columbia | N/A |
| Completed | Randomized Study to Evaluate the Effect of Obicetrapib on Top of Maximum Tolerated Lipid-Modifying Therapies NCT05142722 | NewAmsterdam Pharma | Phase 3 |
| Not Yet Recruiting | Exosome-based Nanoplatform for Ldlr mRNA Delivery in FH NCT05043181 | Tang-Du Hospital | Phase 1 |
| Unknown | Advanced Lipoproptein Profiling and Cardiovascular Risk Stratification in Familial Hypercholesterolemia NCT05066932 | Assistance Publique - Hôpitaux de Paris | — |
| Unknown | A Prospective Cohort Study on Familial Hypercholesterolemia in Health Examination Population NCT04958629 | Peking University Third Hospital | — |
| Unknown | Pilot Study for a National Screening for Familial Hypercholesterolemia NCT05271305 | Centre Hospitalier du Luxembourg | — |
| Enrolling By Invitation | Evaluation of a Digiphysical Screening Method to Identify and Diagnose Familial Hypercholesterolemia NCT04929457 | Karolinska Institutet | — |
| Completed | The Use of Mobile Health Technology and Behavioral Economics to Encourage Adherence in Adolescents NCT04458766 | Boston Children's Hospital | N/A |
| Enrolling By Invitation | Long-term Efficacy and Safety of OLE LIB003 in HoFH, HeFH, and High-risk CVD Patients Requiring Further LDL-C NCT04798430 | LIB Therapeutics LLC | Phase 3 |
| Completed | Pediatric Reporting of Adult-Onset Genomic Results NCT03832985 | Geisinger Clinic | EARLY_Phase 1 |
| Completed | Cascade Genetic Testing of Familial Hypercholesterolemia NCT04419090 | Center for Primary Care and Public Health (Unisante), University of Lausanne, Switzerland | N/A |
| Unknown | Familial Hypercolerstremia as Risk Factor in Stemi Patient Who Underwent Ppci NCT03900169 | Assiut University | — |
| Unknown | A Study to Determine the Safety, Tolerability, and Efficacy of SHR-1209 in Patients With Familial Hypercholest NCT04455581 | Jiangsu HengRui Medicine Co., Ltd. | Phase 2 |
| Active Not Recruiting | Genetic Testing and Motivational Counseling for FH NCT04656028 | National Medical Research Center for Therapy and Preventive Medicine | N/A |
| Active Not Recruiting | Genetic Causes of Familial Hypercholesterolemia NCT04101149 | Region Örebro County | — |
| Completed | Study of ARO-ANG3 in Healthy Volunteers and in Dyslipidemic Patients NCT03747224 | Arrowhead Pharmaceuticals | Phase 1 |
| Completed | Universal Familial Hypercholesterolemia Screening in Children NCT04507984 | University of Ljubljana, Faculty of Medicine | — |
| Terminated | Impact of LDL-cholesterol Lowering on Platelet Activation NCT03331666 | Columbia University | Phase 4 |
| Completed | Alirocumab and Plaque Burden In Familial Hypercholesterolaemia NCT05465278 | Fundación Hipercolesterolemia Familiar | Phase 4 |
| Unknown | a Prospective Pilot Study of Screening Out Rate and Clinical Management of Familial Hypercholesterolemia NCT03398954 | China Cardiovascular Association | — |
| Recruiting | PMMHRI - Familial Hypercholesterolemia Registry NCT06571630 | Polish Mother Memorial Hospital Research Institute | — |
| Completed | IN-TANDEM Familial Hypercholesterolemia Pilot Study NCT03253432 | University of Pennsylvania | — |
| Unknown | Aortic Stenosis in Subjects With Heterozygous Familial Hypercholesterolemia on Prolonged Treatment With Statin NCT03310671 | Instituto Aragones de Ciencias de la Salud | — |
| Unknown | Improving Identification of Familial Hypercholesterolaemia in Primary Care (FAMCAT) NCT03934320 | University of Nottingham | N/A |
| Withdrawn | Cross-over Pilot Study of Blood Cholesterol Response to Dietary Saturated Fat in Patients With Autosomal Domin NCT03756779 | University of Texas Southwestern Medical Center | N/A |
| Completed | An Extension Trial of Inclisiran in Participants With Cardiovascular Disease and High Cholesterol NCT03060577 | Novartis Pharmaceuticals | Phase 2 |
| Completed | Familial Hypercholesterolemia in Turkey (A-HIT2) NCT03110250 | Ege University | — |
| Unknown | Genetic Causes of Hypercholesterolaemia in the Emirati Population NCT03597958 | Imperial College London Diabetes Centre | — |
| Unknown | Greek Registry - Familial Hypercholesterolaemia NCT03140605 | Hellenic College of Treatment of Atherosclerosis | — |
| Completed | Treatment Rates and Compliance to Treatment in Patients With Familial Hypercholesterolemia NCT04494464 | Ankara Yildirim Beyazıt University | — |
| Completed | Safety, Tolerability and Efficacy of Evolocumab (AMG 145) in Children With Inherited Elevated Low-density Lipo NCT02624869 | Amgen | Phase 3 |
| Completed | Pediatric Population Screening for Type 1 Diabetes and Familial Hypercholesterolemia in Lower Saxony, Germany NCT02750527 | Kinderkrankenhaus auf der Bult | — |
| Unknown | Familial Hypercholesterolemia Amongst Patients With Acute Coronary Syndrome NCT02870660 | Isfahan University of Medical Sciences | — |
| Unknown | Developing and Implementing Familial Hypercholesterolemia Registry NCT02865694 | Isfahan University of Medical Sciences | — |
| Completed | Long Term Post Marketing Specified Drug Use Result Survey for Evolocumab in Japan NCT02808403 | Amgen | — |
| Completed | A Clinical Trial to Assess the Long Term Safety and Tolerability of MK-0653H in Japanese Participants With Hyp NCT02748057 | Organon and Co | Phase 3 |
| Completed | Postprandial Response After Intake of Meals With Different Fatty Acid Composition NCT02729857 | University of Oslo | N/A |
| Completed | Return of Actionable Variants Empirical Study NCT03640234 | Mayo Clinic | — |
| Completed | Trial to Evaluate the Effect of ALN-PCSSC Treatment on Low Density Lipoprotein Cholesterol (LDL-C) NCT02597127 | The Medicines Company | Phase 2 |
| Completed | Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of IONIS ANGPTL3-LRx in Healthy Volunteers With E NCT02709850 | Ionis Pharmaceuticals, Inc. | Phase 1 |
| Completed | Effects of LDL Apheresis System on the Expression of Genes Involved in Lipoprotein Metabolism and Inflammation NCT02462655 | Laval University | N/A |
| Recruiting | Lipid Transport Disorder Italian Genetic Record (LIPIGEN) NCT06362473 | Fondazione SISA (Societa Italiana per lo Studio della Arteriosclerosi) | — |
| Unknown | A Registration Study for Familial Hypercholesterolemia in Taiwan NCT03152656 | National Taiwan University Hospital | — |
| Recruiting | EAS Familial Hypercholesterolaemia Studies Collaboration NCT04272697 | Imperial College London | — |
| Terminated | French Observatory of Familial Hypercholesterolemia in Cardiology NCT02013713 | French Cardiology Society | — |
| Unknown | Atherosclerosis in Familial Hypercholesterolemia NCT02489253 | University College, London | — |
| Completed | Relationships Between Plasma PCSK9 Levels, LDL-cholesterol Concentrations and Lipoprotein (a) Levels in Famili NCT02225340 | Laval University | — |
| Recruiting | Russian Familial Hypercholesterolemia Registry NCT02208869 | Russian Cardiology Research and Production Center | — |
| Recruiting | Familial Hypercholesterolemia Canada / Hypercholesterolemie Familiale Canada NCT02009345 | McGill University Health Centre/Research Institute of the McGill University Health Centre | — |
| Recruiting | Early Detection of Familial Hypercholesterolemia in Children NCT04370899 | Institut Investigacio Sanitaria Pere Virgili | — |
| Completed | Effect of Omega-3 Fatty Acid on Endothelial Function NCT01813006 | Nordlandssykehuset HF | Phase 3 |
| Unknown | Cardiovascular Disease in FH Heterozygous NCT01783405 | Sociedad Española de Arteriosclerosis | — |
| Completed | Efficacy of a New Symbiotic Formulation in Children With Familial Hypercholesterolemia NCT02048410 | Federico II University | Phase 1 / Phase 2 |
| Completed | Effects of Low-density Lipoprotein (LDL) Apheresis on Inflammatory and Lipid Markers NCT01138371 | Emory University | — |
| Completed | Amlodipine/Atorvastatin (Caduet®) Drug Use Investigation (Regulatory Post Marketing Commitment Plan) NCT01107743 | Pfizer's Upjohn has merged with Mylan to form Viatris Inc. | — |
| Completed | Long Term, Follow-on Study of Lomitapide in Patients With Homozygous Familial Hypercholesterolemia NCT00943306 | Aegerion Pharmaceuticals, Inc. | Phase 3 |
| Unknown | Soy Food Intervention Trial NCT00924339 | Medical University of Vienna | N/A |
| Completed | Atorvastatin Three Year Pediatric Study NCT00827606 | Pfizer's Upjohn has merged with Mylan to form Viatris Inc. | Phase 3 |
| Unknown | Effect of Rapeseed Oil and Sunflower Oil NCT00924274 | Medical University of Vienna | N/A |
| Completed | A Study of the Safety and Efficacy of Patients With Familial Hypercholesterolaemia Taking Colesevelam as add-o NCT00655265 | Genzyme, a Sanofi Company | Phase 4 |
| Completed | A 52-week Post-marketing, Observational Study to Confirm the Safety and Efficacy of Zetia Alone or in Combinat NCT00705211 | Organon and Co | — |
| Completed | A 12-week Post-marketing, Observational Study to Confirm the Safety and Efficacy of Zetia Alone or in Combinat NCT00704444 | Organon and Co | — |
| Withdrawn | Effect of APL180 on Endothelial Function in Familial Hypercholesterolemia Patients NCT00751608 | Novartis Pharmaceuticals | Phase 2 |
| Completed | PLUTO: Pediatric Lipid-redUction Trial of rOsuvastatin NCT00355615 | AstraZeneca | Phase 3 |
| Terminated | Implitapide in Patients With Heterozygous Familial Hypercholesterolemia (HeFH) on Maximal Concurrent Lipid-Low NCT00079859 | Medical Research Laboratories International | Phase 2 |
| Terminated | Implitapide in Patients With Homozygous Familial Hypercholesterolemia (HoFH) on Maximal Concurrent Lipid-Lower NCT00079846 | Medical Research Laboratories International | Phase 2 |
| Completed | Detection of Familial Hypercholesterolaemia in Cardiovascular Disease Registry NCT02778646 | University College, London | — |
| Completed | Ezetimibe (SCH 58235) Taken With Either Atorvastatin or Simvastatin in Participants With Familial Hypercholest NCT03884452 | Organon and Co | Phase 3 |
| Completed | Low-Density Lipoprotein (LDL) Apheresis Using H.E.L.P. Therapy NCT00916643 | B. Braun Medical Inc. | Phase 4 |
| Completed | Phase I Study of Ex Vivo Liver-Directed Gene Therapy for Familial Hypercholesterolemia NCT00004809 | National Center for Research Resources (NCRR) | Phase 1 |