NCT03253432

IN-TANDEM Familial Hypercholesterolemia Pilot Study

INTegrating Active Case-finding With Next-generation Sequencing for Diagnosis Through Electronic Medical Records (IN-TANDEM): Familial Hypercholesterolemia Pilot Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 378 (actual)
• Sponsor: University of Pennsylvania · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to validate the use of the FH Foundation FIND FH® Algorithm as a clinical decision support tool. FIND FH (Flag/Identify/Network/Engage) is a national initiative that utilizes machine learning and data mining techniques to identify individuals whose profiles are consistent with FH patients. The algorithm will be tested in adults with at least one cardiovascular comorbidity. Study subjects will be asked to provide either a saliva, buccal or venous blood sample for DNA and biomarker analysis

Conditions

• Familial Hypercholesterolemia

Interventions

Type	Name	Description
OTHER	Genetic testing	Targeted next-generation sequencing for familial hypercholesterolemia causative mutations

Timeline

• Start date: 2017-07-20
• Primary completion: 2018-11-07
• Completion: 2018-11-07
• First posted: 2017-08-17
• Last updated: 2019-02-28

Locations

2 sites across 1 country: United States