NCT06595407

Loss of Y Chromosome in Aortic Stenosis

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 200 (estimated)
• Sponsor: University of Virginia · Academic / Other
• Sex: Male
• Age: 40 Years
• Healthy volunteers: Accepted

Summary

The most common heart valve disease in humans is aortic stenosis which is a critical narrowing of the valve through which the heart has to pump blood to the rest of the body. This condition occurs in 2-3% of adults over 65 years of age and when it progresses to a severe stage leads to heart failure and need for valve replacement procedures (including surgery and catheter-based replacement). Aortic stenosis has a strong male predominance. The purpose of this study is to evaluate whether loss of Y-chromosome from circulating blood cells in males, which has been associated with TGF-beta-related fibrosis of other organs, is associated with the development of aortic stenosis.

Conditions

• Aortic Stenosis

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Blood analysis for loss-of-Y chromosome	Analysis for the percentage of circulating leukocytes with loss-of-y chromosome

Timeline

• Start date: 2024-08-15
• Primary completion: 2025-12-31
• Completion: 2026-06-01
• First posted: 2024-09-19
• Last updated: 2024-09-19

Locations

1 site across 1 country: United States